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Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients.

Abstract：

BACKGROUND:OCD causes impairment in different areas of the patients' quality of life (QoL), such as sociability, family relationships, and occupational performance. The literature has emphasized the relevance of assessing QoL as a critical outcome in mental health studies. AIMS:The aim of this study was to investigate sociodemographic and clinical predictors of QoL, including treatment response, in a large sample of OCD subjects. PROCEDURES:575 adult OCD outpatients were interviewed as part of the Brazilian OCD Consortium (CTOC). A smaller number of subjects (N = 143) participated on a clinical trial conducted by one of the CTOC sites. RESULTS:OCD patients were more impaired in their QoL when compared to the Brazilian normative data. Obsessive-compulsive symptoms (OCS) severity had significant correlations with all Medical Outcome Short-Form questionnaire (SF-36) domains. Different OCS dimensions had specific correlations with each SF-36 domain. OCS, depression and anxiety severity significantly increased the impairment risk for the SF-36 domains. Suicidality increased the relative risks for impairment in the Role-Functioning and the Vitality domains by 51% and 17%, respectively. There was a significant improvement in some SF-36 dimensions after treatment. CONCLUSIONS:QoL domains are highly compromised in OCD patients. Each SF-36 domain had distinct associations with sociodemographic and clinical variables, including OCS dimensions, suicidality and treatment response. These findings emphasize the OCD heterogeneity and the need for including QoL assessment in clinical practice and research studies.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Velloso P,Piccinato C,Ferrão Y,Perin EA,Cesar R,Fontenelle LF,Hounie AG,do Rosário MC

doi

10.1016/j.comppsych.2018.07.007

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

82-90

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(18)30121-4

journal_volume

86

pub_type

杂志文章

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