Abstract：
:It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, in storage media as well as in peripheral circulation, they undergo a variety of biochemical changes. In our study, the erythrocytes with different age groups in citrate phosphate dextrose adenine-formula 1 (CPDA-1) storage solution were used in order to investigate the possible effect of gender factor on oxidative damage. Oxidative damage biomarkers in erythrocyte membranes such as ferric reducing antioxidant power, pro-oxidant-antioxidant balance, protein-bound advance glycation end products, and sialic acid were analyzed. Current study reveals that change in membrane redox status during blood-bank storage condition also depends on both gender depended homeostatic factors and the presence of CPDA-1. During the storage period in CPDA-1, erythrocytes from the male donors are mostly affected by free radical-mediated oxidative stress but erythrocytes obtained from females are severely affected by glyoxidative stress.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Erman H,Aksu U,Belce A,Atukeren P,Uzun D,Cebe T,Kansu AD,Gelişgen R,Uslu E,Aydın S,Çakatay Udoi
10.4149/gpb_2016001subject
Has Abstractpub_date
2016-07-01 00:00:00pages
343-51issue
3eissn
0231-5882issn
1338-4325journal_volume
35pub_type
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