Transition to alcohol dependence: clinical and neurobiological considerations.

Abstract:

:The transition to alcohol dependence is supposed to occur during a critical period that begins with increased drinking and ends with a loss of control. This process may last about 3 to 4 years, and is modified by gender and accelerated by premorbid traits (e.g., novelty-seeking) and comorbid disorders (e.g., dissocial personality disorders according to ICD-10). Genetic disposition, environmental influences (e.g., stress), and sensitization by exposure are factors implicated in dependence that alter brain functions, some possibly in an irreversible way. Underlying neurobiological mechanisms that may have different time patterns are beginning to be characterized on a systemic, cellular, and molecular level. Repeated free choices of the rewarding compound seem to be necessary for the transition to dependence.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Schmidt LG,Dufeu P,Kuhn S,Smolka M,Rommelspacher H

doi

10.1016/s0010-440x(00)80014-0

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

90-4

issue

2 Suppl 1

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(00)80014-0

journal_volume

41

pub_type

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