Serum and erythrocyte membrane phospholipids fatty acid composition in hyperlipidemia: effects of dietary intervention and combined diet and fibrate therapy.

abstract：:S100A1 is a Ca2+-binding protein expressed at high levels in the myocardium. It is thought to modulate the Ca2+ sensitivity of the sarcoplasmic reticulum (SR) Ca2+ release channels (ryanodine receptors or RyRs) and its expression has been shown to be down regulated in various heart diseases. In this study we used S100...

journal_title：General physiology and biophysics

authors： Gusev K,Ackermann GE,Heizmann CW,Niggli E

更新日期：2009-12-01 00:00:00

abstract：:The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically ...

journal_title：General physiology and biophysics

authors： Yang CL,Zeng YD,Hu ZX,Liang H

更新日期：2020-03-01 00:00:00

abstract：:The relationship between erythrocyte shape and the critical cell volume was investigated. Agents able to increase the critical cell volume induced three main stable shapes of erythrocytes: discocytic, stomatocytic, and echinocytic. The absence of correlation between shape and critical cell volume under isoosmotic cond...

journal_title：General physiology and biophysics

authors： Mosior M,Białas WA,Wróbel A,Gomułkiewicz J

更新日期：1992-10-01 00:00:00

abstract：:It is currently believed that the protein folding rate is related to the protein structures and its amino acid sequence. However, few studies have been done on the problem that whether the protein folding rate is influenced by its corresponding mRNA sequence. In this paper, we analyzed the possible relationship betwee...

journal_title：General physiology and biophysics

authors： Li RF,Li H

更新日期：2011-06-01 00:00:00

abstract：:The human pituitary tumor-transforming gene-1 (hPTTG1) has been found to be overexpressed in various cancers. Accumulated evidences implicate that some of protein kinases can specifically recognize two PXXP motifs at hPTTG1 C-terminus through their Src homology (SH3) domain and then phosphorylate the protein by their ...

journal_title：General physiology and biophysics

authors： Li Y,Li M,Min W,Han G,Wang L,Chen C,Li Z,Zhang Y,Li J,Yue Z

更新日期：2017-01-01 00:00:00

abstract：:Overconsumption of fructose increases the risk of nonalcoholic fatty liver disease (NAFLD), obesity and metabolic syndrome. NAFLD is currently one of the most common etiologies of chronic liver disease worldwide. The aim of the present study is to evaluate the hepatoprotective potential of zingerone against fructose-e...

journal_title：General physiology and biophysics

authors： Muniandy Narayanan J,Jesudoss VA

更新日期：2016-04-01 00:00:00

abstract：:Lignin, the structural polymer of the plant cell walls, is produced by free radical polymerization of phenolic alcohols, catalyzed by different peroxidases. The mechanism and the structural organization of lignin in the cell have not been completely understood. In this study we applied fractal analysis to images of li...

journal_title：General physiology and biophysics

authors： Radotić K,Tasić M,Jeremić M,Budimlija Z,Simić-Krstić J,Polzović A,Bozović Z

更新日期：2000-06-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of resveratrol on cytogenetic damages of iododeoxyuridine (IUdR) and x-ray megavoltage radiation (6 MV) in spheroid model of U87MG glioblastoma cancer cell line using clonogenic and alkaline comet assay. Cells were cultured as spheroids (350 µm) that were treated wi...

journal_title：General physiology and biophysics

authors： Firouzi F,Khoei S,Mirzaei HR

更新日期：2015-01-01 00:00:00

abstract：:Nucleosome sliding and nucleosome digestion are two main ways for regulating gene transcription. We constructed three characteristic parameters (CP) based on the information of CG0, CG1 and CG2 motifs, and used these parameters to analyze the sliding trend of -1 and +1 nucleosomes around TSS of genes with NFR in yeast...

