Frequency of reporting of adverse events in randomized controlled trials of psychotherapy vs. psychopharmacotherapy.


BACKGROUND:Psychopharmacology and psychotherapy are the two main therapies in mental health. It is common practice to consider adverse events (AEs) of medications, but it's not clear this occurs with psychotherapy. AIM:This study investigates the frequency with which reports of AEs occur in clinical trials using either psychopharmacology alone, psychotherapy alone, or combined approaches. METHODS:Forty-five articles of randomized trials published in high-impact journals were chosen from a Medline search, and separated into three groups of 15 articles: pharmacotherapy alone (M), psychotherapy alone (T) and combined studies that looked at the effect of both a psychotherapeutic (CT) and psychopharmacologic (CM) intervention. Criteria for what defines an AE were established and the papers were rated for mentions of AEs in papers as a whole and by each section. RESULTS:The χ(2)-analysis of AE mentions showed significant differences between the four study conditions in terms of each paper as a whole (χ(2):10.1,p<0.018), and by section. Medication (M+CM) and psychotherapy papers (T+CT) were then combined into two groups to compare the odds that one was more likely to mention AEs than the other. Bivariate logistic regression yielded statistically significant odds ratios ranging from 9.33 to 20.99, with medications being far more likely to mention AEs. CONCLUSION:We believe the difference in reports of AEs mirrors the attitudes researchers and providers. It's critical to consider, and standardize the definition of, AEs in psychotherapy, and imperative to identify and address potential AEs in psychotherapy research.


Compr Psychiatry


Comprehensive psychiatry


Vaughan B,Goldstein MH,Alikakos M,Cohen LJ,Serby MJ




Has Abstract


2014-05-01 00:00:00














  • Symptoms of disordered eating, body shape, and mood concerns in male and female Chinese medical students.

    abstract:OBJECTIVE:This cross-sectional study explored the prevalence of disordered eating attitudes, body shape concerns, and social anxiety and depressive symptoms in male and female medical students in China. METHOD:Four hundred eighty-seven students from Central South University (Hunan Province, Changsha City, China) compl...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Liao Y,Knoesen NP,Castle DJ,Tang J,Deng Y,Bookun R,Chen X,Hao W,Meng G,Liu T

    更新日期:2010-09-01 00:00:00

  • An investigation of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder construct as a prototype category and the psychometric properties of the diagnostic criteria.

    abstract::This study investigated several aspects of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder (APD) construct, with emphasis on the psychometric properties of the diagnostic criteria and the prototype nature of the construct. A sample of 1,058 patien...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章,多中心研究


    authors: Hummelen B,Wilberg T,Pedersen G,Karterud S

    更新日期:2006-09-01 00:00:00

  • Treating kleptomania: cross-cultural adaptation of the Kleptomania Symptom Assessment Scale and assessment of an outpatient program.

    abstract:BACKGROUND:Kleptomania is characterized by repetitive stealing and has severe consequences for patients. Stigma, a lack of standardized therapy and a limited number of assessment tools hinder advances in treatment. This study provides preliminary data on the Portuguese-language version of the Kleptomania Symptom Assess...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Christianini AR,Conti MA,Hearst N,Cordás TA,de Abreu CN,Tavares H

    更新日期:2015-01-01 00:00:00

  • The predictors of health care seeking behavior in obsessive-compulsive disorder.

    abstract::A majority of individuals with obsessive-compulsive disorder (OCD) do not seek health care. To better understand why not, health care-seekers (HCS) with OCD (n = 25) were compared with non-health care-seekers (NHCS) with OCD (n = 23) regarding their sociodemographic variables, symptom severity, types of obsessions and...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Beşiroğlu L,CIlli AS,Aşkin R

    更新日期:2004-03-01 00:00:00

  • A multidimensional spectrum approach to post-traumatic stress disorder: comparison between the Structured Clinical Interview for Trauma and Loss Spectrum (SCI-TALS) and the Self-Report instrument (TALS-SR).

    abstract::Dimensional approaches to psychiatric disorders have shown an increased relevance in the ongoing debate for the forthcoming Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In line with previously validated instruments for the assessment of different mood, anxiety, eating and psychotic spectra, we...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Dell'Osso L,Carmassi C,Rucci P,Conversano C,Shear MK,Calugi S,Maser JD,Endicott J,Fagiolini A,Cassano GB

