Abstract：
BACKGROUND:Although reduced hippocampal volume (HCV) is a common finding in depression, it is unclear whether the structural alterations leading to reduction of HCV are pre-existing risk factors before the onset of clinical symptoms or a cumulative process that begins with the onset of clinical symptoms. The aim of the present study was to understand the anatomical status of the hippocampus prior to the clinical symptoms in subjects with high familial risk for depression. METHODS:Twenty-seven young women (mean age: 22.3 ± 2.1 years) who were at high risk for familial unipolar depression and 26 age- and gender-matched healthy controls (mean age: 22.1 ± 2.1 years) with low familial risk for depression were included in the study. Total hippocampal volumes were measured by manual tracing. For 3D shape differences, the spherical harmonic basis functions (SPHARM) software was used. The segmented images were parameterized, and the point-to-point based group difference was compared by the Hotelling's T-squared test with total brain volume and Beck Depression Scale as covariates. RESULTS:Although there was no difference in overall HCVs, shape analyses revealed a contracted area on the Cornu Ammonis (CA) 1 region of the right hippocampus head in the high-risk group compared to the low-risk group. Cross-sectional design and small sample size, including only females, were the main limitations of this study. CONCLUSION:This study with shape analyses provided data suggesting that local structural hippocampal alterations in the CA1 region might be associated with depression vulnerability in women at high risk.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Durmusoglu E,Ugurlu O,Akan S,Simsek F,Kizilates G,Kitis O,Ozkul BA,Eker C,Coburn KL,Gonul ASdoi
10.1016/j.comppsych.2018.01.004subject
Has Abstractpub_date
2018-04-01 00:00:00pages
7-13eissn
0010-440Xissn
1532-8384pii
S0010-440X(18)30010-5journal_volume
82pub_type
杂志文章abstract：BACKGROUND:Previous research has documented increased incidence of insecure attachment and theory of mind (ToM) deficits in individuals experiencing psychotic disorders. ToM has been theorized as a possible mediator of the relation between attachment and psychosis (Korver-Nieberg et al., 2014). The current study sought...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:This report studies the personality of individuals who suffer from dissociative trance disorder and examines whether the personality profiles could predict the individual's frequency of trance states. A total of 58 cases were given the Eysenck Personality Questionnaire (EPQ) and their personal information harvested fr...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1053/comp.2002.30808
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVES:The present study aimed to determine the prevalence and associated factors of orgasmic dysfunction among Malay women with type 2 diabetes mellitus in Malaysia. METHODS:This cross-sectional study involved 347 women (174 non diabetic and 173 diabetic subjects) who attended the diabetic clinic in a university ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2013.03.009
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Various factors contribute to suicide. Psychological strains are hypothesized to precede suicidal thought and attempt. Life satisfaction can be a measure of relative deprivation strain and aspiration-reality strain. AIMS:This study was to compare the suicide attempters with various levels of life satisfacti...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2016.12.002
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:The present study aims to provide a comprehensive profile of the primary family caregivers of schizophrenia individuals in rural China. METHOD:A cross-sectional study was conducted with a sample of 327 primary family caregivers of schizophrenia individuals recruited through a one-stage cluster sampling in Ni...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2018.04.002
更新日期：2018-07-01 00:00:00
abstract：:Childhood sexual abuse has been associated with adult dissociative symptomatology. The purpose of this study was to examine the relationship between specific characteristics of sexual abuse and dissociative experiences in adulthood. Fifty-six female inpatients with a history of physical abuse and severe sexual abuse r...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(94)90230-5
更新日期：1994-11-01 00:00:00
abstract：:Previous studies have shown that mindfulness meditation may improve well-being in healthy individuals and be effective in the treatment of mental and neurological disorders. Here, we investigated the effects of an 8-week mindfulness-mediation program on the personality profiles of three groups of healthy individuals w...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.03.009
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:This study compared a dimensional, trait domain approach to characterizing personality pathology with the traditional polythetic approach with respect to their associations with interpersonal functioning and personality traits from the five factor model. METHODS:Psychiatric inpatients (N=1476) were administ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.09.001
更新日期：2015-01-01 00:00:00
