Abstract：
:Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. While initially these CT images were relatively small, comprised of only about 6400 pixels per slice, the steady move toward higher spatial resolution, multislice imaging, digital radiography, and fluoroscopy rapidly increased the size of images and the amount of data required to be stored, processed, displayed, and moved about in a medical imaging department. The more recent introduction of digital pathology with submicron-sized pixels and the need for color further increases these demands. Rising work volumes in hospital, a push for cost containment, and a move toward greater precision in diagnosis and treatment of disease all work together to motivate the development of automated image analysis algorithms and techniques to improve efficiencies in in vivo imaging and pathology. This may require bringing together information from different imaging and nonimaging sources within the institution. While technological development has provided practical means for storage of the burgeoning data load and the use of multiple processors and high-speed networks has enabled more sophisticated analysis locally or in the cloud, challenges remain in terms of the ability to integrate data from different systems, the development of appropriately annotated image bases for training and testing of algorithms, and issues around privacy and ownership in obtaining access to patient-related data.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Yaffe MJdoi
10.1053/j.semnuclmed.2018.11.010subject
Has Abstractpub_date
2019-03-01 00:00:00pages
94-104issue
2eissn
0001-2998issn
1558-4623pii
S0001-2998(18)30099-0journal_volume
49pub_type
杂志文章,评审abstract：:Recent advances in the efficient production of high purity radioiodine (123I) and new efficient radiolabeling techniques have allowed the development of new classes of cardiovascular radiopharmaceuticals. These include 123I-labeled fatty acids to assess myocardial metabolism, 123I-metaiodobenzylguanidine (MIBG) for my...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80165-5
更新日期：1990-04-01 00:00:00
abstract：:Monoclonal antibody (MoAb) imaging has contributed greatly to the diagnosis and staging of both colorectal and ovarian cancers, and recently has been tested in patients with prostate cancer. Anatomic imaging modalities such as computed tomography, ultrasound, and magnetic resonance imaging have deficiencies in imaging...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80019-4
更新日期：1994-10-01 00:00:00
abstract：:The objective of this work is to compare the characteristics of various techniques for functional renal imaging, with a focus on nuclear medicine and magnetic resonance imaging. Even with low spatial resolution and rather poor signal-to-noise ratio, classical nuclear medicine has the advantage of linearity and good se...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2010.08.003
更新日期：2011-01-01 00:00:00
abstract：:2-deoxy-2-[18F] fluoro-D-glucose (18FDG) was developed in 1976 in a collaboration between scientists at the National Institutes of Health, the University of Pennsylvania, and Brookhaven National Laboratory. It was developed for the specific purpose of mapping brain glucose metabolism in living humans, thereby serving ...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/snuc.2002.29270
更新日期：2002-01-01 00:00:00
abstract：:In the past 20 years there have been great advances in our understanding of the molecular genetics of gastrointestinal tumors. In general, cancers develop and proliferate due to: driver mutations or related alterations in the genome resulting in overactivity of oncogenes, underactivity of tumor suppressor genes allowi...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2020.06.002
更新日期：2020-09-01 00:00:00
abstract：:Much efficacy is gained in clinical practice if a single agent can be used for both diagnosis and therapy, a practice termed theranostics. Metaiodobenzylguanidine (mIBG), a norepinephrine analogue with high sensitivity and specificity for neuroblastoma, is an exemplar of theranostics. The physiologic biodistribution o...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2016.02.002
更新日期：2016-05-01 00:00:00
abstract：:The concept of brain death has gained importance in the past few decades to prevent futile attempts to sustain ventilation and blood circulation when the brain has lost all function and to procure beneficial tissues or life-saving organs for transplantation. However, differences remain among professional societies and...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2011.07.007
更新日期：2012-01-01 00:00:00
abstract：:Positron emission tomography (PET) using the radiotracer 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) can image cellular proliferation in human cancers in vivo. FLT uptake has been shown to correlate with pathology-based proliferation measurements, including the Ki-67 score, in a variety of human cancers. Unlike pathology...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2007.08.001
更新日期：2007-11-01 00:00:00
abstract：:The results of quantitative analysis of planar thallium-201 stress scintigraphy are superior to those of visual analysis. The increased sensitivity for detection of coronary artery disease is associated with maintenance of specificity. Consequently, we believe that quantitative analysis is the state-of-the-art for pla...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(85)80043-x
更新日期：1985-01-01 00:00:00
abstract：:Epilepsy is the most common serious brain disorder in children, occurring in all parts of the world and within every stratum of the population. Through its effects, it exerts a significant physical, psychological, economic, and social toll on children and their caregivers. Historically, the surgical treatment of epile...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2012.06.005
更新日期：2012-11-01 00:00:00
abstract：:Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgk...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2017.09.007
更新日期：2018-01-01 00:00:00
abstract：:Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. In those patients an accur...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2018.07.004
