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Quality of life in bipolar and schizoaffective disorder--a naturalistic approach.

Abstract：

PURPOSE:The aim of this study was to evaluate the health-related quality of life (HRQoL) in bipolar type I (BD I) and schizoaffective (SQA) patients during a 2-year period in a naturalistic study. METHODS:This study was based on the data generated by the Bipolar Comprehensive Outcome Study, a prospective, non-interventional, observational study of participants with BD I and SQA disorder. Mixed-Model Repeated Measures Analysis was used to analyze changes in the SF-36 and EQ-5D. RESULTS:Participants exhibited low health status at baseline with SF-36 mean scores of 46.7±10.5 and 36.9±12.9 (best imaginable health=100, normal population≈50) for physical and mental components, respectively. No significant differences were found between the ratings of the BD I and SQA patients on HRQoL. The SF-36 SMC improved significantly over 24 months although SPC scores remained consistent across the study. On the whole, the lowest SMC score was observed among the depressed patients (38.20), followed by the patients with a mixed state (39.01) and the manic patients (39.83). LIMITATIONS:The observational design may have limited the causal relationships and the generalizability within the current findings. CONCLUSIONS:HRQoL was significantly impaired in all stages of BD and SQA when compared to the general population. The impairment of HRQoL was most pronounced in the depressed state, followed by the mixed state and then the manic state. The euthymic patients showed the least impairment. In addition, patients showed a global improvement in their mental health satisfaction over the 2 years follow up period.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Martín-Subero M,Berk L,Dodd S,Kamalesh V,Maes M,Kulkarni J,De Castella A,Fitzgerald PB,Berk M

doi

10.1016/j.comppsych.2014.05.009

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1540-5

issue

7

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(14)00127-8

journal_volume

55

pub_type

杂志文章

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