Abstract:
:Quercetin and epigallocatechin gallate are two of the most abundant polyphenols in dietary plants, including apples, onions, red wine and green tea. The bioactivity of polyphenols is linked to their ability to interact with cell membranes without being internalized. The aim of the present study was to assess the short-time effect of these polyphenols on membrane anisotropy and transmembrane potential of U937 monocytes and Jurkat T lymphoblasts. Results showed that quercetin and epigallocatechin gallate induced, after 20 minutes cell exposure, a dose-dependent increase of membrane anisotropy and polarization. Anisotropy increase was correlated with the reduction of lipid peroxidation. Our results could indicate that the antioxidant capacity of the tested polyphenols is due to their stabilizing effect on the cell membranes, thus contributing to cell protection in various pathologies and as adjuvant therapy in highly toxic treatment regimens.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Margina D,Ilie M,Manda G,Neagoe I,Mocanu M,Ionescu D,Gradinaru D,Ganea Cdoi
10.4149/gpb_2012_005subject
Has Abstractpub_date
2012-03-01 00:00:00pages
47-55issue
1eissn
0231-5882issn
1338-4325journal_volume
31pub_type
杂志文章abstract::This study specified the role of several key calcium-operating ion channels in contraction/relaxation of human detrusor muscle as possible target for overactive bladder (OAB) treatment. Detrusor samples, obtained from 18 males (average age 61.5 ± 5.9 years), were investigated by organ tissue bath method with following...
journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
pub_type: 杂志文章,评审
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2017021
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journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
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journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
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doi:10.4149/gpb_2009_04_371
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journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2012_019
更新日期:2012-06-01 00:00:00
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journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2013070
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pub_type: 杂志文章
doi:10.4149/gpb_2016001
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
pub_type: 杂志文章
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journal_title:General physiology and biophysics
pub_type: 杂志文章,评审
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