Abstract:
OBJECTIVES:Poor treatment response is an important factor contributing to lack of treatment adherence. The goals of this research were to determine whether improvements in Positive and Negative Syndrome Scale (PANSS) symptom domains predict the likelihood of staying on treatment and whether differential responses to treatment with various atypical antipsychotics in specific symptom domains account for differences in discontinuation rates or treatment adherence. METHODS:We conducted a post-hoc analysis of pooled data from 5 randomized, double-blind, 24- to 28-week clinical trials in 1103 olanzapine-treated and 1090 risperidone-, quetiapine-, ziprasidone-, or aripiprazole-treated adult patients with schizophrenia. The 5 PANSS factors were tested as potential predictors of treatment adherence for all treatment groups combined. Treatment differences in the 5 PANSS factors and individual items were assessed between olanzapine and the other atypical antipsychotics combined. Secondary analyses repeated for the 21 Heinrichs Quality of Life Scale (QLS) items. RESULTS:Improvement in PANSS positive factor was the strongest predictor of treatment adherence, irrespective of medication (based on standardized scores, hazard ratio [HR], 1.58; 95% confidence interval [CI], +1.40 to +1.79; P < .001). Improvement in PANSS hostility (HR, 1.23; 95% CI, +1.11 to +1.37; P < .001) and depressive (HR, 1.15; 95% CI, +1.05 to +1.27; P = .002) factors was also a significant predictor; negative and disorganized thoughts factors were not. All QLS items had significant predictive effects. Olanzapine-treated patients showed significantly greater improvements than all other groups at week 24 on all 5 PANSS factors (P = .028 for negative; P < .001 for all others) and on 3 QLS items. CONCLUSION:Significant improvement in positive symptoms, regardless of treatment, followed by significant improvement in hostility and depressive symptoms, may best predict treatment adherence. Olanzapine-treated patients experienced significantly greater improvements in these specific symptoms than patients treated with the other atypical antipsychotics examined. These findings may further explain why olanzapine-treated patients continue treatment more often.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Liu-Seifert H,Osuntokun OO,Feldman PDdoi
10.1016/j.comppsych.2010.12.003subject
Has Abstractpub_date
2012-01-01 00:00:00pages
107-15issue
1eissn
0010-440Xissn
1532-8384pii
S0010-440X(10)00205-1journal_volume
53pub_type
杂志文章abstract::Although previous studies have suggested the inadequacy of the two-factor models of positive and negative symptoms in schizophrenia, confirmatory testing of the putative three-factor models is needed. Using a sample of 193 individuals diagnosed with schizophrenia, this study tested the relative goodness-of-fit of one-...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(94)90016-7
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:A number of studies about attention-deficit/hyperactivity disorder (ADHD) and Internet video game play have examined the prefrontal cortex and dopaminergic system. Stimulants such as methylphenidate (MPH), given to treat ADHD, and video game play have been found to increase synaptic dopamine. We hypothesized ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.08.011
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Tonic immobility is an involuntary response to inescapable life-threatening events. Peritraumatic tonic immobility has been reported in convenience samples of female victims of sexual assault and in mixed-gender victims of different types of trauma. This study evaluated peritraumatic tonic immobility in a re...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2015.04.001
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Various factors contribute to suicide. Psychological strains are hypothesized to precede suicidal thought and attempt. Life satisfaction can be a measure of relative deprivation strain and aspiration-reality strain. AIMS:This study was to compare the suicide attempters with various levels of life satisfacti...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2016.12.002
更新日期:2017-04-01 00:00:00
abstract::Although both suicide ideation (SI) and non-suicidal self-injury (NSSI) are known risk factors for suicidal behavior, few longitudinal studies have examined whether having a history of one or both of these factors prospectively predicts increased risk for suicide attempts. According to the theory of acquired capabilit...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.12.011
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Most diagnostic interviews depend on recall of past symptoms and may be vulnerable to recall bias. The objective of this study was to describe the epidemiology of major depression using an approach that is less reliant on recall using an assessment scale, the 9-item Brief Patient Health Questionnaire (PHQ-9)...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.05.012
更新日期:2009-01-01 00:00:00
abstract::Previous studies of cognitive functioning in bipolar disorder generally indicate that a more severe course of illness is associated with greater cognitive impairment. In particular, a history of greater number and longer duration of mood episodes predicts enduring cognitive deficits in euthymic patients. Shifting the ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.09.005
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:This study aimed to examine the prevalence of pre-marital sex and its predicting factors among youth trainees undergoing a national skill training programme in the state of Malaysia. METHODS:Participants filled up health screening surveys at the beginning of their training period. A total of 1328 out of 1...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.03.008
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Problem gambling is common across cultures, and has been conceptualized in terms of impulsivity. While elevated rates of attention deficit hyperactivity disorder (ADHD) have been observed in problem gamblers, the relationship between these two conditions, and other dissociable forms of impulsivity, has recei...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.10.013
更新日期:2015-02-01 00:00:00
abstract::The relationship between obsessive-compulsive disorder (OCD) and putative obsessive-compulsive (OC) spectrum disorders is unclear. This study investigates the prevalence of putative OC spectrum disorders in OCD subjects in a controlled clinical design. The putative OC spectrum disorders studied included somatoform dis...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/S0010-440X(03)00084-1
更新日期:2003-07-01 00:00:00
abstract::We have reported elsewhere the development of a brief version of the Parental Bonding Instrument (PBI), which we have called the Parental Bonding Instrument-Brief Current form (PBI-BC), for use in survey research in adolescent samples. It was shown in that report that PBI-BC retained the factor structure of the origin...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(92)90059-y
更新日期:1992-11-01 00:00:00
abstract::From a total sample of 1,448 psychiatric outpatients, 175 (12.1%) received a diagnosis of a somatoform disorder according to DSM-III-R criteria. One hundred twenty-two (70%) of these patients had another current axis I diagnosis, and this rate increased to 79% (139 of 175) when lifetime psychiatric diagnoses were reco...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(99)90131-1
