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Is there a relationship between clozapine and obsessive-compulsive disorder?: a retrospective chart review.

Abstract：

:The emergence of obsessive-compulsive symptoms during clozapine treatment has been reported in recent case studies, yet the incidence and significance of this finding is still unclear pending reliable data from a larger sample of patients. Hospital records of 142 randomly selected inpatients started on clozapine treatment at McLean Hospital before July 1, 1992, were reviewed retrospectively. Based on a limited retrospective chart review, there were no definitive cases of patients who developed obsessive-compulsive disorder (OCD) or whose OCD worsened as a result of clozapine treatment. Although some fluctuation of OCD symptoms may have occurred in two cases, it is unclear whether those symptoms were related to treatment with clozapine (or other psychotropic drugs) or to undulations in the natural history of OCD. No definitive relationship between OCD symptoms and clozapine treatment could be established in this limited study. Further clarification of this matter awaits outcome research using prospective methodologies.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Ghaemi SN,Zarate CA Jr,Popli AP,Pillay SS,Cole JO

doi

10.1016/s0010-440x(95)90071-3

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

267-70

issue

4

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(95)90071-3

journal_volume

36

pub_type

杂志文章

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