Abstract：
:2-3-dimercapto-1-propane sulfonic acid, D-penicillamine and meso-dimercapto succinic acid, drugs widely applied as antidota against metal poisoning, and cysteine and glutathione were studied with respect to their ability to generate and to scavenge superoxide anion radical. Superoxide production and scavenging were tested by means of luminol-dependent chemiluminescence. In presence of 1 mumol/l ADP-Fe3+ only cysteine and meso-dimercapto succinic acid induced chemiluminescence which could be inhibited by superoxide dismutase. 2,3-dimercapto-1-propane sulfonic acid, D-penicillamine and glutathione acted as O2- scavengers. These thiols inhibited O2(-)-dependent lipid peroxidation thus acting as antioxidants, whereas cysteine and meso-dimercapto succinic acid accelerated peroxidation. It is suggested that the toxic side effects of thiols may be due to their ability to generate or to scavenge free radicals.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Benov LC,Ribarov SR,Monovich OHsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
195-202issue
2eissn
0231-5882issn
1338-4325journal_volume
11pub_type
杂志文章abstract：:Homocysteine (Hcys) may be implicated in different diseases, especially in cardiovascular illnesses. The most reactive form of Hcys is its cyclic thioester-homocysteine thiolactone (HTL), which is formed in plasma and represents up to 0.29% of plasma total Hcys. Recently, it has been observed that Hcys and HTL may mod...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2010_02_186
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：2001-09-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：2008-09-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017007
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
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更新日期：2011-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017033
更新日期：2017-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2019044
更新日期：2020-01-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：:The effects of ryanodine on negative force staircase and potentiated rested-state contraction (RC) in rat myocardium were compared to the action of Ca release stimulator (caffeine) and inhibitors (local anesthetics). Only low ryanodine concentrations (0.1-0.5 mumol/l) were found to reverse anomalous mechanical pattern...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice...
journal_title：General physiology and biophysics
pub_type： 杂志文章
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
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更新日期：2007-06-01 00:00:00
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journal_title：General physiology and biophysics
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更新日期：2010-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The purpose of this study was to assess the possible protective effects of Artemisia campestris against fenthion-induced nephrotoxicity in adult rats and their progeny. Fenthion was administered orally at a dose of 551 ppm, which represented ¼ of LD50, for 21 consecutive days to pregnant and lactating rats. Oxidative ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2013047
更新日期：2013-12-01 00:00:00
abstract：:Aiming at making the Münch model more adequate to the biological reality we introduce certain modifications and complements. Considering the model within the framework of so-called integrated system of long-distance water transport in plants we present a quantitative analysis based on the Kedem-Katchalsky formalism. A...
journal_title：General physiology and biophysics
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
abstract：:The dynamics of a bioreactor with a variable volume and an active solute flux based on the thermodynamics of irreversible processes and stability analysis was studied. The active solute flux may control both the bioreactor volume and the hydrostatic pressure as well as the concentration of the solute inside the cell i...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:The relationship between erythrocyte shape and the critical cell volume was investigated. Agents able to increase the critical cell volume induced three main stable shapes of erythrocytes: discocytic, stomatocytic, and echinocytic. The absence of correlation between shape and critical cell volume under isoosmotic cond...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:In this study, we investigated the role of AMP-activated protein kinase (AMPK) and the importance of reactive oxygen species (ROS) in apoptosis induction associated with cell cycle arrest induced by sulforaphane in AGS human gastric cancer cells. Our results demonstrated that sulforaphane inhibited proliferation of AG...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017026
更新日期：2018-03-01 00:00:00
