Abstract:
OBJECTIVE:Recent studies have suggested that the brain circuitry mediating cue-induced desire for video games is similar to that elicited by cues related to drugs and alcohol. We hypothesized that desire for Internet video games during cue presentation would activate similar brain regions to those that have been linked with craving for drugs or pathologic gambling. METHODS:This study involved the acquisition of diagnostic magnetic resonance imaging and functional magnetic resonance imaging data from 19 healthy male adults (age, 18-23 years) following training and a standardized 10-day period of game play with a specified novel Internet video game, "War Rock" (K2 Network, Irvine, CA). Using segments of videotape consisting of 5 contiguous 90-second segments of alternating resting, matched control, and video game-related scenes, desire to play the game was assessed using a 7-point visual analogue scale before and after presentation of the videotape. RESULTS:In responding to Internet video game stimuli, compared with neutral control stimuli, significantly greater activity was identified in left inferior frontal gyrus, left parahippocampal gyrus, right and left parietal lobe, right and left thalamus, and right cerebellum (false discovery rate <0.05, P < .009243). Self-reported desire was positively correlated with the β values of left inferior frontal gyrus, left parahippocampal gyrus, and right and left thalamus. Compared with the general players, subjects who played more Internet video game showed significantly greater activity in right medial frontal lobe, right and left frontal precentral gyrus, right parietal postcentral gyrus, right parahippocampal gyrus, and left parietal precuneus gyrus. Controlling for total game time, reported desire for the Internet video game in the subjects who played more Internet video game was positively correlated with activation in right medial frontal lobe and right parahippocampal gyrus. DISCUSSION:The present findings suggest that cue-induced activation to Internet video game stimuli may be similar to that observed during cue presentation in persons with substance dependence or pathologic gambling. In particular, cues appear to commonly elicit activity in the dorsolateral prefrontal, orbitofrontal cortex, parahippocampal gyrus, and thalamus.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Han DH,Bolo N,Daniels MA,Arenella L,Lyoo IK,Renshaw PFdoi
10.1016/j.comppsych.2010.04.004subject
Has Abstractpub_date
2011-01-01 00:00:00pages
88-95issue
1eissn
0010-440Xissn
1532-8384pii
S0010-440X(10)00037-4journal_volume
52pub_type
杂志文章abstract::Investigation of relationship patterns between co-occurring symptoms has greatly improved the efficacy of psychiatric care. Depression and anxiety often present together, and identification of primary vs secondary psychiatric symptoms has implications for treatment. Previous psychotherapy research investigating the re...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.comppsych.2008.06.009
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is often associated with significant psychiatric comorbidity. Comorbid disorders include mood and anxiety disorders as well as obsessive-compulsive spectrum disorders (OCSDs). This paper aims to investigate comorbidity of DSM Axis I-disorders, including OCSDs, in patients ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.05.020
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:A number of studies about attention-deficit/hyperactivity disorder (ADHD) and Internet video game play have examined the prefrontal cortex and dopaminergic system. Stimulants such as methylphenidate (MPH), given to treat ADHD, and video game play have been found to increase synaptic dopamine. We hypothesized ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.08.011
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Alcohol abuse and dependence are frequently associated with psychiatric disorders and personality disorders (PDs) with differences among gender. However, only few studies investigated gender differences in PDs among alcoholics. The aim of this study was to investigate PDs in a sample of patients accessing in...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2011.05.011
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:With the rate of obesity on the rise worldwide, individuals with schizophrenia represent a particularly vulnerable population. The aim of this study was to assess the metabolic profile of individuals with schizophrenia in relation to dietary and physical activity habits compared with healthy controls. METHOD...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.02.003
更新日期:2012-10-01 00:00:00
