Abstract：
:Recent research has supported a potential role of immune pathology in the etiopathogenesis of schizophrenic. In the CNS various viruses were identified in the brains of schizophrenic patients. Pro-inflammatory cytokines were found to be associated with the stage of disease. Microglial cells were reported to be activated in a subgroup of schizophrenic patients in post mortem as well as imaging studies. New research has demonstrated that astrocytes together with microglial cells are the major immunocompetent cells of the brain and play an important role in the regulation of neuronal proliferation and differentiation. S100B, a calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation. Scientific evidence for increased S100B in acute schizophrenia is very consistent. The picture is not as clear regarding schizophrenia subtypes in acute states but patients with persistent negative symptoms or deficit syndrome show constant high S100B concentrations. There is an association between high S100B and poor therapeutic response. The increased S100B concentrations appear to be functionally relevant since they are reflected by poor cognitive performance and cross validation with other methods make it unlikely that the findings are merely an epiphenomenon. These findings suggest that the activation of astrocytes might be an important pathogenic factor for the development of schizophrenia.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Rothermundt M,Ahn JN,Jörgens Ssubject
Has Abstractpub_date
2009-01-01 00:00:00pages
F76-81eissn
0231-5882issn
1338-4325journal_volume
28 Spec No Focuspub_type
杂志文章,评审abstract：:In P-gp-positive cell variants obtained from L1210 cells either by selection with vincristine (L1210/R) or by transfection with the human gene encoding P-gp (L1210/T), we have previously described cross-resistance to tunicamycin (TNM), a protein N-glycosylation inhibitor. Here we studied whether this cross-resistance ...
journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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doi：
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journal_title：General physiology and biophysics
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doi：
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：1995-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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doi：
更新日期：1983-10-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：1992-02-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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更新日期：1991-10-01 00:00:00
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journal_title：General physiology and biophysics
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更新日期：2000-09-01 00:00:00
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