Abstract:
OBJECTIVES:Poor treatment response is an important factor contributing to lack of treatment adherence. The goals of this research were to determine whether improvements in Positive and Negative Syndrome Scale (PANSS) symptom domains predict the likelihood of staying on treatment and whether differential responses to treatment with various atypical antipsychotics in specific symptom domains account for differences in discontinuation rates or treatment adherence. METHODS:We conducted a post-hoc analysis of pooled data from 5 randomized, double-blind, 24- to 28-week clinical trials in 1103 olanzapine-treated and 1090 risperidone-, quetiapine-, ziprasidone-, or aripiprazole-treated adult patients with schizophrenia. The 5 PANSS factors were tested as potential predictors of treatment adherence for all treatment groups combined. Treatment differences in the 5 PANSS factors and individual items were assessed between olanzapine and the other atypical antipsychotics combined. Secondary analyses repeated for the 21 Heinrichs Quality of Life Scale (QLS) items. RESULTS:Improvement in PANSS positive factor was the strongest predictor of treatment adherence, irrespective of medication (based on standardized scores, hazard ratio [HR], 1.58; 95% confidence interval [CI], +1.40 to +1.79; P < .001). Improvement in PANSS hostility (HR, 1.23; 95% CI, +1.11 to +1.37; P < .001) and depressive (HR, 1.15; 95% CI, +1.05 to +1.27; P = .002) factors was also a significant predictor; negative and disorganized thoughts factors were not. All QLS items had significant predictive effects. Olanzapine-treated patients showed significantly greater improvements than all other groups at week 24 on all 5 PANSS factors (P = .028 for negative; P < .001 for all others) and on 3 QLS items. CONCLUSION:Significant improvement in positive symptoms, regardless of treatment, followed by significant improvement in hostility and depressive symptoms, may best predict treatment adherence. Olanzapine-treated patients experienced significantly greater improvements in these specific symptoms than patients treated with the other atypical antipsychotics examined. These findings may further explain why olanzapine-treated patients continue treatment more often.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Liu-Seifert H,Osuntokun OO,Feldman PDdoi
10.1016/j.comppsych.2010.12.003subject
Has Abstractpub_date
2012-01-01 00:00:00pages
107-15issue
1eissn
0010-440Xissn
1532-8384pii
S0010-440X(10)00205-1journal_volume
53pub_type
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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abstract::Schizophrenia is present in all human populations with approximately the same incidence. Why does such illness persist given that it is associated with a reproductive disadvantage? What is the balancing advantage? A possible explanation is linked to human language. According to this hypothesis schizophrenia occurs as ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:A new diagnostic category called Hoarding Disorder (HD) has been proposed for inclusion in DSM-5. It is paramount that this addition does not result in an over-pathologization of normative behavior. Collectors constitute a valid population within which to test the diagnostic boundaries of HD. The current stud...
journal_title:Comprehensive psychiatry
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abstract::The purpose of this study was to examine whether performance on a standard cognitive test-battery can be used to clearly separate higher functioning autism from schizophrenia. Revised Wechsler Intelligence Scale for Children (WISC-R) or Adults (WAIS-R) profiles of 20 autistic and 20 schizophrenic adolescent young adul...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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abstract::The Defense Style Questionnaire (DSQ) assesses defensive behavior by empirically evaluating conscious derivatives of defense and coping mechanisms in everyday life. It was developed on the assumption that defenses can be ordered along a maturity-immaturity continuum and tend to group into clusters, or defensive styles...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.07.012
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.11.017
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2007.05.016
更新日期:2008-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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abstract:BACKGROUND:Limited data are available examining the relationship between mental state disorders (mood, anxiety, substance use, eating disorders), their co-occurrence with personality disorder (PD), and quality of life among women. We aimed to investigate these relationships in a sample of women from the community. MET...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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abstract::The rates of comorbid personality disorders in patients with panic disorder are reported to be elevated, have an adverse impact on the response to treatment, and increase the likelihood of relapse on treatment discontinuation. We examined the rates of personality disorders in panic disorder patients in a longitudinal,...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(92)90002-8
更新日期:1992-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.07.010
更新日期:2013-04-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.comppsych.2014.01.001
更新日期:2014-05-01 00:00:00
abstract::Our aim was to describe the clinical features of 35% CO2-induced panic attacks in patients with panic disorder (PD) (Diagnostic and Statistical Manual and Mental Disorders, Fourth Edition) and compare them with the last spontaneous panic attack in patients with PD who had not had a panic attack after the 35% CO2 chall...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.comppsych.2005.07.007
更新日期:2006-05-01 00:00:00
abstract::The covariation patterns of DSM-IV personality disorders (PDs) were studied in 431 consecutively admitted psychiatric patients. The co-occurrence rate was greater than 50% for all DSM-IV PDs. Both bivariate association tests and loglinear models showed distinct significant covariation patterns among PDs which were sta...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/S0010-440X(00)90049-X
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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abstract:INTRODUCTION:Dopamine receptor polymorphisms have been associated with specific patterns of novelty seeking (NS) temperamental nature and frontal executive function. In addition, carriers of dopamine receptor type 2 (DRD2)-TaqI A1 have been hypothesized to be potentially vulnerable to addictive behaviors. In the presen...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.01.008
更新日期:2008-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2016.07.003
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:This study aimed to describe, compare, and predict mental health outcomes of different migrant groups and native residents in Switzerland. SUBJECTS AND METHODS:Asylum seekers (n=65); refugees holding permanent protection visas (n=34); illegal migrants (n=21); labor migrants (n=26); and residents (n=56) complet...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.02.003
更新日期:2014-05-01 00:00:00
abstract::The aim of this study was to evaluate psychometric properties and relations between two different methods of measuring alexithymia and one measure of emotional awareness in a German non-clinical sample. The 20-Item Toronto Alexithymia Scale (TAS-20), the Toronto Structured Interview for Alexithymia (TSIA), and the Lev...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.12.013
更新日期:2014-05-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.08.006
更新日期:2018-01-01 00:00:00
abstract::We do not see the world as it is. Perception forms a subjective image of the world in a language that has proven to be adaptive to our interaction with the external world. Perception is mainly determined by current needs of the organism and goals of behavior. Sensory processing itself does not culminate in perception ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(98)90067-0
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Compared to other mental illnesses, bipolar disorder is associated with a disproportionately high rate of substance use disorders (SUDs), and the co-occurrence is associated with significant morbidity and mortality. Early diagnosis of primary bipolar disorder may provide opportunities for SUD prevention, but...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.12.008
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Theory of mind (ToM) can be divided into cognitive and affective ToM, and a distinction can be made between overmentalizing and undermentalizing errors. Research has shown that ToM in schizophrenia is associated with non-social and social cognition, and with clinical symptoms. In this study, we investigate c...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2018.05.002
更新日期:2018-08-01 00:00:00
abstract::Fire-setting is a serious and costly form of antisocial behavior. Our objective in this study was to examine the prevalence and correlates of intentional fire-setting behavior in the United States. Data were derived from a nationally representative sample of US residents 18 years and older. Structured psychiatric inte...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2009.06.002
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:It is well documented that patients with schizophrenia have impoverished quality of life (QOL). Efforts to determine the underpinnings of this impoverishment have implicated negative symptoms more than positive or disorganized symptoms. However, only a minority of individuals with the liability to schizophren...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.11.002
更新日期:2009-09-01 00:00:00