Abstract:
:Fasting for 48 h and the same period of recovery induced by 48 h refeeding increased rat hypothalamic monoamine oxidase (MAO) activity. However, in the interscapular brown adipose tissue (IBAT), only refeeding induced a significant elevation of the enzyme activity. As far as hypothalamic antioxidative enzymes are concerned, the copper zinc superoxide dismutase (CuZnSOD) activity was decreased in refed rats only. However, in the IBAT both food deprivation and refeeding induced a significant decrease in catalase (CAT) activity. Under the influence of fasting the adrenal glands were strongly activated as judged by the increased dopamine-beta-hydroxylase (DBH) activity and decreased cholesterol concentration. Refeeding brought both parameters to control levels indicating full recovery of these glands. As expected, fasting for 48 h induced a significant decrease in serum glucose but an increase in FFA concentrations. Thus, it can be concluded that both fasting and refeeding resulted in increased activation of hypothalamic MAO, whereas CuZnSOD activity was decreased only by refeeding. However, in the IBAT only refeeding increased MAO activity whereas both fasting and refeeding decreased that of CAT. In conclusion, it may be assumed that food deprivation for 48 h and the same duration of refeeding influenced MAO and antioxidative enzymes activities in the rat hypothalamus and IBAT in a tissue specific manner.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Cvijic G,Djordjevic J,Davidovic Vsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
305-16issue
3eissn
0231-5882issn
1338-4325journal_volume
19pub_type
杂志文章abstract::This study investigated time-dependent variations in the activities of adenosine deaminase (ADA), an adenosine-metabolizing enzyme, and myeloperoxidase (MPO), an oxidation reaction-catalyzing enzyme, in control and streptozotocin (STZ)-induced diabetic rat liver. The animals were sacrificed at six different times of d...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb-2019057
更新日期:2020-03-01 00:00:00
abstract::Low-conductance chloride channel from skeletal muscle SR vesicles of the crayfish Astacus fluviatilis was incorporated into planar lipid bilayers and its basic characteristics were investigated. The channel has a relatively low unitary conductance of 26 pS in symmetrical 160 mmol/l choline-chloride. The dependence of ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::We studied physical properties of the monolayers and bilayer lipid membranes (BLM) formed by calix[6]arene carboxylic acid derivative (CX) and its mixtures with diphytanoylphosphatidylcholine (DPhPC) by means of measurement surface pressure, surface dipole potential and electrostriction. CX forms stable monolayers at ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2013024
更新日期:2013-06-01 00:00:00
abstract::Hyperlipidemia is found to be associated with changes in fatty acid (FA) profiles. The aim of this study was to investigate the effects of AHA-Step-1 dietary treatment and combination of fibrates (gemfibrozil) with dietary intervention on serum and erythrocyte phospholipid FA composition in human hyperlipidemia. 78 st...
journal_title:General physiology and biophysics
pub_type: 临床试验,杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused ...
journal_title:General physiology and biophysics
pub_type: 杂志文章,评审
doi:10.4149/gpb_2013067
更新日期:2013-12-01 00:00:00
abstract::Various techniques have been used (UV absorbance and fluorescence spectroscopy, polarised UV fluorescence microscopy, viscosimetry, electrophoresis and isoelectric focusing, superprecipitation, etc.) As suggested by several parameters, denervation interferes with the structure of actin by producing local conformation ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Activated endothelial cells play a crucial role in the formation of new blood vessels, a process known as angiogenesis, which can underlie the development of several diseases. Different antiangiogenic therapies aimed against vascular endothelial growth factor (VEGF), the dominant pro-angiogenic cytokine, have been dev...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2018047
更新日期:2019-03-01 00:00:00
abstract::The present results suggest that laminin-1 and 3 are localized in the specialized Schwann cells of Pacinian corpuscles, in spite of incomplete deposition of the basal lamina on the surface of their cytoplasmic processes. In addition, laminin-3 is concentrated and probably function as a stop protein not only in the neu...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The substantia gelatinosa of the trigeminal subnucleus caudalis has been considered to be an essential location for the transference of orofacial sensory signals. The co-localization of inhibitory and excitatory neurotransmitters in the same substantia gelatinosa (SG) neurons has demonstrated their essential part in t...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019027
更新日期:2019-09-01 00:00:00
abstract::The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2013070
更新日期:2014-01-01 00:00:00
abstract::he secondary structure of membrane proteins was studied in rat heart sarcolemma by circular dichroism under conditions of interaction with metallic cofactors of (Na+ + K+)-ATPase at their optimal concentrations and under metal free conditions. Approximately 80 per cent of polypeptide chains in the membrane were organi...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::Icaritin, a prenylflavonoid derivative from Epimedium Genus, has been reported to exhibit tumor inhibitory effects on many types of tumor cells. Numerous studies have demonstrated that microRNAs (miRs) involve in the biological process of carcinogenesis by controlling expression of their target mRNAs to facilitate tum...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019041
更新日期:2019-11-01 00:00:00
