Abstract：
BACKGROUND:Medical illnesses are highly comorbid with bipolar disorder, but their relationship to illness characteristics has not been previously delineated. METHODS:The incidence of 34 medical conditions and 6 poor prognosis factors (PPFs) was derived from answers to a questionnaire in over 900 outpatients with bipolar disorder who gave informed consent. The relationship of PPFs to the number of medical comorbidities was examined by Mann-Whitney U, Pearson r, and logistic regression. RESULTS:When examined individually, each of the 6 PPFs associated with an adverse course of bipolar disorder was significantly related to the number of medical comorbidities patients had. When age, gender, and independence of their relationships to each other were controlled for via regression, 3 of the PPFs remained significant (anxiety disorder, childhood abuse, and age of onset), and having 20 or more prior episodes was a strong trend. The number of PPFs was correlated with the number of comorbidities, although the above 3 PPFs show a similar magnitude of relationship. CONCLUSION:A history of childhood adversity, early age of onset of bipolar disorder, and an anxiety comorbidity were independently related to the number of medical comorbidities that patients experienced as adults. While the nature and mechanisms of this linkage remain to be further explored, the findings indicate the need for greater attention to and treatment of these 3 PPFs in hopes of ameliorating both the adverse course of bipolar illness and the burden of medical comorbidities with which they are associated.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Post RM,Altshuler L,Leverich GS,Frye MA,Suppes T,McElroy SL,Keck PE Jr,Nolen WA,Kupka RW,Grunze H,Rowe Mdoi
10.1016/j.comppsych.2014.08.050subject
Has Abstractpub_date
2015-01-01 00:00:00pages
21-8eissn
0010-440Xissn
1532-8384pii
S0010-440X(14)00242-9journal_volume
56pub_type
杂志文章abstract：:The question of what role genetic factors have in the transmission of suicidal behavior, in particular suicide itself, is discussed on the basis of five studies of an epidemiologically clearly defined region (the Province of Salzburg, Austria). The high percentage of suicide-positive family histories as compared with ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(90)90070-9
更新日期：1990-11-01 00:00:00
abstract：OBJECTIVE:This study sought to determine the trauma-related psychiatric comorbidity of somatization disorder among women who applied to an outpatient psychiatric unit of a general hospital in eastern Turkey. METHODS:Forty women with somatization disorder and 40 non-clinical controls recruited from the same geographic ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.08.052
更新日期：2014-11-01 00:00:00
abstract：:Twenty-four of 52 (46%) schizophrenic patients hospitalized because of acute psychotic episodes associated with preadmission medication noncompliance required involuntary commitment. Committed patients were rated as significantly more severely ill than voluntary patients and were significantly more likely to be transf...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(89)90113-2
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:A single-item assessment of sad mood after remission from MDD is predictive of relapse, yet the mechanisms that play a role in depressive relapse remain poorly understood. METHODS:In 283 patients, remitted from recurrent depression (DSM-IV-TR criteria; HAM-D17 score ≤ 10), we examined emotional scarring, th...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2015.02.010
更新日期：2015-05-01 00:00:00
abstract：:Co-occurring substance abuse is common among people with chronic mental illnesses such as schizophrenia. Although gender differences have been established among substance abusers in the general population and among people with schizophrenia, little is known about gender differences in people with the dual disorders of...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(97)90090-0
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Patients with obsessive compulsive disorder (OCD) have inferior social functioning compared to healthy controls, but the exact nature of these social deficits, and the underpinning mechanisms, are unknown. We sought to investigate social functioning in patients with OCD by measuring their involuntary/spontane...
