Abstract：
:The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant and nursing rats of the control group drank water. Electrophysiological experiments (repeated electrical stimulation and analysis of cortical afterdischarges duration) were than performed on their immature offspring. Rat pups were tested on postnatal day 18, 25, and 35. Shortening of afterdischarges duration was observed in 18-day-old animals (mothers drank 20% ethanol) when compared with age matched controls and failure of post-ictal depression phenomenon was found in 25- and 35-day-old animals. Our findings signalize that ethanol exposure during pregnancy influences seizure susceptibility by acting on excitatory/inhibitory brain systems and this effect is dose- and age-dependent.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Riljak V,Maresova D,Jandova K,Bortelova J,Pokorny Jdoi
10.4149/gpb_2012_019subject
Has Abstractpub_date
2012-06-01 00:00:00pages
173-7issue
2eissn
0231-5882issn
1338-4325journal_volume
31pub_type
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更新日期：1999-10-01 00:00:00
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