Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III).

Abstract:

:In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.

journal_name

Semin Nucl Med

authors

Stein PD,Gottschalk A,Sostman HD,Chenevert TL,Fowler SE,Goodman LR,Hales CA,Hull RD,Kanal E,Leeper KV Jr,Nadich DP,Sak DJ,Tapson VF,Wakefield TW,Weg JG,Woodard PK

doi

10.1053/j.semnuclmed.2008.06.003

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

462-70

issue

6

eissn

0001-2998

issn

1558-4623

pii

S0001-2998(08)00080-9

journal_volume

38

pub_type

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