Abstract:
OBJECTIVE:There is a lack of data about residual symptoms in Chinese patients with depression. The aim of this study was to evaluate the association of residual symptoms with social functional impairment in these patients. METHODS:This was a multicenter cross-sectional study conducted in 11 hospitals in eight cities of China from September 2014 to April 2015. Residual symptoms and social functioning were assessed using the SDS, QIDS-SR16, Q-LES-Q-SF, and PHQ-15 scales. Logistic regression analysis was used to determine the factors associated with social functional impairment. RESULTS:Among the 1503 patients, 915 (60.9%) had no functional impairment (SDS ≤6) and 588 (39.1%) showed functional impairment (SDS >6). Those with impairment had higher PHQ-15 scores (7.4 ± 4.8 vs. 4.0 ± 3.4, P < 0.0001), lower Q-LES-Q-SF scores (all items P < 0.0001), higher SDS scores (13.9 ± 5.7 vs. 2.8 ± 2.2, P < 0.0001), and higher scores for all QIDS dimensions (all P < .0001). The factors related to functional impairment included QIDS dimension 7 (loss of interest) (OR = 2.137, 95%CI 1.600-2.853, P < 0.0001), QIDS dimension 9 (mental anxiety) (OR = 1.627, 95%CI 1.215-2.180, P = 0.0011), QIDS dimension 3 (appetite) (OR = 1.502, 95%CI 1.141-1.977, P = 0.0037), QIDS dimension 8 (energy) (OR = 1.468, 95%CI 1.092-1.973, P = 0.0110), age (OR = 0.982, 95%CI 0.971-0.993, P = 0.0013), disease course (OR = -1.004, 95%CI 1.002-1.006, P = 0.0004), and QIDS dimension 1 (sleep disorders) (OR = 1.622, 95%CI 1.068-2.463, P = 0.0232). CONCLUSION:Compared with patients with normal social function, cases with impaired social function have more physical symptoms, more residual symptoms of depression, and less satisfaction with the quality of life. Residual symptoms are associated with social functional impairment in patients with depression.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Wang Y,Wang G,Zhang N,Huang J,Wu W,Jia F,Liu T,Gao C,Hu J,Hong W,Fang Ydoi
10.1016/j.comppsych.2020.152164subject
Has Abstractpub_date
2020-01-22 00:00:00pages
152164eissn
0010-440Xissn
1532-8384pii
S0010-440X(20)30006-7journal_volume
98pub_type
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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