abstract：:We report the initial results from a prospective study designed to assess patients' functional outcome and level of service utilization following psychiatric hospitalization. All patients admitted between March 31, 1993 and April 1, 1994 were interviewed at admission and discharge, and 350 consenting patients were rea...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(96)90571-4
更新日期：1996-03-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0010-440x(99)90117-7
更新日期：1999-03-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.comppsych.2010.04.007
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:The human brain presents ongoing temporal fluctuations whose dynamic range indicates the capacity of information processing and can be approximately quantified with entropy. Using functional magnetic resonance imaging (fMRI), recent studies have shown a stable distribution pattern of temporal brain entropy (...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2018.11.015
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Family history of suicidal behavior and suicide are both risk factors for suicide. However, the effects of family history of suicide versus suicide attempts on patient suicidal behavior remain unclear. The aim of the present study was to understand if family history of suicide as compared to family history o...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2016.06.006
更新日期：2016-10-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0010-440x(89)90083-7
更新日期：1989-11-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1053/comp.2001.23144
更新日期：2001-05-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0010-440x(90)90055-w
更新日期：1990-01-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2006.03.005
更新日期：2006-11-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2013.12.013
更新日期：2014-05-01 00:00:00
abstract：:The relationship between personality and Delusional Disorder in still debated. The present study aimed to evaluate the role of personality features and emotional dispositions on the proneness to delusional beliefs, through the lens of a dimensional approach. 91 outpatients were administered the Structured Interview fo...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2018.07.002
更新日期：2018-08-01 00:00:00
abstract：:The covariation patterns of DSM-IV personality disorders (PDs) were studied in 431 consecutively admitted psychiatric patients. The co-occurrence rate was greater than 50% for all DSM-IV PDs. Both bivariate association tests and loglinear models showed distinct significant covariation patterns among PDs which were sta...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/S0010-440X(00)90049-X
更新日期：2000-05-01 00:00:00
abstract：:In this study, the conceptual validity of the unified model of personality, postulated by Cloninger (1987) and measured by the Tridimensional Personality Questionnaire (TPQ), is tested in diverse Yugoslav and American societies. The issue of cross-cultural sensitivity of personality studies and the methodology that mi...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(91)90040-j
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abstract：:A second case of anorexia nervosa associated with Klinefelter's syndrome is described. Gender identity problems were thought to have been significant in this adolescent. ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(91)90079-r
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.06.010
更新日期：2014-11-01 00:00:00
abstract：:Based on a representative sample of elderly subjects, a description of the limitations in activities of daily living (ADL) and instrumental ADL (IADL) at subthreshold levels of dementia and depression is presented and compared against a sample of psychiatric non-cases and samples with specified levels of the respectiv...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(00)80004-8
更新日期：2000-03-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章,评审
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更新日期：1994-05-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(90)90009-h
更新日期：1990-05-01 00:00:00
abstract：AIMS:This study was designed to evaluate the relationship between insight and the severity of psychotic symptomatology in a sample of patients in an acute phase of psychosis, as well as to analyze the relationship between insight and the symptomatic profile of the patient. In addition, the role of general cognitive abi...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2011.08.008
更新日期：2012-07-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2016.06.005
更新日期：2016-08-01 00:00:00
abstract：:The distribution of schizophrenic subtypes shows a high range of cross-cultural and historical variations. Our study aimed to investigate the effect of different diagnostic criteria on the prevalence of schizophrenic subtypes. A sample of 220 consecutively admitted schizophrenic patients from 3 different psychiatric i...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1016/j.comppsych.2005.03.003
更新日期：2005-11-01 00:00:00
abstract：:Age-specific suicide rates in the United States between 1951 and 1988 were shown in cohort, cross-sectional, and age group formats. Despite considerable variation among women and younger and older men, suicide rates among 40- to 44-year-old men have remained stable. Since suicide is strongly influenced by psychosocial...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(96)90039-5
更新日期：1996-05-01 00:00:00