abstract::Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2017049
更新日期:2018-05-01 00:00:00
abstract::The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant a...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2012_019
更新日期:2012-06-01 00:00:00
abstract::The distributions of K, Na, Mg and Ca within frog ovarian and oviductal oocytes were studied by electron probe wavelength dispersive X-ray microanalysis. An important heterogeneity could be found both in nuclear and jelly coated oocytes. The highest K, Mg and, to a lesser extent, Na concentrations were found in the pi...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::Maternal milk is a significant source of hormones and other bioactive substances. They might be involved either in the control of mammary gland function or in the regulation of growth and development of the neonate. Atriopeptin (atrial natriuretic factor, ANF) is a peptide with strong diuretic, natriuretic and vasorel...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Apoptosis (programmed cell death) is an important process participating in the formation of organs and tissues during embryogenesis. Our aim of the work is studying the role of the apoptosis during the human embryonic differentiation. We tend to give acquired findings into the correlation with expression of proteins B...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The plasma membrane H(+)-ATPase of Neurospora has been reconstituted into planar lipid bilayer membranes by means of the vesicle-fusion technique described by Finkelstein and his collaborators (Zimmerberg et al., 1980; Cohen et al., 1980, 1984; Akabas et al., 1984). Enzyme was first transferred from isolated plasma me...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Cytochrome P-450 and NADPH: cytochrome P-450 reductase were solubilized by detergents from microsomal fraction of tulip bulbs Tulipa fosteriana L. and purified to electrophoretic homogeneity. The purification was achieved by anion-exchange column chromatography, hydroxyapatite-column chromatography and affinity chroma...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::A simple graphical method is proposed to distinguish between two-state and gradual alterations in DNA conformation from circular dichroic spectra. The method is advantageous particularly to identify two-state conformational isomerizations which exhibit low degree of cooperativity. The usefulness of the method is illus...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract::The interactions between haematoporphyrin (HP) and bilayer lipid membranes (BLM) were studied. A weak effect of HP on BLM conductivity was observed at HP concentrations ranging between 10(-6) and 3 x 10(-5) mol/l. Modulus of elasticity in the direction normal to the membrane plane (E perpendicular) and dynamic viscosi...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::The dynamics of a bioreactor with a variable volume and an active solute flux based on the thermodynamics of irreversible processes and stability analysis was studied. The active solute flux may control both the bioreactor volume and the hydrostatic pressure as well as the concentration of the solute inside the cell i...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::Thermal inactivation of peroxidase (POD) in an extract of Picea omorika (Pancić) Purkyne needles initiated by heat treatment was studied. This is the first study of this kind on a conifer species. Non-linear regression analysis was applied on the inactivation rate data, combining Mitscherlich and Arrhenius equations, ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2009_01_78
更新日期:2009-03-01 00:00:00
abstract::The effects of thrombin stimulation on megakaryocytopoiesis and pulmonary-platelet interactions were investigated before and after administration of the compound to 15 mongrel dogs. Each dog served as its own control. Thrombin was given to encourage the traffic of megakaryocytes into the lung and to study the thrombin...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::The passive mechanical properties of whole muscle in active and nonactive states are compared. The experimental results are presented as stress-strain curves, which are analyzed in the framework of the current theoretical background [viz. the freely-jointed chain model (FJCM) and the worm-like chain model (WLCM)] in a...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent antioxidant. When applied systematically, 7,8-DHF can pass through blood-brain barrier and exhibit potential therapeutic effects in several animal models of neurodegenerative disorders. This study investi...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2020022
更新日期:2020-09-01 00:00:00
abstract::Binding of the tricyclic antidepressant imipramine (IMI) to neutral and negatively charged lipid membranes was investigated using a radioligand binding assay combined with centrifugation or filtration. Lipid bilayers were composed of brain phosphatidylcholine (PC) and phosphatidylserine (PS). IMI binding isotherms wer...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::The effects of alamethicin on the membrane barrier function of rabbit erythrocytes, human platelets and sarcoplasmic reticulum vesicles, as well as on that of brain microsomes and liver mitochondria of the rat were compared. An upset of the barrier function was observed for plasma membranes of brain microsomes as well...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::The aim of this paper was to study the protein remodelling of the left ventricle following repeated administration of either daunorubicin (DNR) or DNR in combination with the cardioprotective agent dexrazoxane (DXZ). The experiment was carried out on three groups of Chinchilla male rabbits: 1. DNR (3 mg/kg i.v.), 2. D...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00