journal_title：General physiology and biophysics

authors： Meng H,Li H,Yang Z,Si Y

更新日期：2020-05-01 00:00:00

abstract：:The postnatal developmental changes in mitochondrial uncoupling protein 1 (UCP 1) and F1-ATP synthase (ATPase) subunit levels in the interscapular brown adipose tissue (BAT) were studied in golden Syrian hamsters (Mesocricetus auratus) using electron microscopy in situ immunocytochemistry. The relatively low initial d...

journal_title：General physiology and biophysics

authors： Bednár J,Soukup T

更新日期：2003-12-01 00:00:00

abstract：:Activated endothelial cells play a crucial role in the formation of new blood vessels, a process known as angiogenesis, which can underlie the development of several diseases. Different antiangiogenic therapies aimed against vascular endothelial growth factor (VEGF), the dominant pro-angiogenic cytokine, have been dev...

journal_title：General physiology and biophysics

authors： Horváthová J,Moravčík R,Boháč A,Zeman M

更新日期：2019-03-01 00:00:00

abstract：:Expression of the haptoglobin (Hp) gene is liver specific and acute phase (AP) responsive. It was previously shown that transcriptional induction process of the rat Hp gene during turpentine induced AP response has been mediated by the liver nucleoprotein p29 which was shown to be homologous to the HMG-1 chromatin-ass...

journal_title：General physiology and biophysics

authors： Grigorov I,Milosavljević T,Cvetković I,Petrović M

更新日期：2001-12-01 00:00:00

abstract：:We studied the involvement of O2, pH and low molecular thiols in H2S-induced decomposition of S-nitrosoglutathione (GSNO). The GSNO decomposition - •NO release was evaluated by UV-VIS spectroscopy and Griess assay. The H2S donor Na2S was used. O2 slightly increased, but was not necessary for the H2S-induced GSNO decom...

journal_title：General physiology and biophysics

authors： Grman M,Misak A,Jacob C,Tomaskova Z,Bertova A,Burkholz T,Docolomansky P,Habala L,Ondrias K

更新日期：2013-09-01 00:00:00

abstract：:A possible mechanism is put forward to explain the sliding of thin filaments during muscle contraction. In our model, repulsion due to electrostatic forces is the mechanism which triggers crossbridges to cause the thin filaments to slide. The mechanism proposed could operate regardless of whether the myosin heads rota...

journal_title：General physiology and biophysics

authors： Muñiz J,Marin JL,Yeomans L,Acuña H,Del Castillo LF,Cruz SA,Trujillo X,Huerta M

更新日期：1996-12-01 00:00:00

abstract：:The ionic composition of intracellular space is rigorously maintained in the expense of high-energy expenditure. It has been recently postulated that the cytoplasmic ionic composition is optimized so the energy cost of the fluctuations of calcium ion concentration is minimized. Specifically, thermodynamic arguments ha...

journal_title：General physiology and biophysics

authors： Głogocka D,Przybyło M,Langner M

更新日期：2017-04-01 00:00:00

abstract：:A number of computational methods for the description of the ligand-receptor interaction that were developed in the past decade are reviewed in this paper. The central two sections introduce the methods that are already established as useful tools for the qualitative and quantitative description of ligand-receptor com...

journal_title：General physiology and biophysics

authors： Hornák V,Dvorský R,Sturdík E

更新日期：1999-09-01 00:00:00

abstract：:Arachidonic, linolenic and linoleic acids decreased the binding of the m-cholinergic antagonist [3H] QNB and did not affect the ratio of high to low affinity binding sites to the agonist carbamoylcholine in rat brain synaptic membranes. In the presence of arachidonic acid, SH-reagent N-ethylmaleimide acquired the abil...

journal_title：General physiology and biophysics

authors： Okun IM,Merezhinskaya NV,Rakovich AA,Volkovets TM,Aksentsev SL,Konev SV

更新日期：1986-06-01 00:00:00

abstract：:Depression is a brain disorder characterized by severe emotional, cognitive, neuroendocrine and somatic dysfunction. Although the latest generation of antidepressant drugs has improved clinical efficacy and safety, the onset of their clinical effect is significantly delayed after treatment commencement, and a large nu...

