Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.

Abstract:

BACKGROUND:Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. METHODS:We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort. RESULTS:Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identified four population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low (N=463, 29.5%); persistently high (N=371, 24%); decreasing (N=360, 23%); increasing (N=367, 23.5%). The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood. Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared with those with persistently low CRP; adjusted odds ratio (OR)=3.78 (95% Confidence Interval (CI), 1.46-9.81; p=0.006). The odds of moderate/severe depression were also increased for the persistently high CRP group, but this was not statistically significant; OR=2.54 (95% CI, 0.90-7.16). LIMITATIONS:Repeat CRP measures were available for a subset, who may not be representative of all cohort participants. CONCLUSIONS:The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Osimo EF,Stochl J,Zammit S,Lewis G,Jones PB,Khandaker GM

doi

10.1016/j.comppsych.2019.152143

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

152143

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(19)30066-5

journal_volume

96

pub_type

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