Abstract:
INTRODUCTION:Dopamine receptor polymorphisms have been associated with specific patterns of novelty seeking (NS) temperamental nature and frontal executive function. In addition, carriers of dopamine receptor type 2 (DRD2)-TaqI A1 have been hypothesized to be potentially vulnerable to addictive behaviors. In the present study, the association between dopamine D2 polymorphisms, NS, and frontal executive function was studied. METHODS:Thirty-seven methamphetamine (MA)-dependent subjects and 40 healthy comparison subjects participated in the current study. The severity of addiction, NS temperament, and frontal executive functions were measured using the Addiction Severity Index, the NS subscale in the Temperament and Character Inventory, and the Wisconsin Card Sorting Test, respectively. All subjects were genotyped with regard to DRD2-TaqI polymorphisms. RESULTS:The prevalence of DRD2-TaqI A1 allele polymorphisms was greater in the MA-abuser group than in the comparison group. Patients with MA dependence also had higher NS characteristics and high scores in total trials, errors, and perseverative errors of the Wisconsin Card Sorting Test than comparison subjects. Within patients with MA dependence, the subgroup of DRD2-TaqI A1 carrier had greater NS scores relative to those without, whereas there was only a trend level of lower frontal executive function in the first subgroup. CONCLUSION:In the present study, the MA-dependent patients with DRD2-TaqI A1 allele had significantly greater NS scores and lower frontal executive function with a trend level than those without. These preliminary results suggest that MA-dependent patients may have the possibility of genetic and biogenic vulnerability to MA.
journal_name
Compr Psychiatryjournal_title
Comprehensive psychiatryauthors
Han DH,Yoon SJ,Sung YH,Lee YS,Kee BS,Lyoo IK,Renshaw PF,Cho SCdoi
10.1016/j.comppsych.2008.01.008subject
Has Abstractpub_date
2008-07-01 00:00:00pages
387-92issue
4eissn
0010-440Xissn
1532-8384pii
S0010-440X(08)00028-Xjournal_volume
49pub_type
杂志文章abstract::It has been hypothesized that college women are particularly susceptible to the development and maintenance of disturbed eating behaviors. The purpose of this study was to determine the frequency of disordered eating attitudes and eating disorders in a sample of Turkish female college students. The Eating Attitudes Te...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2005.05.004
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abstract:BACKGROUND:Whilst impulsivity is most commonly linked to the development of internalizing disorders, high levels of impulsivity, anxiety, and depression have been found in detained juvenile offenders. We therefore sought to determine whether impulsivity is associated with the development of self-reported anxiety or dep...
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2016.06.006
更新日期:2016-10-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0010-440x(91)90003-u
更新日期:1991-03-01 00:00:00
abstract::The aim of this study was to examine the role of emotions like pity and anger in mediating the relationship between beliefs about the controllability of a mental illness, and the willingness to help someone with a mental illness. In particular, we tested the hypothesis that the effects of beliefs about controllability...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2015.12.009
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/s0010-440x(00)90132-9
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journal_title:Comprehensive psychiatry
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journal_title:Comprehensive psychiatry
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doi:10.1016/j.comppsych.2013.03.011
更新日期:2014-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(92)90059-y
更新日期:1992-11-01 00:00:00
abstract::The distribution of schizophrenic subtypes shows a high range of cross-cultural and historical variations. Our study aimed to investigate the effect of different diagnostic criteria on the prevalence of schizophrenic subtypes. A sample of 220 consecutively admitted schizophrenic patients from 3 different psychiatric i...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.comppsych.2005.03.003
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:A new diagnostic category called Hoarding Disorder (HD) has been proposed for inclusion in DSM-5. It is paramount that this addition does not result in an over-pathologization of normative behavior. Collectors constitute a valid population within which to test the diagnostic boundaries of HD. The current stud...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2012.07.063
更新日期:2013-04-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2017.09.007
更新日期:2018-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(94)90016-7
更新日期:1994-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2009.09.005
更新日期:2010-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0010-440x(98)90057-8
更新日期:1998-07-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.comppsych.2013.01.005
更新日期:2014-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
abstract::The rates of comorbid personality disorders in patients with panic disorder are reported to be elevated, have an adverse impact on the response to treatment, and increase the likelihood of relapse on treatment discontinuation. We examined the rates of personality disorders in panic disorder patients in a longitudinal,...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/0010-440x(94)90278-x
更新日期:1994-09-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2004.07.012
更新日期:2004-11-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2014.08.050
更新日期:2015-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2006.05.005
更新日期:2007-01-01 00:00:00
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journal_title:Comprehensive psychiatry
pub_type: 杂志文章
doi:10.1016/j.comppsych.2010.06.003
更新日期:2011-03-01 00:00:00
abstract::The aim of the present study was to examine cognitive performance and basic symptoms (BS) in the relatives of schizophrenic patients. The experimental sample comprised 24 first-degree relatives of patients. Each relative was matched to one control. Cognitive tests were: Continuous Performance Test (CPT), N-Back Workin...
journal_title:Comprehensive psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.comppsych.2008.01.001
更新日期:2008-07-01 00:00:00