    更新日期:2009-09-01 00:00:00

  • Freebase cocaine and memory.

    abstract::Despite the seriousness of acute medical and psychological consequences of cocaine abuse, little knowledge exists about the chronic effects of the drug. Investigation of a sample of abstinent freebase (crack) abusers in the Bahamas provides the first research evidence that prolonged cocaine abuse may result in persist...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Manschreck TC,Schneyer ML,Weisstein CC,Laughery J,Rosenthal J,Celada T,Berner J

    更新日期:1990-07-01 00:00:00

  • Disordered recognition and perception of human faces in acute schizophrenia and experimental psychosis.

    abstract::Three disorders of facial recognition and perception in acute schizophrenia and mescaline-induced psychosis are described and illustrated using original clinical and experimental material: "affective prosopagnosia" or stress-related dysfunctional face recognition; "physiognomization" of the environment or persistent i...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Harrington A,Oepen G,Spitzer M

    更新日期:1989-09-01 00:00:00

  • Prevalence of psychiatric disorders in patients with diabetes types 1 and 2.

    abstract:BACKGROUND:Diabetes mellitus, classified into types 1 and 2, is a chronic disease that shows high comorbidity with psychiatric disorders. Insulin-dependent patients show a higher prevalence of psychiatric disorders than do patients with type 2 diabetes. METHODS:This research involved the participation of 200 subjects ...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Maia AC,Braga Ade A,Brouwers A,Nardi AE,Oliveira e Silva AC

    更新日期:2012-11-01 00:00:00

  • Sleep problems among persons with a lifetime history of posttraumatic stress disorder alone and in combination with a lifetime history of other psychiatric disorders: a replication and extension.

    abstract:OBJECTIVE:Sleep problems are a clinical and/or diagnostic feature for a broad array of mood, substance use, and anxiety disorders, including posttraumatic stress disorder (PTSD). Previous research by Leskin et al (Leskin GA, Woodward SH, Young HE, Sheikh J. Effects of comorbid diagnoses on sleep disturbance in PTSD. J ...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Lauterbach D,Behnke C,McSweeney LB

    更新日期:2011-11-01 00:00:00

  • The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:A number of studies about attention-deficit/hyperactivity disorder (ADHD) and Internet video game play have examined the prefrontal cortex and dopaminergic system. Stimulants such as methylphenidate (MPH), given to treat ADHD, and video game play have been found to increase synaptic dopamine. We hypothesized ...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Han DH,Lee YS,Na C,Ahn JY,Chung US,Daniels MA,Haws CA,Renshaw PF

    更新日期:2009-05-01 00:00:00

  • Does late onset depression predispose to dementia? A retrospective, case-controlled study.

    abstract:BACKGROUND:Recent research suggests that there are clinical and biologic characteristics typical of late onset depression (LOD). Furthermore, evidence has been put forward that LOD may be a prodrome of dementia. OBJECTIVE:This study aims to assess the association between LOD and the development of dementia. SETTING:T...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Ohanna I,Golander H,Barak Y

    更新日期:2011-11-01 00:00:00

  • Targeting remission by 8 weeks: when should supplementation be considered in patients with major depression treated with a specific serotonin reuptake inhibitor?

    abstract:BACKGROUND:Timely administration/supplementation of a specific serotonin reuptake inhibitor with a second therapeutic agent could improve treatment outcome in patients with major depressive disorder (MDD). The purpose of this study was to identify the optimal time at which to implement supplementation so as to maximize...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Cooper-Kazaz R,Rigbi A,Lerer B

    更新日期:2011-01-01 00:00:00

  • Employment program for patients with severe mental illness in Malaysia: a 3-month outcome.

    abstract:OBJECTIVE:This study aimed to examine the rate and predictive factors of successful employment at 3 months upon enrolment into an employment program among patients with severe mental illness (SMI). METHODS:A cross-sectional study using universal sampling technique was conducted on patients with SMI who completed a 3-m...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Wan Kasim SH,Midin M,Abu Bakar AK,Sidi H,Nik Jaafar NR,Das S