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals a...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2019.152143
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:With the rate of obesity on the rise worldwide, individuals with schizophrenia represent a particularly vulnerable population. The aim of this study was to assess the metabolic profile of individuals with schizophrenia in relation to dietary and physical activity habits compared with healthy controls. METHOD...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.02.003
更新日期:2012-10-01 00:00:00
abstract::The goal of this study is to replicate an earlier epidemiological finding of seasonal changes in mood and behavior among Chinese medical students using an independent study population. Three hundred nineteen college students were surveyed with a Chinese version of the Seasonal Pattern Assessment Questionnaire (SPAQ) a...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(00)90132-9
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to study the psychometric properties of the Social Phobia Inventory (SPIN) in its version for the context of Brazilian adults. METHODS:A sample of Brazilian university students from the general population (n = 2314) and a sample of university students identified as cases (n = 88) and...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.03.004
更新日期:2010-11-01 00:00:00
abstract::A number of studies have examined the relationships between aggression and various facets of the work environment. However, to our knowledge, the relationship between self-reported aggressive behaviors and corresponding employment histories has never been previously explored. Using a cross-sectional approach and a sel...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.06.005
更新日期:2013-01-01 00:00:00
abstract::It has been hypothesized that college women are particularly susceptible to the development and maintenance of disturbed eating behaviors. The purpose of this study was to determine the frequency of disordered eating attitudes and eating disorders in a sample of Turkish female college students. The Eating Attitudes Te...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2005.05.004
更新日期:2006-03-01 00:00:00
abstract::It is widely appreciated that a social stigma surrounds psychiatric illness in contemporary society. Researchers have concentrated on the nature and consequences of psychiatric stigma. Although there exists much work on the social history of mental illness, stigma, per se, has not often been addressed in historical st...
journal_title:Comprehensive psychiatry
pub_type: 历史文章,杂志文章
doi:10.1016/0010-440x(90)90036-r
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Theory of mind (ToM) can be divided into cognitive and affective ToM, and a distinction can be made between overmentalizing and undermentalizing errors. Research has shown that ToM in schizophrenia is associated with non-social and social cognition, and with clinical symptoms. In this study, we investigate c...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2018.05.002
更新日期:2018-08-01 00:00:00
abstract::Some patients with Tourette's syndrome (TS) remain disabled despite conventional treatment. Recently, neurosurgical procedures have been reported to be potentially effective interventions for such intractable cases. Clinicians are now being asked to make recommendations to patients about these candidate operations. Th...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0010-440x(95)90109-4
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:The aim of this cross-sectional study was to examine the relationships between attitudes toward antipsychotics, insight, and other clinical variables in stable schizophrenia. METHODS:Fifty Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision-(DSM-IV-TR)-diagnosed schizophrenic...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2007.08.013
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:There are problems with the fatigue measures currently used in depressed patients. The Multidimensional Fatigue Inventory (MFI-20) covering general fatigue, physical fatigue, mental fatigue, reduced activity and reduced motivation has been widely used in patients with cancer and chronic fatigue syndrome. To ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.06.006
更新日期:2014-10-01 00:00:00
abstract::Obesity is associated with several symptoms that are components of the diagnostic criteria for major depressive disorder (MDD). Compared with nonobese individuals, obese individuals report more fatigue, sleep disturbance, and overeating. Obesity might, therefore, impact the psychometric properties of the MDD criteria....
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.05.001
更新日期:2011-03-01 00:00:00
abstract::Our aim was to describe the clinical features of 35% CO2-induced panic attacks in patients with panic disorder (PD) (Diagnostic and Statistical Manual and Mental Disorders, Fourth Edition) and compare them with the last spontaneous panic attack in patients with PD who had not had a panic attack after the 35% CO2 chall...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.comppsych.2005.07.007
更新日期:2006-05-01 00:00:00
abstract:AIMS:The aim of this study was to compare conversion disorder patients with healthy controls in terms of temperament and character, and to determine the effect of these characteristics on comorbid depression, based on the idea that conversion disorder patients may have distinctive temperament and character qualities. ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.10.007
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that parents' awareness of their offspring's schizophrenia could influence their offspring's insight. Low patient insight is linked to impairment of specific cognitive abilities, and biological parents of schizophrenia patients have impaired capacities in these same domains. However, l...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.02.013
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To investigate possible associations of alexithymia with marital satisfaction and mutual attachment between the partners in a group of parents-to-be during pregnancy. METHODS:The present study was conducted in a pregnancy cohort. Cross-sectional data were available for 151 mothers and 106 fathers, and altoge...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.03.019
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Fibromyalgia (FM) is a common syndrome whose main characteristic is chronic widespread musculoskeletal pain, the severity of which is frequently worsened by concomitant obesity. Major depression (MD), particularly as part of a bipolar spectrum disorder (BSD), is associated with both obesity and FM. OBJECTIV...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.08.006
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:A new diagnostic category called Hoarding Disorder (HD) has been proposed for inclusion in DSM-5. It is paramount that this addition does not result in an over-pathologization of normative behavior. Collectors constitute a valid population within which to test the diagnostic boundaries of HD. The current stud...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.07.063
更新日期:2013-04-01 00:00:00