Abstract：
:Lidocaine, a use-dependent Na(+) channel blocker, paradoxically evokes neural activation in the slowly adapting stretch receptor organ of crayfish at 5-10 mmol/l concentration. For elucidating the underlying mechanisms of this paradoxical effect, a series of conventional electrophysiological experiments were performed in the stretch receptor neurons of crayfish. In the presence of tetrodotoxin, lidocaine did not evoke impulse activity, however, a slowly developing and dose-dependent depolarization occurred in both the rapidly and slowly adapting stretch receptors. Similar effects were observed by perfusion of equivalent concentrations of benzocaine but not of procaine or prilocaine. Lidocaine did not evoke neural activity in the rapidly adapting neuron which fires action potential(s) in response to rapid changes in membrane potential. Slowly developing mode of the depolarization indicated the reason why only depolarization but not action potential responses were observed in the rapidly adapting neuron. The depolarizing effect of lidocaine was independent from any ionic channel or exchanger system. However, lidocaine and benzocaine but not procaine and prilocaine evoked a dose-dependent alteration in the input resistance of the neuron. It was proposed that the principal mechanism of the effect could stem from a change in the physical properties of the neuronal membrane.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Keceli MB,Purali Nsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
20-6issue
1eissn
0231-5882issn
1338-4325journal_volume
26pub_type
杂志文章abstract：:Expression of the haptoglobin (Hp) gene is liver specific and acute phase (AP) responsive. It was previously shown that transcriptional induction process of the rat Hp gene during turpentine induced AP response has been mediated by the liver nucleoprotein p29 which was shown to be homologous to the HMG-1 chromatin-ass...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:A simple graphical method is proposed to distinguish between two-state and gradual alterations in DNA conformation from circular dichroic spectra. The method is advantageous particularly to identify two-state conformational isomerizations which exhibit low degree of cooperativity. The usefulness of the method is illus...
journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：1986-08-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017021
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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更新日期：2001-06-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
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journal_title：General physiology and biophysics
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更新日期：1984-08-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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journal_title：General physiology and biophysics
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doi：10.4149/gpb_2011_01_34
更新日期：2011-03-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：1999-12-01 00:00:00
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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doi：
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journal_title：General physiology and biophysics
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doi：
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journal_title：General physiology and biophysics
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更新日期：1992-10-01 00:00:00
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journal_title：General physiology and biophysics
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更新日期：1988-02-01 00:00:00
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
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journal_title：General physiology and biophysics
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更新日期：1998-06-01 00:00:00
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