A preliminary report on pain thresholds in bulimia nervosa during a bulimic episode.

Abstract:

:Subjects with bulimia nervosa (BN) have been shown to exhibit abnormal satiety responses. Short-term satiety is largely mediated by afferent vagal activity. Activation of afferent vagal fibers has also been found to stimulate a descending pain inhibitory pathway that leads to elevation in somatosensory pain thresholds. Therefore, the study of pain thresholds in BN subjects may lead to a better understanding of afferent vagal function in this disorder. In this preliminary study, pressure pain thresholds were assessed in nine subjects with BN on 3 consecutive days during a binge-eating and vomiting (B/V) episode, during a normal meal, and after an overnight fast. A significant time versus condition effect was found with a significant change in the pain threshold in BN subjects under the B/V condition only. These data are consistent with the hypothesis that vagal afferent activation by a B/V episode also activates the descending pain inhibitory pathway.

journal_name

Compr Psychiatry

journal_title

Comprehensive psychiatry

authors

Raymond NC,Eckert ED,Hamalainen M,Evanson D,Thuras PD,Hartman BK,Faris PL

doi

10.1016/s0010-440x(99)90009-3

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

229-33

issue

3

eissn

0010-440X

issn

1532-8384

pii

S0010-440X(99)90009-3

journal_volume

40

pub_type

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