    更新日期:2014-01-01 00:00:00

  • Clinical characteristics of mania, mixed mania, and bipolar depression with psychotic features.

    abstract::This study investigated a series of clinical characteristics, including the level of insight into illness and axis I comorbidity, in 125 patients with bipolar disorder with psychotic features categorized in three groups: 62 patients with mania, 28 patients with mixed mania, and 35 patients with depression. All patient...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Dell'Osso L,Pini S,Tundo A,Sarno N,Musetti L,Cassano GB

    更新日期:2000-07-01 00:00:00

  • Initial stages of validation by penile volume assessment that sexual orientation is distributed dimensionally.

    abstract::Kinsey concluded that homosexuality and heterosexuality were distributed dimensionally in the normal population, a significant percentage of whom experienced homosexual feelings. This conclusion has been ignored by most sex researchers. Twenty men seeking treatment for compulsive sexual behaviours reported a dimension...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: McConaghy N,Blaszczynski A

    更新日期:1991-01-01 00:00:00

  • Types of childhood trauma and spirituality in adult patients with depressive disorders.

    abstract:OBJECTIVE:The aim of this study was to investigate the differences in spirituality among adult patients with depressive disorders, who had suffered various types of abuse or neglect in childhood. METHODS:A total of 305 outpatients diagnosed with depressive disorders completed questionnaires on socio-demographic variab...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Song JM,Min JA,Huh HJ,Chae JH

    更新日期:2016-08-01 00:00:00

  • Risk factors of transition from mild cognitive impairment to Alzheimer's disease and death: A cohort study.

    abstract:BACKGROUND:Knowledge of risk factors is essential for developing strategies that prevent or minimise transitions from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and death. The aim of this study was to assess risk factors for progression to AD and death among Chinese individuals with cognitive impairmen...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Xue H,Sun Q,Liu L,Zhou L,Liang R,He R,Yu H

    更新日期:2017-10-01 00:00:00

  • Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients.

    abstract:BACKGROUND:OCD causes impairment in different areas of the patients' quality of life (QoL), such as sociability, family relationships, and occupational performance. The literature has emphasized the relevance of assessing QoL as a critical outcome in mental health studies. AIMS:The aim of this study was to investigate...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Velloso P,Piccinato C,Ferrão Y,Perin EA,Cesar R,Fontenelle LF,Hounie AG,do Rosário MC

    更新日期:2018-10-01 00:00:00

  • The cognitive structure of higher functioning autism and schizophrenia: a comparative study.

    abstract::The purpose of this study was to examine whether performance on a standard cognitive test-battery can be used to clearly separate higher functioning autism from schizophrenia. Revised Wechsler Intelligence Scale for Children (WISC-R) or Adults (WAIS-R) profiles of 20 autistic and 20 schizophrenic adolescent young adul...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Bölte S,Rudolf L,Poustka F

    更新日期:2002-07-01 00:00:00

  • Brain activity and desire for Internet video game play.

    abstract:OBJECTIVE:Recent studies have suggested that the brain circuitry mediating cue-induced desire for video games is similar to that elicited by cues related to drugs and alcohol. We hypothesized that desire for Internet video games during cue presentation would activate similar brain regions to those that have been linked...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Han DH,Bolo N,Daniels MA,Arenella L,Lyoo IK,Renshaw PF

    更新日期:2011-01-01 00:00:00

  • Why must some schizophrenic patients be involuntarily committed? The role of insight.

    abstract::Twenty-four of 52 (46%) schizophrenic patients hospitalized because of acute psychotic episodes associated with preadmission medication noncompliance required involuntary commitment. Committed patients were rated as significantly more severely ill than voluntary patients and were significantly more likely to be transf...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: McEvoy JP,Applebaum PS,Apperson LJ,Geller JL,Freter S

    更新日期:1989-01-01 00:00:00

  • Gender and age differences in suicide mortality in the context of violent death: findings from a multi-state population-based surveillance system.

    abstract:OBJECTIVE:Males are more likely than females to die by all forms of violent death, including suicide. The primary purpose of the present study was to explore whether the gender difference in suicide rates is largely accounted for by males' general greater tendency to experience violent deaths. The current study examine...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Bozzay ML,Liu RT,Kleiman EM

