Abstract:
:Salts of divalent cadmium are well-known human mutagens and carcinogens. In the present work, the ability of vitamin C to modulate genotoxic effects of cadmium chloride on human lymphocytes was assessed using single cell gel electrophoresis (comet assay). Vitamin C at 20 and 100 micromol/l and cadmium at 5, 30 and 150 micromol/l significantly increased the tail moment of lymphocytes. Vitamin C also increased the tail moment of cells exposed to cadmium. This effect was concentration-dependent: the higher the vitamin C concentration the greater the tail moment. The combined effects of cadmium and vitamin C were more pronounced at all concentrations tested than the sum of the effects of the compounds applied separately (p < 0.05), so cadmium and vitamin C can be considered to have synergistic effects. The results obtained can be partly explained by the participation of cadmium in the Fenton reaction and reduction of its oxidized form by vitamin C.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Błasiak J,Trzeciak A,Dziki A,Ulańska J,Pander Bsubject
Has Abstractpub_date
2000-12-01 00:00:00pages
373-9issue
4eissn
0231-5882issn
1338-4325journal_volume
19pub_type
杂志文章abstract::The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant a...
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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doi:
更新日期:1984-04-01 00:00:00
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更新日期:2003-12-01 00:00:00
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journal_title:General physiology and biophysics
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doi:
更新日期:1992-02-01 00:00:00
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更新日期:2004-03-01 00:00:00
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journal_title:General physiology and biophysics
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doi:
更新日期:2000-09-01 00:00:00
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journal_title:General physiology and biophysics
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更新日期:2005-06-01 00:00:00
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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journal_title:General physiology and biophysics
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