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Extended-release fluvoxamine and improvements in quality of life in patients with obsessive-compulsive disorder.

Abstract：

OBJECTIVE:We hypothesized that subjects with obsessive-compulsive disorder (OCD) who received extended-release fluvoxamine (fluvoxamine ER) in a 12-week placebo-controlled trial would exhibit improvements in psychosocial domains of health-related quality of life (HRQOL) and that additional improvements would occur after a 40-week open-label extension trial. We also hypothesized that greater OCD symptom improvement in the first 12 weeks of treatment would be associated with greater HRQOL improvement after 52 weeks of treatment. METHODS:In the 12-week placebo-controlled trial, subjects were randomized to receive placebo or 100 mg/d of fluvoxamine ER and then titrated in weekly 50 mg increments to a final dose of 100 to 300 mg/d. All subjects enrolled in the 40-week extension trial followed a similar titration, during which they were maintained on their highest well-tolerated dose. RESULTS:After 12 weeks of treatment, fluvoxamine ER subjects experienced significantly greater decreases than placebo subjects in Yale-Brown Obsessive-Compulsive Scale scores (P = .001). Both the active drug and placebo groups exhibited significant improvements in psychosocial domains of HRQOL; further improvement occurred after 40 weeks of open-label treatment with active drug. The greater the improvement in OCD severity at 12 weeks, the greater the improvement at 52 weeks in the psychosocial domains (Social Functioning r = -0.39, P = .027; Emotional Problems r = -0.37, P = .037; Mental Health r = -0.49, P = .004). CONCLUSION:Improvement in Yale-Brown Obsessive-Compulsive Scale severity scores during treatment with fluvoxamine ER was associated with improvements in psychosocial aspects of HRQOL that increased over an extended period of treatment.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Koran LM,Bromberg D,Hornfeldt CS,Shepski JC,Wang S,Hollander E

doi

10.1016/j.comppsych.2009.10.001

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

373-9

issue

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(09)00125-4

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Extended-release fluvoxamine and improvements in quality of life in patients with obsessive-compulsive disorder.