Abstract：
:(18)F-fluorodeoxyglucose (FDG) is the radiotracer used in the vast majority of positron emission tomography (PET) cancer studies. FDG is a powerful radiotracer that provides valuable data in many cancer types. Normal FDG biodistribution is easily identified. In the PET-only era, physiological uptake provided important anatomical landmarks. However, the normal biodistribution of FDG is often variable and can be altered by intrinsic or iatrogenic factors. Recognizing these patterns of altered biodistribution is important for optimal FDG-PET interpretation. Altered FDG uptake in muscles, brown adipose tissue, bone marrow, the urinary tract, and the bowel is demonstrated in a significant proportion of patients, which can hide underlying malignant foci or mimic malignant lesions. The introduction of PET/computed tomography revolutionized PET imaging, bringing much-needed anatomical information. This modality allowed better characterization of some types of uptake, particularly brown adipose tissue FDG uptake. Different approaches to minimize interference from altered FDG biodistribution should be considered when performing PET scans. Otherwise, careful review and correlation of metabolic (FDG-PET) and anatomical (computed tomography) data should be performed to accurately characterize the foci of increased FDG uptake.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Cohade Cdoi
10.1053/j.semnuclmed.2010.02.001subject
Has Abstractpub_date
2010-07-01 00:00:00pages
283-93issue
4eissn
0001-2998issn
1558-4623pii
S0001-2998(10)00004-8journal_volume
40pub_type
杂志文章,评审abstract：:In spite of localization of gallium in the lungs in a large variety of inflammatory pulmonary diseases, the chest radiograph is and will continue to be the principal diagnostic tool for evaluation of pulmonary inflammatory disease. The 67Ga-citrate scan, however, serves as a study complementary to chest radiography be...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(80)80007-9
更新日期：1980-07-01 00:00:00
abstract：:Mammographic screening of women age 40 and older can reduce breast cancer deaths by at least 30% to 40%. However, not all cancers are detected by mammography. Although a new supplementary modality for screening could, in theory, fill in this detection gap, such utilization must be based on rigorous demonstration of it...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(99)80026-9
更新日期：1999-01-01 00:00:00
abstract：:Holmium microspheres have recently become available in the European market as the third type of microspheres for radioembolization of unresectable liver malignancies. Holmium microspheres come with a dedicated administration system, and since these microspheres contain holmium-166 (166Ho) instead of yttrium-90, unique...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2019-05-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1053/j.semnuclmed.2010.05.001
更新日期：2010-09-01 00:00:00
abstract：:Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in a...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2018.10.007
更新日期：2019-01-01 00:00:00
abstract：:Radiation and concurrent chemoradiation are essential in the treatment of head and neck cancers because they allow a potentially curative organ preservation approach in a manner that greatly affects quality of life. Greater doses of radiation to areas of gross disease have invariably led to greater loco-regional contr...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2007.11.002
更新日期：2008-03-01 00:00:00
abstract：:In the past, T3 suppression testing was often required to confirm the presence of autonomous thyroid function in patients with borderline clinical and laboratory findings suggestive of hyperthyroidism or in euthyroid patients with the stigmata of Graves' disease. Similarly, TSH stimulation testing was used to document...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(81)80043-8
更新日期：1981-04-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(97)80033-5
更新日期：1997-01-01 00:00:00
abstract：:Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucos...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2011.02.003
更新日期：2011-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(89)80015-7
更新日期：1989-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(81)80027-x
更新日期：1981-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2014.04.001
更新日期：2014-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2014.07.006
更新日期：2015-01-01 00:00:00
abstract：:Bone scintigraphy of the hands and wrists represents an important adjunct imaging technique that complements plain film radiographic examination. The use of the three-phase bone scan provides clinical information not only regarding osseous uptake but the blood flow and extravascular distribution of the radiotracer as ...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(98)80016-0
更新日期：1998-01-01 00:00:00
abstract：:The short range and high linear energy transfer of α-particles offer the potential for efficient tumor killing while sparing normal bystander cells. Hematologic malignancies are ideally suited to targeted α-particle therapy (TAT) due to easy accessibility of malignant cells in blood, bone marrow, lymph nodes, and sple...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2019.09.002
更新日期：2020-03-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2009.11.002
更新日期：2010-03-01 00:00:00
abstract：:Detection of acute myocardial infarction as an area of increased activity has intrigued investigators for some time. Initial attempts with 203Hg-chlormerodrin and 203Hg-fluorescein analogues were successful in man. More recently, however, successful imaging of the acute myocardial infarct has been achieved with severa...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(77)80005-6
更新日期：1977-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(03)00032-1
更新日期：2003-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2006.03.002
更新日期：2006-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2003.09.008
更新日期：2004-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：1992-10-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：1994-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2007.09.002
更新日期：2008-01-01 00:00:00
abstract：:Several antineuroblastoma monoclonal antibodies (MoAbs) have been described and two have been used in radioimmunoimaging and radioimmunotherapy in patients. MoAb 3F8 is a murine IgG3 antibody specific for the ganglioside GD2. Radioiodine-labeled 3F8 has been shown to specifically target human neuroblastoma in patients...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(89)80021-2
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abstract：:Breast cancer is the most common cause of bone metastases in women. Imaging studies are useful to identify bone involvement and associated complications, for follow-up of disease spread and for the assessment of response to therapy. Bone scintigraphy with (99m)technetium-labeled diphosphonates is most widely used, due...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2009.05.002
更新日期：2009-11-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80155-2
更新日期：1992-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(82)80015-9
更新日期：1982-10-01 00:00:00
abstract：:There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologica...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(76)80034-7
更新日期：1976-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2020.03.001
更新日期：2020-07-01 00:00:00
abstract：:Radioimmunotherapy is a promising new therapeutic option for the treatment of B-cell non-Hodgkin's lymphoma. Several monoclonal antibody and radionuclide conjugates, including I-131 tositumomab and Y-90 ibritumomab, have been investigated in clinical trials. Yttrium 90 ibritumomab tiuxetan (Zevalin; Biogen Idec Inc, C...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2003.11.001
更新日期：2004-01-01 00:00:00
