Abstract:
:Results of studies on the modulation of skeletal muscle contraction by phosphorylation of myosin regulatory light chains and by exchange of magnesium for calcium in myosin heads were reviewed. The polarized fluorescence method was used in these studies, and conformational changes of contractile proteins accompanying modulation of skeletal muscle contraction were investigated. It was found that both the exchange of bound magnesium for calcium on myosin heads and the phosphorylation of myosin regulatory light chains control the ability of myosin heads to induce, upon binding to actin, conformational changes of thin filament leading to decrease or increase of its flexibility. The changes in actin filament flexibility may be caused by alteration of both the inter- and the intramonomer structural organization.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Borovikov YuS,Kakol Isubject
Has Abstractpub_date
1991-06-01 00:00:00pages
245-64issue
3eissn
0231-5882issn
1338-4325journal_volume
10pub_type
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