Abstract:
BACKGROUND:Compared to other mental illnesses, bipolar disorder is associated with a disproportionately high rate of substance use disorders (SUDs), and the co-occurrence is associated with significant morbidity and mortality. Early diagnosis of primary bipolar disorder may provide opportunities for SUD prevention, but little is known about the risk factors for secondary SUD among individuals with bipolar disorder. The purposes of this study were to describe the population of people with childhood and adolescent-onset primary bipolar disorder, and to identify risk factors for secondary SUD in this population. METHODS:Using data collected from the National Comorbidity Survey Replication study, we identified 158 individuals with childhood-onset (<13 years) or adolescent-onset (13-18 years) primary bipolar disorder (I, II or subthreshold). Survival analysis was used to identify risk factors for SUD. RESULTS:Compared to adolescent-onset, people with childhood-onset bipolar disorder had increased likelihoods of attention deficit hyperactivity disorder (ADHD) (adjusted odds ratio=2.81) and suicide attempt (aOR=3.61). Males were more likely than females to develop SUD, and did so at a faster rate. Hazard ratios of risk factors for SUD were: lifetime oppositional defiant disorder (2.048), any lifetime anxiety disorder (3.077), adolescent-onset bipolar disorder (1.653), and suicide attempt (15.424). SUD was not predicted by bipolar disorder type, family history of bipolar disorder, hospitalization for a mood episode, ADHD or conduct disorder. CONCLUSIONS:As clinicians struggle to help individuals with bipolar disorder, this study provides information that might be useful in identifying individuals at higher risk for SUD. Future research can examine whether targeting these risk factors may help prevent secondary SUD.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Kenneson A,Funderburk JS,Maisto SAdoi
10.1016/j.comppsych.2012.12.008subject
Has Abstractpub_date
2013-07-01 00:00:00pages
439-46issue
5eissn
0010-440Xissn
1532-8384pii
S0010-440X(12)00264-7journal_volume
54pub_type
杂志文章abstract:OBJECTIVE:To examine attachment and affective temperament in patients who have been diagnosed with Bipolar Disorder and to investigate possible differences in both variables among Bipolar I Disorder (BD-I), Bipolar II Disorder (BD-II), and cyclothymic patients. METHODS:Ninety (45 male and 45 female) outpatients with b...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.12.006
更新日期:2014-05-01 00:00:00
abstract::The aim of the present study was to examine cognitive performance and basic symptoms (BS) in the relatives of schizophrenic patients. The experimental sample comprised 24 first-degree relatives of patients. Each relative was matched to one control. Cognitive tests were: Continuous Performance Test (CPT), N-Back Workin...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.comppsych.2008.01.001
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Kleptomania is characterized by repetitive stealing and has severe consequences for patients. Stigma, a lack of standardized therapy and a limited number of assessment tools hinder advances in treatment. This study provides preliminary data on the Portuguese-language version of the Kleptomania Symptom Assess...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.09.013
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:This study aimed to describe, compare, and predict mental health outcomes of different migrant groups and native residents in Switzerland. SUBJECTS AND METHODS:Asylum seekers (n=65); refugees holding permanent protection visas (n=34); illegal migrants (n=21); labor migrants (n=26); and residents (n=56) complet...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.02.003
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Although research on body dysmorphic disorder (BDD) is increasing, no follow-up studies of this disorder's course of illness have been published. METHODS:The status of 95 outpatients with BDD treated in a clinical practice was assessed by chart review. Standard scales were used to rate subjects at baseline ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.12.001
更新日期:2005-09-01 00:00:00
abstract::Cloninger's psychobiological model of temperament and character postulates that each of the temperament dimensions is associated with a specific emotional experience, depending on the situational cues. The aim of the present study was to test this postulate in a variety of challenging experimental tasks. The participa...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.07.023
更新日期:2005-03-01 00:00:00
abstract::This study investigated relevant outcome domains in the patient's perspective following psychiatric outpatient treatment for non-psychotic, non-substance-related disorders. Questionnaires, including the Client Satisfaction Questionnaire (CSQ) and the Bern Inventory of Treatment Goals (BIT-C) applied as a broad typolog...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.02.001
更新日期:2004-05-01 00:00:00
abstract::Investigation of relationship patterns between co-occurring symptoms has greatly improved the efficacy of psychiatric care. Depression and anxiety often present together, and identification of primary vs secondary psychiatric symptoms has implications for treatment. Previous psychotherapy research investigating the re...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.comppsych.2008.06.009
更新日期:2009-03-01 00:00:00
abstract::The goal of this study is to replicate an earlier epidemiological finding of seasonal changes in mood and behavior among Chinese medical students using an independent study population. Three hundred nineteen college students were surveyed with a Chinese version of the Seasonal Pattern Assessment Questionnaire (SPAQ) a...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(00)90132-9
更新日期:2000-01-01 00:00:00
abstract::Patients who meet DSM-III-R criteria for a diagnosis of panic disorder often show a complex mixture of psychopathological symptoms, including panic attacks (spontaneous and situational), anxiety (anticipatory and generalized), phobias (fear and avoidance), depression/dysphoria, and social and occupational disability. ...