    更新日期:2014-07-01 00:00:00

  • Social connectedness, stressful life events, and self-injurious thoughts and behaviors among young adults.

    abstract:OBJECTIVES:Preventing self-injurious thoughts and behaviors (SITBs) is particularly challenging on commuter campuses, given lower social cohesion and higher levels of stress than among traditional college populations. The present study examined the relationship between stressful life events (SLEs) and risk for differen...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Macrynikola N,Miranda R,Soffer A

    更新日期:2018-01-01 00:00:00

  • Gender differences in patients with schizophrenia and substance abuse.

    abstract::Co-occurring substance abuse is common among people with chronic mental illnesses such as schizophrenia. Although gender differences have been established among substance abusers in the general population and among people with schizophrenia, little is known about gender differences in people with the dual disorders of...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Brunette MF,Drake RE

    更新日期:1997-03-01 00:00:00

  • The validation study and application of stratum-specific likelihood ratios in the Chinese version of SPAN.

    abstract::The Davidson Trauma Scale (DTS) is a validated self-rating scale used in the diagnosis of post-traumatic stress disorder (PTSD). A shorter version of the DTS was developed to serve as a diagnostic screening tool. A four-item scale, the SPAN (named for its principal four items: Startle, Physiological arousal, Anger, an...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Chen CH,Shen WW,Tan HK,Chou JY,Lu ML

    更新日期:2003-01-01 00:00:00

  • Childhood abuse, adult assault, and dissociation.

    abstract::Recent studies have suggested an association between childhood physical and sexual abuse and adult dissociative experiences. The purpose of this study was to determine the relationship of both childhood and adult-onset abuse and their characteristics for adult dissociative symptoms. One hundred forty-four psychiatric ...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Lipschitz DS,Kaplan ML,Sorkenn J,Chorney P,Asnis GM

    更新日期:1996-07-01 00:00:00

  • The development, use, and reliability of the brief psychiatric rating scale (nursing modification)--an assessment procedure for the nursing team in clinical and research settings.

    abstract::The role of nursing staff in the systematic rating of psychopathology has been explored in a small number of studies in recent years. Nurses are uniquely placed to carry out relatively continuous observations of high validity which are sensitive to change, yet on the basis of the limited data available, some doubts re...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: McGorry PD,Goodwin RJ,Stuart GW

    更新日期:1988-11-01 00:00:00

  • Hippocampal shape alterations in healthy young women with familial risk for unipolar depression.

    abstract:BACKGROUND:Although reduced hippocampal volume (HCV) is a common finding in depression, it is unclear whether the structural alterations leading to reduction of HCV are pre-existing risk factors before the onset of clinical symptoms or a cumulative process that begins with the onset of clinical symptoms. The aim of the...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Durmusoglu E,Ugurlu O,Akan S,Simsek F,Kizilates G,Kitis O,Ozkul BA,Eker C,Coburn KL,Gonul AS

    更新日期:2018-04-01 00:00:00

  • The sequence of improvement of the symptoms encountered in patients with panic disorder.

    abstract::Patients who meet DSM-III-R criteria for a diagnosis of panic disorder often show a complex mixture of psychopathological symptoms, including panic attacks (spontaneous and situational), anxiety (anticipatory and generalized), phobias (fear and avoidance), depression/dysphoria, and social and occupational disability. ...

    journal_title:Comprehensive psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Deltito JA,Argyle N,Buller R,Nutzinger D,Ottosson JO,Brandon S,Mellergard M,Shera D

    更新日期:1991-03-01 00:00:00

  • Types of panic attacks and their association with psychiatric disorder and physical illness.

    abstract::The differentiation of three types of panic attacks is proposed to be significant for understanding the course and etiology of panic and other psychiatric disorders and physical illnesses. The present investigation is based on longitudinal data from the Epidemiologic Catchment Area (ECA) Study of 1980 to 1981 and its ...

    journal_title:Comprehensive psychiatry

    pub_type: 杂志文章


    authors: Bovasso G,Eaton W

    更新日期:1999-11-01 00:00:00