The etiology of schizophrenia and the origin of language: overview of a theory.

Abstract:

:Schizophrenia is present in all human populations with approximately the same incidence. Why does such illness persist given that it is associated with a reproductive disadvantage? What is the balancing advantage? A possible explanation is linked to human language. According to this hypothesis schizophrenia occurs as a manifestation of genetic diversity associated with language--the function by which Homo sapiens has separated from other primate species. Language originated by a genetic mutation that allowed the cerebral hemispheres to develop with a degree of specialization (or lateralization) reflected in cerebral asymmetries. Individuals with schizophrenia show lesser structural and functional brain asymmetries than the population as a whole, and this finding can be interpreted as a delay, or failure in, establishing hemispheric dominance for language. We review recent evidence supporting this theory.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Berlim MT,Mattevi BS,Belmonte-de-Abreu P,Crow TJ

doi

10.1053/comp.2003.50003

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

7-14

issue

1

eissn

0010-440X

issn

1532-8384

pii

S0010440X03000233

journal_volume

44

pub_type

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