journal_title：Comprehensive psychiatry
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doi：10.1016/j.comppsych.2013.08.007
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:There are problems with the fatigue measures currently used in depressed patients. The Multidimensional Fatigue Inventory (MFI-20) covering general fatigue, physical fatigue, mental fatigue, reduced activity and reduced motivation has been widely used in patients with cancer and chronic fatigue syndrome. To ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.06.006
更新日期：2014-10-01 00:00:00
abstract：:Borderline personality disorder (BPD) is characterized by interpersonal disturbances, but the neurocognitive aspects of these symptoms are poorly understood. We hypothesized that patients with BPD have impaired perception of emotional expressions, which are related to symptoms of interpersonal dysfunction. To control ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2006.03.005
更新日期：2006-11-01 00:00:00
abstract：:This study employed grade of membership (GoM) analysis in a clinical setting to determine if the DSM-III-R personality disorder (PD) diagnostic criteria cluster into recognizable disorders resembling the official axis II nosology. The GoM model, based on fuzzy-set theoretic concepts, explicitly examines medical diagno...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(99)90079-2
更新日期：1999-01-01 00:00:00
abstract：:Despite the seriousness of acute medical and psychological consequences of cocaine abuse, little knowledge exists about the chronic effects of the drug. Investigation of a sample of abstinent freebase (crack) abusers in the Bahamas provides the first research evidence that prolonged cocaine abuse may result in persist...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/0010-440x(90)90045-t
更新日期：1990-07-01 00:00:00
abstract：:The present study sought to determine concordance of cognitive impairment among elderly female twins. Cognitive testing was performed by telephone interview in a sample of 100 female-female twins older than 65 years. The participants were 32 monozygotic (MZ) and 18 dizygotic (DZ) female twin pairs, all between the age...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1053/comp.2003.50019
更新日期：2003-03-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/S0010-440X(03)00010-5
更新日期：2003-05-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.04.025
更新日期：2014-08-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(96)90005-x
更新日期：1996-07-01 00:00:00
abstract：:Insight is a quality which has been highly valued by most clinicians in the mental health field, largely because a strong link is assumed between good insight and better quality of life. Yet it is a complex construct, one which has not until recently been subjected to much critical scrutiny or adequately explicated. A...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0010-440x(99)90117-7
更新日期：1999-03-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1053/comp.2000.9012
更新日期：2000-09-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2010.10.016
更新日期：2011-11-01 00:00:00
abstract：:The Davidson Trauma Scale (DTS) is a validated self-rating scale used in the diagnosis of post-traumatic stress disorder (PTSD). A shorter version of the DTS was developed to serve as a diagnostic screening tool. A four-item scale, the SPAN (named for its principal four items: Startle, Physiological arousal, Anger, an...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1053/comp.2003.50013
更新日期：2003-01-01 00:00:00
abstract：:We have reported elsewhere the development of a brief version of the Parental Bonding Instrument (PBI), which we have called the Parental Bonding Instrument-Brief Current form (PBI-BC), for use in survey research in adolescent samples. It was shown in that report that PBI-BC retained the factor structure of the origin...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
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更新日期：1992-11-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2014.09.012
更新日期：2015-01-01 00:00:00
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journal_title：Comprehensive psychiatry
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journal_title：Comprehensive psychiatry
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doi：10.1016/0010-440x(89)90003-5
更新日期：1989-09-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(99)90092-5
更新日期：1999-11-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2016.06.006
更新日期：2016-10-01 00:00:00
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journal_title：Comprehensive psychiatry
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更新日期：2003-07-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2020.152164
更新日期：2020-01-22 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(98)90067-0
更新日期：1998-07-01 00:00:00
abstract：:From a total sample of 1,448 psychiatric outpatients, 175 (12.1%) received a diagnosis of a somatoform disorder according to DSM-III-R criteria. One hundred twenty-two (70%) of these patients had another current axis I diagnosis, and this rate increased to 79% (139 of 175) when lifetime psychiatric diagnoses were reco...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/s0010-440x(99)90131-1
更新日期：1999-07-01 00:00:00
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journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2018.04.002
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:Millions of children were exposed to major earthquake in China, with serious psychological and developmental consequences. To obtain accurate rate of post-disaster related disorder and identify predictors may help inform post-disaster rescue and rehabilitation efforts. The present longitudinal study explored ...
journal_title：Comprehensive psychiatry
pub_type： 杂志文章
doi：10.1016/j.comppsych.2016.09.004
更新日期：2017-01-01 00:00:00
