Myocardial infarct imaging with technetium-labeled complexes.


:Detection of acute myocardial infarction as an area of increased activity has intrigued investigators for some time. Initial attempts with 203Hg-chlormerodrin and 203Hg-fluorescein analogues were successful in man. More recently, however, successful imaging of the acute myocardial infarct has been achieved with several 99mTc complexes. A large group of radiotracers localize in acutely damaged tissue in various models of experimental infarction. From these data, a number of specific structural properties associated with infarct avidity have been identified; these include the presence of mercury and the structural configuration of the organic carrier.


Semin Nucl Med


Holman BL,Davis MA,Hanson RN




Has Abstract


1977-01-01 00:00:00














  • Design and Challenges of Radiopharmaceuticals.

    abstract::This review describes general concepts with regard to radiopharmaceuticals for diagnostic or therapeutic applications that help to understand the specific challenges encountered during the design, (radio)synthesis, in vitro and in vivo evaluation and clinical translation of novel radiopharmaceuticals. The design of a ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Vermeulen K,Vandamme M,Bormans G,Cleeren F

    更新日期:2019-09-01 00:00:00

  • 15O-Water PET MPI: Current Status and Future Perspectives.

    abstract::Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Maaniitty T,Knuuti J,Saraste A

    更新日期:2020-05-01 00:00:00

  • Positron emission tomography/computed tomography for target delineation in head and neck cancers.

    abstract::Radiation and concurrent chemoradiation are essential in the treatment of head and neck cancers because they allow a potentially curative organ preservation approach in a manner that greatly affects quality of life. Greater doses of radiation to areas of gross disease have invariably led to greater loco-regional contr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Ahn PH,Garg MK

    更新日期:2008-03-01 00:00:00

  • Thematic planning: the role of the International Atomic Energy Agency in promoting education, medical research, and technology transfer among nuclear medicine communities of developing countries.

    abstract::One of the major mechanisms of implementing the International Atomic Energy Agency's (IAEA) programs in nuclear medicine has been through coordinated research projects (CRPs). In recent years, the IAEA has initiated a new type of CRP, called Doctoral CRP, in an attempt to further improve the effectiveness of its progr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Padhy AK,Dondi M

    更新日期:2008-03-01 00:00:00

  • The use of personal computers in nuclear medicine.

    abstract::Consolidating personal computers (PCs) with nuclear medicine technology can create high computational power comparable with that produced by vendor-specific computer equipment, and at more affordable prices. The integration of a standard platform and operating system with a large installed base has enabled our departm...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Tello R,Potter JE,Hill TC

    更新日期:1994-01-01 00:00:00

  • Radionuclide-labeled red blood cells: current status and future prospects.

    abstract::Radiolabeling of red cells and their clinical and research application in nuclear medicine constitute an area of continued interest and steady growth during the past two decades. Significant advances have been made so that at the present time, radiolabels with sufficient in vitro and in vivo stability are available fo...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Srivastava SC,Chervu LR

    更新日期:1984-04-01 00:00:00

  • Current status of immunoscintigraphy in the detection of thrombosis and thromboembolism.

    abstract::This review describes the use of monoclonal antibodies (MoAbs) for immunoscintigraphic detection of thrombosis and thromboembolism. Two major groups of MoAbs have been tested: Antibodies directed against platelets and antibodies directed against fibrin. Several antiplatelet antibodies have been developed that are dire...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Koblik PD,De Nardo GL,Berger HJ

    更新日期:1989-07-01 00:00:00

  • Basic principles of computed axial tomography.

    abstract::Computer tomography (CT) is a radiological imaging method which yields transverse tomographic images reflecting with high accuracy the spatial distribution of x-ray attenuation in the part examined. The contrast resolution achieved by CT permits the visualization of soft tissue structure heretofore invisible with conv...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Ter-Pogossian MM

    更新日期:1977-04-01 00:00:00

  • In- and Y-DOTA-lanreotide: results and implications of the MAURITIUS trial.

    abstract::The high-level expression of somatostatin receptors (SSTR) on various tumor cells has provided the molecular basis for successful use of radiolabeled peptide analogues as tumor tracers in nuclear medicine. The vast majority of human tumors seem to overexpress one or the other of 5 distinct hSSTR subtype receptors. Whe...

    journal_title:Seminars in nuclear medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Virgolini I,Britton K,Buscombe J,Moncayo R,Paganelli G,Riva P

