Abstract:
:More than 7 million stress perfusion studies are performed in the United States annually, 44% with pharmacological vasodilator stress agents. Both adenosine and dipyridamole are nonselective coronary vasodilators that are commonly used for stress perfusion imaging. These agents are safe and provide an effective means to diagnose coronary artery disease. A newer agent, regadenoson, is an adenosine receptor agonist that is selective for coronary vasodilation. Regadenoson is noninferior to adenosine for the detection of ischemia and is better tolerated by patients. Recent trials such as INSPIRE (Adenosine Sestamibi Post-Infarction Evaluation) and the COURAGE (Results from Clinical Outcomes Utilizing Revascularization and Aggressive Guideline-driven Drug Evaluation) Nuclear Imaging Substudy have established clearly that noninvasive risk stratification with vasodilator testing is an important and appropriate step in guiding medical therapy and invasive coronary intervention.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Druz RSdoi
10.1053/j.semnuclmed.2008.12.003subject
Has Abstractpub_date
2009-05-01 00:00:00pages
204-9issue
3eissn
0001-2998issn
1558-4623pii
S0001-2998(08)00139-6journal_volume
39pub_type
杂志文章,评审abstract::Suspecting and diagnosing venous thrombosis and pulmonary embolism remain major clinical problems. For a variety of reasons, including the patient's pre-existing cardiac and pulmonary status and the release of humoral mediators, pulmonary emboli evoke varied responses in different patients. Symptoms and signs of pulmo...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80131-x
更新日期:1991-10-01 00:00:00
abstract::Nuclear dacryocystography is simple, relatively harmless method of evaluating patients suspected of having abnormalities of the nasolacrimal drainage system. A group of normal saline containing approximately 100 muCi of 99mTc-pertechnetate is placed on the conjunctiva near the lateral canthus, and serial scintigrams a...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(81)80022-0
更新日期:1981-10-01 00:00:00
abstract::Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improv...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80176-x
更新日期:1990-01-01 00:00:00
abstract::Malignant endocrine disorders have been an enigma over the last few decades, from genetic, clinical, and imaging perspectives. The detection of the primary tumor and the identification of recurrent disease have been essentially based on various anatomic techniques, with localization procedures extensively developed fo...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/snuc.2001.23530
更新日期:2001-07-01 00:00:00
abstract::In order to assess the role of 99mTc-iminodiacetic acid (IDA) cholescintigraphy in evaluating postoperative patients, a total of 213 studies were performed in 189 patients over a 3-year time period. Of these, 130 studies were obtained in 125 cases with signs and/or symptoms suggesting postcholecystectomy syndrome. A n...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(82)80027-5
更新日期:1982-01-01 00:00:00
abstract::There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologica...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(76)80034-7
更新日期:1976-01-01 00:00:00
abstract::99mTc-PYP myocardial scintigrams represent a means to detect and localize acute myocardial necrosis. These scintigrams are expected to be abnormal with acute myocardial infarcts of at least 3 grams in weight if serial imaging is utilized and proper attention to technique is provided. Any etiology of myocardial necrosi...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(80)80029-8
更新日期:1980-01-01 00:00:00
abstract::Depending on the iodine supply of an area, the incidence of thyroid cancer ranges between 4 and 12/100,000 per year. To detect thyroid cancer in an early stage, the assessment of thyroid nodules includes ultrasonography, ultrasonography-guided fine-needle aspiration biopsy, and conventional scintigraphic methods using...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2006.03.002
更新日期:2006-07-01 00:00:00
abstract::Prospective delineation of viable from nonviable myocardium in patients with coronary artery disease in an important factor in deciding whether a patient should be revascularized or treated medically. Two common techniques--single-photon emission computed tomography (SPECT) and positron-emission computed tomography (P...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(96)80007-9
更新日期:1996-10-01 00:00:00
abstract::Vital blue dyes were used to show the feasibility and accuracy of intraoperative lymphatic mapping of the sentinel node (SN) in patients with melanoma, breast cancer, and other solid tumors. Surgeons who have successfully completed an adequate number of cases of intraoperative mapping and sentinel lymph node dissectio...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(00)80058-6
更新日期:2000-01-01 00:00:00
abstract::The advantage of immunoscintigraphy over autologous leukocyte techniques in the imaging of infection is the simplicity of its use compared with techniques that require the isolation of autologous white blood cells. The advantage over 99mTc- or 111In-labeled nonspecific human immunoglobulin is the excellent target-to-b...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(05)80228-4
更新日期:1994-04-01 00:00:00
abstract::Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in a...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2018.10.007