abstract::In a national US sample of pregnant women (n=311), we investigated the question of who becomes highly anxious about pregnancy by examining putative sociodemographic, pregnancy- and mental health-related predictors of pregnancy anxiety. We also assessed the contribution of pregnancy anxiety to the risk of significant a...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.07.010
更新日期:2013-04-01 00:00:00
abstract::People who engage in nonsuicidal self-injury (NSSI) often report high levels of impulsivity. However, results from behavioral tasks measuring impulsivity have been mixed: those with a history of NSSI generally perform comparably to healthy controls. Recent research suggests, however, that people who self-injure have s...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2016.10.011
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:It is well documented that patients with schizophrenia have impoverished quality of life (QOL). Efforts to determine the underpinnings of this impoverishment have implicated negative symptoms more than positive or disorganized symptoms. However, only a minority of individuals with the liability to schizophren...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.11.002
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Milder forms of depression are highly prevalent in the clinical setting as well as in primary care. However, it is still unclear whether there are distinguishable groups among the various subthreshold syndromes and to what extent they are associated with impairment, thus requiring treatment. Therefore, the s...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2005.04.007
更新日期:2006-01-01 00:00:00
abstract::The psychometric properties of the TCI-R method were investigated in a cohort of 15-year-old adolescents (n = 787). This is the lowest recommended age for using the adult version of the method. A factor analysis of the temperament and character scales was carried out on the basis of Principal Component Analysis with V...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2011.01.008
更新日期:2012-01-01 00:00:00
abstract::Separation anxiety disorder is well recognized as a juvenile psychiatric disorder, but it appears to be rarely diagnosed in adulthood. Drawing on our clinical impressions and a review of the relevant literature, we sought to investigate whether separation anxiety symptoms could be identified in adulthood. Forty-four s...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(97)90060-2
更新日期:1997-09-01 00:00:00
abstract::The relationship between personality and Delusional Disorder in still debated. The present study aimed to evaluate the role of personality features and emotional dispositions on the proneness to delusional beliefs, through the lens of a dimensional approach. 91 outpatients were administered the Structured Interview fo...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2018.07.002
更新日期:2018-08-01 00:00:00
abstract::Borderline personality disorder (BPD) is characterized by interpersonal disturbances, but the neurocognitive aspects of these symptoms are poorly understood. We hypothesized that patients with BPD have impaired perception of emotional expressions, which are related to symptoms of interpersonal dysfunction. To control ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2006.03.005
更新日期:2006-11-01 00:00:00
abstract::This article examines temporal relationships between negative emotions and pain in a cohort of 33 patients with chronic musculoskeletal pain enrolled in a telephone-based relapse prevention program (Therapeutic Interactive Voice Response [TIVR]), after 11 weeks of group cognitive behavioral therapy (CBT). Patients wer...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.11.008
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Despite the increasing recognition in clinical practice of body image problems in other than appearance related mental disorders, the question remains how aspects of body image are affected in different disorders. The aim of this study was to measure body image in patients with a variety of mental disorders a...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.01.004
更新日期:2017-04-01 00:00:00
abstract::Recent studies have suggested an association between childhood physical and sexual abuse and adult dissociative experiences. The purpose of this study was to determine the relationship of both childhood and adult-onset abuse and their characteristics for adult dissociative symptoms. One hundred forty-four psychiatric ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(96)90005-x
更新日期:1996-07-01 00:00:00
abstract::Until the 1850s, obsessive-compulsive phenomena were considered to be a variant of the old notion of insanity. Around this time they became a separate disease: first, as a member of the old class of the neuroses; then, briefly, as a variant of the newly formed notion of psychosis; and finally, as a neurosis proper (in...