    更新日期:2002-04-01 00:00:00

  • Quantitative planar thallium-201 stress scintigraphy: a critical evaluation of the method.

    abstract::The results of quantitative analysis of planar thallium-201 stress scintigraphy are superior to those of visual analysis. The increased sensitivity for detection of coronary artery disease is associated with maintenance of specificity. Consequently, we believe that quantitative analysis is the state-of-the-art for pla...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Wackers FJ,Fetterman RC,Mattera JA,Clements JP

    更新日期:1985-01-01 00:00:00

  • Neurochemical imaging of dementias.

    abstract::Neurochemical imaging is one of the most established "molecular" imaging techniques. There have been tremendous efforts expended to develop radioligands specific to each neurochemical system. Investigational applications of neurochemical imaging in dementing disorders are extensive. Cholinergic, dopaminergic, and sero...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Minoshima S,Frey KA,Cross DJ,Kuhl DE

    更新日期:2004-01-01 00:00:00

  • Molecular imaging of reporter gene expression in prostate cancer: an overview.

    abstract::Prostate cancer remains an important and growing health problem. Advances in imaging of prostate cancer may help to achieve earlier and more accurate diagnosis and treatment. We review the various strategies using reporter genes for molecular imaging of prostate cancer. These approaches are emerging as valuable tools ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Singh A,Massoud TF,Deroose C,Gambhir SS

    更新日期:2008-01-01 00:00:00

  • Monoclonal antibodies and neuroblastoma.

    abstract::Several antineuroblastoma monoclonal antibodies (MoAbs) have been described and two have been used in radioimmunoimaging and radioimmunotherapy in patients. MoAb 3F8 is a murine IgG3 antibody specific for the ganglioside GD2. Radioiodine-labeled 3F8 has been shown to specifically target human neuroblastoma in patients...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Miraldi F

    更新日期:1989-10-01 00:00:00

  • Current advances in vasodilator pharmacological stress perfusion imaging.

    abstract::More than 7 million stress perfusion studies are performed in the United States annually, 44% with pharmacological vasodilator stress agents. Both adenosine and dipyridamole are nonselective coronary vasodilators that are commonly used for stress perfusion imaging. These agents are safe and provide an effective means ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Druz RS

    更新日期:2009-05-01 00:00:00

  • Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III).

    abstract::In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magneti...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,多中心研究,评审


    authors: Stein PD,Gottschalk A,Sostman HD,Chenevert TL,Fowler SE,Goodman LR,Hales CA,Hull RD,Kanal E,Leeper KV Jr,Nadich DP,Sak DJ,Tapson VF,Wakefield TW,Weg JG,Woodard PK

    更新日期:2008-11-01 00:00:00

  • Imaging for Target Delineation in Head and Neck Cancer Radiotherapy.

    abstract::The definition of tumor involved volumes in patients with head and neck cancer poses great challenges with the increasing use of highly conformal radiotherapy techniques eg, volumetric modulated arc therapy and intensity modulated proton therapy. The risk of underdosing the tumor might increase unless great care is ta...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Jensen K,Al-Farra G,Dejanovic D,Eriksen JG,Loft A,Hansen CR,Pameijer FA,Zukauskaite R,Grau C

    更新日期:2021-01-01 00:00:00

  • FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3'-deoxy-3'-[18F]fluorothymidine.

    abstract::Positron emission tomography (PET) using the radiotracer 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) can image cellular proliferation in human cancers in vivo. FLT uptake has been shown to correlate with pathology-based proliferation measurements, including the Ki-67 score, in a variety of human cancers. Unlike pathology...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Salskov A,Tammisetti VS,Grierson J,Vesselle H

    更新日期:2007-11-01 00:00:00

  • Transition from planar to SPECT V/Q scintigraphy: rationale, practicalities, and challenges.

    abstract::Compared with planar imaging, ventilation/perfusion scintigraphy performed with single-photon emission computed tomography (SPECT) has a greater sensitivity and specificity, greater accuracy, improved reproducibility, and a lower number of inconclusive reports in the detection of pulmonary embolism. Despite these impr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Roach PJ,Bailey DL,Schembri GP,Thomas PA

    更新日期:2010-11-01 00:00:00

  • Nuclear medicine and diabetic foot infections.