更新日期：2018-11-01 00:00:00
abstract：:The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2016.10.006
更新日期：2017-03-01 00:00:00
abstract：:In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients ar...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2016.01.003
更新日期：2016-07-01 00:00:00
abstract：:The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2014.03.008
更新日期：2014-05-01 00:00:00
abstract：:Nuclear medicine imaging techniques continue to play a unique role in the evaluation of hepatic masses. Although many useful radiodiagnostic agents are available, the predominant nuclear medicine study used to evaluate hepatic masses in this decade is technetium-labeled red blood cell "blood-pool" scintigraphy. Hepati...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(96)80012-2
更新日期：1996-01-01 00:00:00
abstract：:The best option for the treatment of end-stage renal disease is kidney transplantation. Prompt diagnosis and management of early posttransplantation complications is of utmost importance for graft survival. Biochemical markers, allograft biopsies, and imaging modalities are used for the timely recognition and manageme...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2013.10.005
更新日期：2014-03-01 00:00:00
abstract：:In order to assess the role of 99mTc-iminodiacetic acid (IDA) cholescintigraphy in evaluating postoperative patients, a total of 213 studies were performed in 189 patients over a 3-year time period. Of these, 130 studies were obtained in 125 cases with signs and/or symptoms suggesting postcholecystectomy syndrome. A n...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(82)80027-5
更新日期：1982-01-01 00:00:00
abstract：:Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as we...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:New software methods that incorporate iterative reconstruction, resolution recovery, and noise compensation now provide the ability to maintain or improve myocardial perfusion SPECT image quality with conventional sodium iodide cameras. Despite lower image counting statistics associated with significantly decreased in...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2014.04.001
更新日期：2014-07-01 00:00:00
abstract：:Radionuclide angiocardiography and myocardial perfusion imaging with exercise are valuable methods to assess patients undergoing percutaneous transluminal coronary angioplasty. Successful angioplasty results in improvement in ventricular systolic and diastolic function and regional perfusion. Complications of angiopla...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80048-0
更新日期：1991-04-01 00:00:00
abstract：:There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologica...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(76)80034-7
更新日期：1976-01-01 00:00:00
abstract：:Carcinoma of the lung is one of the most frequent malignancies and a major cause of mortality. The use of positron emission tomography (PET) has been extensively investigated in patients with carcinoma of the lung and has established clinical utility and cost-effectiveness in characterization of solitary pulmonary nod...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/snuc.2002.126059
更新日期：2002-10-01 00:00:00
abstract：:Sickling of erythrocytes in patients with S-hemoglobin causes marrow and bone infarction. The former can be demonstrated as a lack of 99mTc-sulfur colloid uptake on marrow imaging examination. These defects may resolve or persist long after the acute episode. If the bone is involved in the acute episode, imaging withi...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(76)80038-4
更新日期：1976-01-01 00:00:00
abstract：:Rhenium-186 (tin)hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in skeletal metastases in patients with advanced cancer. A single intravenous administration of approximately 34 mCi (1,258 MBq) resulted in significant improvement in pain in 33 of 43 evaluable patients (77%) following...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80155-2
更新日期：1992-01-01 00:00:00
abstract：:Vital blue dyes were used to show the feasibility and accuracy of intraoperative lymphatic mapping of the sentinel node (SN) in patients with melanoma, breast cancer, and other solid tumors. Surgeons who have successfully completed an adequate number of cases of intraoperative mapping and sentinel lymph node dissectio...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(00)80058-6
更新日期：2000-01-01 00:00:00
abstract：:Although planar radionuclide techniques provide accurate, noninvasive measurements of myocardial perfusion and function that are of proven clinical value in the evaluation of the cardiac patient, they are limited by poor object contrast and superimposition of surrounding structures. Due to incomplete angular sampling ...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(87)80034-x
更新日期：1987-07-01 00:00:00
abstract：:Evaluation of ventricular performance is essential in the diagnosis and long-term management of patients with heart disease. This can be most easily performed clinically using simple tools. When more definitive objective assessment of cardiac function is indicated, the equilibrium gated blood pool study provides relia...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
doi：10.1016/s0001-2998(79)80015-x
更新日期：1979-10-01 00:00:00
abstract：:The diphosphonate bone scan is ideally suited to assess many global, focal or multifocal metabolic bone disorders and there remains a role for conventional bone scintigraphy in metabolic bone disorders at diagnosis, investigation of complications, and treatment response assessment. In contrast, the role of bone scinti...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1053/j.semnuclmed.2009.08.002
更新日期：2010-01-01 00:00:00
abstract：:Regional cerebral blood flow (rCBF) findings and their application to cerebrovascular disease are reviewed. Although the coupling of cerebral blood flow and metabolism are best studied with positron emission tomography, single-photon emission computed tomography measurements of rCBF can contribute to patient managemen...
journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(05)80236-3
更新日期：1990-10-01 00:00:00
