Abstract：
:Radiolabeling of red cells and their clinical and research application in nuclear medicine constitute an area of continued interest and steady growth during the past two decades. Significant advances have been made so that at the present time, radiolabels with sufficient in vitro and in vivo stability are available for diverse applications. Technetium-99m-labeled red cells in particular have revolutionized the field of cardiovascular nuclear medicine by making possible the external evaluation of various heart parameters with minimum radiation dose or trauma to the patient. Among other areas of study that use 99mTc -RBC are blood pool imaging, detection of vascular malformations, red cell mass determination, detection of gastrointestinal bleeding, and of hemangiomas. Heat-damaged 99mTc -RBC find application in spleen imaging, accessory spleen localization, detection of GI bleeding, and in other areas. A critical evaluation is presented of the various in vitro and in vivo labeling techniques that are currently available for red cell labeling. Even though the presently used procedures provide satisfactory labeled preparations, ideal radioisotopic RBC labels remain to be developed. Intermediate (2-3 days) as well as long-lived (approximately 30 days) radionuclidic labels are highly desirable for a number of clinical procedures where 99mTc is not useful due to its short half-life. A clearer understanding of the mechanistic aspects of various labeling reactions is expected to aid in the design of better and improved RBC labels that will help fulfill various areas of need in nuclear medicine applications. New approaches such as the use of radiolabeled antibodies to red cell antigens, or labeling specific receptor sites in the cell may lead to substantial improvements in the labeling methodology and could yield labeled cells with the least damage and maximum in vivo stability.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Srivastava SC,Chervu LRdoi
10.1016/s0001-2998(84)80022-7subject
Has Abstractpub_date
1984-04-01 00:00:00pages
68-82issue
2eissn
0001-2998issn
1558-4623pii
S0001-2998(84)80022-7journal_volume
14pub_type
杂志文章,评审abstract：:The high-level expression of somatostatin receptors (SSTR) on various tumor cells has provided the molecular basis for successful use of radiolabeled peptide analogues as tumor tracers in nuclear medicine. The vast majority of human tumors seem to overexpress one or the other of 5 distinct hSSTR subtype receptors. Whe...
journal_title：Seminars in nuclear medicine
pub_type： 临床试验,杂志文章,多中心研究
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abstract：:Heart transplantation is an effective and life-saving therapy for patients with end-stage heart disease. Cardiac allograft vasculopathy (CAV) is a frequent complication after heart transplantation and a leading cause of graft failure and death. The diffuse involvement of the coronary macro- and microvasculature in CAV...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2004.03.004
更新日期：2004-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(81)80027-x
更新日期：1981-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(82)80015-9
更新日期：1982-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(96)80007-9
更新日期：1996-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1053/snuc.2000.9544
更新日期：2000-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：1985-04-01 00:00:00
abstract：:In the early 1970s, when Seminars in Nuclear Medicine started publication, little was known about the quality of reporting in biomedical journals. Senior scholars were invited to become scientific editors of journals based on their research credibility and stature. Their knowledge of journalology (publication science)...
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pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：1994-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：1993-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
abstract：:In the 1980s, the (111)In-labeled somatostatin analog OctreoScan (Covidien, Hazelwood, MO) was developed for imaging of somatostatin receptor subtype 2 (sst(2)) overexpressing tumors. On the basis of this success, peptide receptor radionuclide therapy (PRRT) was developed using similar somatostatin analogs with differ...
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pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
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更新日期：2014-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2009-11-01 00:00:00
abstract：:Much efficacy is gained in clinical practice if a single agent can be used for both diagnosis and therapy, a practice termed theranostics. Metaiodobenzylguanidine (mIBG), a norepinephrine analogue with high sensitivity and specificity for neuroblastoma, is an exemplar of theranostics. The physiologic biodistribution o...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
abstract：:In spite of localization of gallium in the lungs in a large variety of inflammatory pulmonary diseases, the chest radiograph is and will continue to be the principal diagnostic tool for evaluation of pulmonary inflammatory disease. The 67Ga-citrate scan, however, serves as a study complementary to chest radiography be...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(80)80007-9
更新日期：1980-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(78)80036-1
更新日期：1978-04-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2008.12.003
更新日期：2009-05-01 00:00:00
