Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Abstract:

OBJECTIVES:There are problems with the fatigue measures currently used in depressed patients. The Multidimensional Fatigue Inventory (MFI-20) covering general fatigue, physical fatigue, mental fatigue, reduced activity and reduced motivation has been widely used in patients with cancer and chronic fatigue syndrome. To address the multidimensional nature of fatigue, we examined the validity and reliability of a Chinese version of the MFI-20 in major depressive disorder (MDD). METHODS:Data were derived from a randomized controlled trial of acupuncture in 137 patients with partially remitted MDD. The test-retest reliability, internal consistency, construct and concurrent validity and sensitivity to change of the MFI-20 were analyzed. RESULTS:The MFI-20 was found to have good internal consistency (Cronbach's alpha=0.89) and 1-week test-retest reliability (Pearson correlation of the total score=0.73). Factor analysis showed 5 factors, but the factor structure was different from that in medical conditions. The 2 most prominent factors, explaining 46% of the total variance, were both associated with physical and mental energy but different in directions. There were adequate concurrent validity and sensitivity to change as evidenced by the significant correlations between the MFI-20 scores and depressive and anxiety symptoms, general health and quality of life. CONCLUSION:The Chinese MFI-20 is a valid and reliable instrument for the assessment of fatigue in MDD patients with residual symptoms. The construct of fatigue in MDD seems to be different from that in medical conditions. Further studies are needed to examine the MFI-20 in MDD patients from other cultures.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Chung KF,Yu BY,Yung KP,Yeung WF,Ng TH,Ho FY

doi

10.1016/j.comppsych.2014.06.006

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1671-8

issue

7

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(14)00156-4

journal_volume

55

pub_type

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