更新日期:2019-01-01 00:00:00
abstract::The convenience of (18)F-fluoride imaging is undeniable both because of its favorable tracer and because of its technical characteristics, including high image quality and short examination times leading to increased patient comfort. Depending on the activity administered, the radiation dose to patients is about compa...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2013.06.004
更新日期:2013-11-01 00:00:00
abstract::There seems little doubt that the ability to prepare antibodies with a unique specificity for surface tumor antigens will have a tremendous usefulness in the diagnostic and therapeutics of cancer. This usefulness will be wide-ranged when the antibodies are labeled with radioisotopes as tools for screening for primary ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(76)80015-3
更新日期:1976-10-01 00:00:00
abstract::The short range and high linear energy transfer of α-particles offer the potential for efficient tumor killing while sparing normal bystander cells. Hematologic malignancies are ideally suited to targeted α-particle therapy (TAT) due to easy accessibility of malignant cells in blood, bone marrow, lymph nodes, and sple...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2019.09.002
更新日期:2020-03-01 00:00:00
abstract::Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucos...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2011.02.003
更新日期:2011-07-01 00:00:00
abstract::Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgk...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2017.09.007
更新日期:2018-01-01 00:00:00
abstract::Radiolabeling of red cells and their clinical and research application in nuclear medicine constitute an area of continued interest and steady growth during the past two decades. Significant advances have been made so that at the present time, radiolabels with sufficient in vitro and in vivo stability are available fo...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(84)80022-7
更新日期:1984-04-01 00:00:00
abstract::Prostate cancer remains an important and growing health problem. Advances in imaging of prostate cancer may help to achieve earlier and more accurate diagnosis and treatment. We review the various strategies using reporter genes for molecular imaging of prostate cancer. These approaches are emerging as valuable tools ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2007.09.002
更新日期:2008-01-01 00:00:00
abstract::A comprehensive review of the effects of exposure to low levels of ionizing radiation, BEIR VII-Phase 2: Health Risks From Exposure to Low Levels of Ionizing Radiation, was published in 2006. The BEIR (Biological Effects of Ionizing Radiation) reports are a series of publications by the National Academy of Sciences. T...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2008.05.006
更新日期:2008-09-01 00:00:00
abstract::The process of discovering and developing a new pharmaceutical is a long, difficult, and risky process that requires numerous resources. Molecular imaging techniques such as PET have recently become a useful tool for making decisions along a drug candidate's development timeline. PET is a translational, noninvasive im...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2017.05.006
更新日期:2017-09-01 00:00:00
abstract::Consolidating personal computers (PCs) with nuclear medicine technology can create high computational power comparable with that produced by vendor-specific computer equipment, and at more affordable prices. The integration of a standard platform and operating system with a large installed base has enabled our departm...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80250-8
更新日期:1994-01-01 00:00:00
abstract::2-deoxy-2-[18F] fluoro-D-glucose (18FDG) was developed in 1976 in a collaboration between scientists at the National Institutes of Health, the University of Pennsylvania, and Brookhaven National Laboratory. It was developed for the specific purpose of mapping brain glucose metabolism in living humans, thereby serving ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/snuc.2002.29270
更新日期:2002-01-01 00:00:00
abstract::The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2016.10.006
更新日期:2017-03-01 00:00:00
abstract::In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients ar...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2016.01.003
更新日期:2016-07-01 00:00:00
abstract::The increasing use of automated blood chemistry screens for serum calcium levels along with improved methods in measuring parathyroid hormone (PTH) levels have made the diagnosis of parathyroid disease a common clinical problem. Parathyroid adenomas account for the majority of primary hyperparathyroidism with diffuse ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(85)80024-6
更新日期:1985-04-01 00:00:00
abstract::Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2015.10.005
更新日期:2016-03-01 00:00:00
abstract::Rhenium-186 (tin)hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in skeletal metastases in patients with advanced cancer. A single intravenous administration of approximately 34 mCi (1,258 MBq) resulted in significant improvement in pain in 33 of 43 evaluable patients (77%) following...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80155-2
更新日期:1992-01-01 00:00:00
abstract::Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2020.02.011
更新日期:2020-05-01 00:00:00
abstract::The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.03.008
更新日期:2014-05-01 00:00:00