journal_title:Comprehensive psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0010-440x(91)90003-u
更新日期:1991-03-01 00:00:00
abstract::The impact of concurrent axis I diagnoses and axis II traits on the efficacy of a 22-session exposure-based treatment program for 43 outpatients with panic disorder and agoraphobia (PDA) and 63 with obsessive-compulsive disorder (OCD) was examined. Trained interviewers used the Structured Clinical Interview for DSM-II...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1053/comp.2001.19746
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Most research on the assessment and characteristics of prolonged grief disorder (PGD) has been conducted in Western bereaved samples. Limited information about PGD in Chinese samples exists. This study aims to validate the Chinese version of the Inventory of Complicated grief (ICG), examine the distinctivene...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2015.12.001
更新日期:2016-04-01 00:00:00
abstract::Although several studies have addressed the issue of the relationship between the subjective response to neuroleptics and drug compliance, very little attention has been given to the study of the subjective experience of psychosis and drug attitudes. The present study was therefore undertaken to examine the relationsh...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1053/comp.2000.16566
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Insight into having a psychotic disorder is often considered to be a positive characteristic that improves quality of life. However, the evidence regarding this controversy is mixed. The present study examined the relation between insight and quality of life. METHOD:One hundred thirty-one participants with ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2005.08.006
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:This study compared a dimensional, trait domain approach to characterizing personality pathology with the traditional polythetic approach with respect to their associations with interpersonal functioning and personality traits from the five factor model. METHODS:Psychiatric inpatients (N=1476) were administ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.09.001
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Timely administration/supplementation of a specific serotonin reuptake inhibitor with a second therapeutic agent could improve treatment outcome in patients with major depressive disorder (MDD). The purpose of this study was to identify the optimal time at which to implement supplementation so as to maximize...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.comppsych.2010.04.007
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Although it is well-established that juvenile offenders are at an elevated risk for depression and that, within this group, females have the highest risk, little is known regarding the trends in the prevalence of depression among juvenile offenders in the United States. In the present study, we systematically e...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.09.005
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to develop and test the Talbieh Brief Distress Inventory (TBDI), a 24-item self-report questionnaire that measures psychological distress among immigrants. The TBDI combines items from the Brief Symptom Inventory (BSI) and the Psychiatric Epidemiology Research Interview Demoralization Sca...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(95)90253-8
更新日期:1995-11-01 00:00:00
abstract::This study investigated several aspects of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder (APD) construct, with emphasis on the psychometric properties of the diagnostic criteria and the prototype nature of the construct. A sample of 1,058 patien...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.comppsych.2006.01.006
更新日期:2006-09-01 00:00:00
abstract::Lack of insight of patients with schizophrenia into various aspects of their illness and treatment is an important clinical issue. Poor insight has been reported to be associated with neurocognitive deficits, particularly in the frontal and parietal functions. The aim of this study was to examine relationships between...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.11.002
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:We hypothesized that subjects with obsessive-compulsive disorder (OCD) who received extended-release fluvoxamine (fluvoxamine ER) in a 12-week placebo-controlled trial would exhibit improvements in psychosocial domains of health-related quality of life (HRQOL) and that additional improvements would occur afte...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.comppsych.2009.10.001
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:Coercive and disruptive behaviors (CDBs) are commonplace in pediatric obsessive-compulsive disorder (OCD) and are associated with increased disorder impact and reduced treatment response. Prior research suggests that CDBs mediate the cross-sectional relationship between family accommodation and OCD symptom seve...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2018.07.012
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Medical illnesses are highly comorbid with bipolar disorder, but their relationship to illness characteristics has not been previously delineated. METHODS:The incidence of 34 medical conditions and 6 poor prognosis factors (PPFs) was derived from answers to a questionnaire in over 900 outpatients with bipol...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.08.050
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The present study aimed to determine the prevalence and associated factors of orgasmic dysfunction among Malay women with type 2 diabetes mellitus in Malaysia. METHODS:This cross-sectional study involved 347 women (174 non diabetic and 173 diabetic subjects) who attended the diabetic clinic in a university ...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2013.03.009
更新日期:2014-01-01 00:00:00
abstract::More than a decade ago, a consensus panel recommended that remission be defined on the 17-item version of the Hamilton Rating Scale for Depression (HAM-D) as a cutoff of less than 7. Recently, some investigators have suggested that this threshold to define remission may be too high. If true, this means that heterogene...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2006.10.005
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Alcohol abuse and dependence are frequently associated with psychiatric disorders and personality disorders (PDs) with differences among gender. However, only few studies investigated gender differences in PDs among alcoholics. The aim of this study was to investigate PDs in a sample of patients accessing in...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2011.05.011
更新日期:2012-05-01 00:00:00
abstract::The mental and physical health care issues of medical students are increasingly recognized as both prevalent and complex. Emotional distress, symptoms of mental illness, and maladaptive substance use are widespread and may often be driven by training-related stressors. The data suggest that nearly all medical students...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1053/comp.2000.0410303
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:It is well documented that patients with schizophrenia have impoverished quality of life (QOL). Efforts to determine the underpinnings of this impoverishment have implicated negative symptoms more than positive or disorganized symptoms. However, only a minority of individuals with the liability to schizophren...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.11.002
更新日期:2009-09-01 00:00:00
abstract::Dimensional approaches to psychiatric disorders have shown an increased relevance in the ongoing debate for the forthcoming Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In line with previously validated instruments for the assessment of different mood, anxiety, eating and psychotic spectra, we...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2008.11.006
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:Poor treatment response is an important factor contributing to lack of treatment adherence. The goals of this research were to determine whether improvements in Positive and Negative Syndrome Scale (PANSS) symptom domains predict the likelihood of staying on treatment and whether differential responses to tr...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.12.003
更新日期:2012-01-01 00:00:00