    abstract::Up to 25% of the diabetic population is at risk for developing a pedal ulcer. These ulcers serve as a portal of entry for osteomyelitis and overlie more than 90% of diabetic pedal osteomyelitis cases. The diagnosis of osteomyelitis often is overlooked, and imaging studies are an essential part of the evaluation. The m...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Palestro CJ,Love C

    更新日期:2009-01-01 00:00:00

  • Hysterosalpingo-radionuclide scintigraphy (HERS).

    abstract::A radionuclide procedure, hysterosalpingo-radionuclide scintigraphy (HERS), was designed to evaluate the migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries as well as to image and functionally outline the patency of the pathways between these two extremes of the female r...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Iturralde M,Venter PF

    更新日期:1981-10-01 00:00:00

  • Gallium and other agents in diseases of the lung.

    abstract::The use of gallium for pulmonary diseases is hampered by its relative lack of specificity, typical 1- to 3-day delay between injection and imaging time, and suboptimal imaging characteristics. Other nuclear and nonnuclear imaging modalities, such as (18)F-fluorodeoxyglucose positron emission tomography (PET) and high-...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Schuster DM,Alazraki N

    更新日期:2002-07-01 00:00:00

  • Emergence of "Big Data" and Its Potential and Current Limitations in Medical Imaging.

    abstract::Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. Whi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Yaffe MJ

    更新日期:2019-03-01 00:00:00

  • Molecular Imaging for Primary Staging of Prostate Cancer.

    abstract::According to SEER Cancer Statistics Review there are around 165,000 new prostate cancer cases estimated in 2018 accounting for 9.5% of all newly diagnosed cancers. Accurate staging of primary prostate cancer is important for therapy selection (local vs systemic). Recent developments in molecular imaging may significan...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Pomykala KL,Farolfi A,Hadaschik B,Fendler WP,Herrmann K

    更新日期:2019-07-01 00:00:00

  • Infection control in the Department of Nuclear Medicine.

    abstract::Concern about the spread of infections in the hospital setting has prompted regulatory agencies to mandate infection control standards. Each hospital department is required to have written policies and procedures which describe measures to prevent and control the spread of nosocomial infections (hospital acquired infe...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Adams A,Egan A

    更新日期:1988-10-01 00:00:00

  • SPECT/CT in the Postoperative Painful Knee.

    abstract::This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy,...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: van der Bruggen W,Hirschmann MT,Strobel K,Kampen WU,Kuwert T,Gnanasegaran G,Van den Wyngaert T,Paycha F

    更新日期:2018-09-01 00:00:00

  • Dose Estimation in Pediatric Nuclear Medicine.

    abstract::The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Fahey FH,Goodkind AB,Plyku D,Khamwan K,O'Reilly SE,Cao X,Frey EC,Li Y,Bolch WE,Sgouros G,Treves ST

    更新日期:2017-03-01 00:00:00

  • An overview of the contribution of regional cerebral blood flow studies in cerebrovascular disease: is there a role for single photon emission computed tomography?

    abstract::Regional cerebral blood flow (rCBF) findings and their application to cerebrovascular disease are reviewed. Although the coupling of cerebral blood flow and metabolism are best studied with positron emission tomography, single-photon emission computed tomography measurements of rCBF can contribute to patient managemen...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Hellman RS,Tikofsky RS

    更新日期:1990-10-01 00:00:00

  • Gallium-67 scanning in the clinical evaluation of human immunodeficiency virus infection: indications and limitations.

    abstract::This review, examines the indications for and limitations of gallium-67 (67Ga) scanning in the evaluation of patients infected with human immunodeficiency virus (HIV). The imaging protocol, as well as the normal biodistribution of 67Ga and its normal variants are discussed. The diagnostic significance of the different...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Bekerman C,Bitran J

    更新日期:1988-10-01 00:00:00

  • Breast cancer: role of SPECT and PET in imaging bone metastases.

    abstract::Breast cancer is the most common cause of bone metastases in women. Imaging studies are useful to identify bone involvement and associated complications, for follow-up of disease spread and for the assessment of response to therapy. Bone scintigraphy with (99m)technetium-labeled diphosphonates is most widely used, due...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Ben-Haim S,Israel O

    更新日期:2009-11-01 00:00:00

  • Radioimmunotherapy for Prostate Cancer--Current Status and Future Possibilities.

    abstract::Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Evans-Axelsson S,Timmermand OV,Bjartell A,Strand SE,Elgqvist J

    更新日期:2016-03-01 00:00:00