journal_title:Comprehensive psychiatry
pub_type: 历史文章,杂志文章
doi:10.1016/0010-440x(89)90052-7
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVES:Poor treatment response is an important factor contributing to lack of treatment adherence. The goals of this research were to determine whether improvements in Positive and Negative Syndrome Scale (PANSS) symptom domains predict the likelihood of staying on treatment and whether differential responses to tr...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.12.003
更新日期:2012-01-01 00:00:00
abstract::The present study investigated the association of specific personality characteristics with agoraphobia, and whether they predicted long-term outcome following a group cognitive behavior therapy program. Thirty-three patients with agoraphobia with panic attacks, 18 with social phobia, and 26 "normals" were used in the...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(92)90038-r
更新日期:1992-09-01 00:00:00
abstract:INTRODUCTION:The Sewol ferry accident that occurred in April 2014 was one of the most tragic human-made disasters in Korean history. Due to the deaths of hundreds of children, bereaved families likely feel embittered; however, there is little extant research documenting embitterment among those who experienced the disa...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.12.007
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:We hypothesized that subjects with obsessive-compulsive disorder (OCD) who received extended-release fluvoxamine (fluvoxamine ER) in a 12-week placebo-controlled trial would exhibit improvements in psychosocial domains of health-related quality of life (HRQOL) and that additional improvements would occur afte...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.comppsych.2009.10.001
更新日期:2010-07-01 00:00:00
abstract::From a total sample of 1,448 psychiatric outpatients, 175 (12.1%) received a diagnosis of a somatoform disorder according to DSM-III-R criteria. One hundred twenty-two (70%) of these patients had another current axis I diagnosis, and this rate increased to 79% (139 of 175) when lifetime psychiatric diagnoses were reco...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(99)90131-1
更新日期:1999-07-01 00:00:00
abstract::Clinical experience suggests that bulimia nervosa is a disorder often accompanied by additional psychiatric symptoms. Based on unstructured clinical interviews, 21 additional Axis I and six Axis II diagnoses were assigned to a sample of 30 bulimic women. The Structured Clinic Interview for DSM-III-Patient Version (SCI...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(88)90066-1
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:We assess the convergent and predictive validity of the Defensive Functioning Scale (DFS) with measures of life events, including childhood abuse and adult partner victimization; dimensions of psychopathology, including axis I (depressive) and axis II (borderline personality disorder) symptoms; and quality of...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.06.003
更新日期:2011-03-01 00:00:00
abstract::The current status of subjective experiences in schizophrenia is examined. Subjective experiences are very frequent disorders in schizophrenic patients, and their study has been largely neglected. Recently, a number of scales that evaluate subjective experiences have been published, and although the psychometric prope...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/0010-440x(94)90192-9
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Insight into having a psychotic disorder is often considered to be a positive characteristic that improves quality of life. However, the evidence regarding this controversy is mixed. The present study examined the relation between insight and quality of life. METHOD:One hundred thirty-one participants with ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2005.08.006
更新日期:2006-07-01 00:00:00
abstract::The transition to alcohol dependence is supposed to occur during a critical period that begins with increased drinking and ends with a loss of control. This process may last about 3 to 4 years, and is modified by gender and accelerated by premorbid traits (e.g., novelty-seeking) and comorbid disorders (e.g., dissocial...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(00)80014-0
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:The present study aimed to determine the prevalence and associated factors of orgasmic dysfunction among Malay women with type 2 diabetes mellitus in Malaysia. METHODS:This cross-sectional study involved 347 women (174 non diabetic and 173 diabetic subjects) who attended the diabetic clinic in a university ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.03.009
更新日期:2014-01-01 00:00:00
abstract::Lack of insight of patients with schizophrenia into various aspects of their illness and treatment is an important clinical issue. Poor insight has been reported to be associated with neurocognitive deficits, particularly in the frontal and parietal functions. The aim of this study was to examine relationships between...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.11.002
更新日期:2005-07-01 00:00:00
abstract::Recent evidence suggests that a clinical form of separation anxiety can be observed in adults. An important question of relevance to defining the construct of adult separation anxiety is whether there is discontinuity between that constellation and other forms of anxiety. In the present study, 2 taxometric procedures ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2007.05.011
更新日期:2007-11-01 00:00:00