Abstract:
BACKGROUND:Studies have shown that patients with schizophrenia are at a high risk of developing insulin resistance (IR). We investigated the prevalence of IR and its clinical correlates in hospitalized Chinese patients with schizophrenia. METHODS:A total of 193 patients with schizophrenia (113 males and 80 females) were recruited for the study. We collected their demographic and clinical data, including data on their plasma glucose and lipid levels. All patients were rated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess cognitive function, while Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathology. The cut-off value for the homeostasis model assessment of insulin resistance (HOMA-IR) was set at 1.7. RESULTS:The prevalence of IR was 37.82% (73/193). The IR patients had significantly higher waist-to-hip ratio and body mass index (BMI), and higher fasting plasma glucose (FPG), triglyceride (TG), and low density lipoprotein (LDL) levels compared to non-IR patients (all p<.05). Binary logistic regression analysis showed that smoking, BMI, and TG and LDL levels are significant predictors of IR. In addition, correlation analysis showed that IR was significantly correlated with the waist-to-hip ratio, BMI, and LDL level (Bonferroni corrected p<.05). The multivariable linear regression analysis indicated that the BMI and FPG are associated with the IR index. There was no significant difference in IR index between patients who were taking different antipsychotics. CONCLUSION:We found a high prevalence of IR and its risk factors in Chinese patients with schizophrenia. Active weight control to reduce the BMI and waist circumference and reducing the number of cigarettes consumed, may be essential to decrease the incidence of IR in patients with schizophrenia.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Lin C,Chen K,Zhang R,Fu W,Yu J,Gao L,Ni H,Song J,Chen Ddoi
10.1016/j.comppsych.2019.152145subject
Has Abstractpub_date
2020-01-01 00:00:00pages
152145eissn
0010-440Xissn
1532-8384pii
S0010-440X(19)30068-9journal_volume
96pub_type
杂志文章abstract::The study attempted to determine the extent of dissociative experiences and the prevalence of dissociative disorders (DDs) in a series of acute psychiatric inpatients and to correlate these experiences and disorders with some sociodemographic, clinical, and historical variables. A total of 207 consecutively admitted p...
journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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doi:10.1053/comp.2001.26271
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abstract:BACKGROUND:Although research on body dysmorphic disorder (BDD) is increasing, no follow-up studies of this disorder's course of illness have been published. METHODS:The status of 95 outpatients with BDD treated in a clinical practice was assessed by chart review. Standard scales were used to rate subjects at baseline ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.12.001
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.comppsych.2006.01.006
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pub_type: 杂志文章
doi:10.1016/j.comppsych.2015.08.005
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.09.005
更新日期:2009-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.08.052
更新日期:2014-11-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.09.005
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
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journal_title:Comprehensive psychiatry
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.12.003
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.10.007
更新日期:2013-05-01 00:00:00
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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更新日期:2014-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00