journal_title：General physiology and biophysics

authors： Pavlovicova M,Lacinova L,Dremencov E

更新日期：2015-10-01 00:00:00

abstract：:The capacity of five synthetic analogs of [8-arginine] vasopressin (AVP) to stimulate frog skin sodium transport (natriferic activity) was characterized electrophysiologically using the method of short-circuit current, and compared to that of synthetic AVP. The analogs used were [8-arginine] vasopressins modified in p...

journal_title：General physiology and biophysics

authors： Bakos P,Ponec J,Alexandrová M,Lichardus B,Lammek B,Rekowski P,Kupryszewski G

更新日期：1990-12-01 00:00:00

abstract：:The postnatal development of high-affinity 3H-muscimol binding to GABAA receptors was studied in the lateral geniculate nucleus, superior colliculus, frontal and visual cortex of the rat brain. In the lateral geniculate nucleus 3H-muscimol binding rises from day 10 through day 37 reaching the highest value during the ...

journal_title：General physiology and biophysics

authors： Schliebs R,Rothe T

更新日期：1988-06-01 00:00:00

abstract：:Cochlear spiral ganglion neurons provide the only pathway for transmitting sound evoked activity from the hair cells to the central auditory system. Serotonin plays a role in the response properties of central auditory neurons. However, knowledge about the role of serotonin in the peripheral auditory nervous system re...

journal_title：General physiology and biophysics

authors： Yu C,Liu J,Chen Y,Tang Y

更新日期：2013-03-01 00:00:00

abstract：:The polyamines spermine and spermidine and the diamine putrescine inhibit lipid peroxidation in phospholipid liposome suspensions and rat liver homogenates. Using the chemiluminescence technique the antioxidant activity of polyamines was found to be due to reactions with the free radical intermediates of lipid peroxid...

journal_title：General physiology and biophysics

authors： Pavlovic DD,Uzunova P,Galabova T,Peneva V,Sokolova Z,Bjelakovic G,Ribarov S

更新日期：1992-04-01 00:00:00

abstract：:PC12 cells differentiated under the influence of the neuronal growth factor (NGF) serve as a model of both sympathetic neurons and chromaffin cells. NGF-induced differentiation critically depends on elevated intracellular calcium concentration. Main pathway for Ca²⁺ entry in excitable cells is represented by voltage-d...

journal_title：General physiology and biophysics

authors： Lichvárová L,Lacinová Ľ

更新日期：2015-04-01 00:00:00

abstract：:Recent research has supported a potential role of immune pathology in the etiopathogenesis of schizophrenic. In the CNS various viruses were identified in the brains of schizophrenic patients. Pro-inflammatory cytokines were found to be associated with the stage of disease. Microglial cells were reported to be activat...

journal_title：General physiology and biophysics

authors： Rothermundt M,Ahn JN,Jörgens S

更新日期：2009-01-01 00:00:00

abstract：:This study examines the effects of a 2.1-GHz WCDMA-modulated microwave (MW) radiation on apoptotic activity and mitochondrial membrane potential (ΔΨm) in MCF-7 cells. The cells were exposed to the MW at a specific absorption rate (SAR) of 0.528 W/kg for 4 or 24 h. The antiproliferative effect of MW exposure was determ...

journal_title：General physiology and biophysics

authors： Esmekaya MA,Canseven AG,Kayhan H,Tuysuz MZ,Sirav B,Seyhan N

更新日期：2017-04-01 00:00:00

abstract：:Photon emissions were measured at ambient temperature (21°C) in complete darkness once per min from cultures of 10(6) cells during the 12 h following removal from 37°C. The energy of emission was about 10(-20) J/s/cell. Of 8 different cell lines, B16-BL6 (mouse melanoma cells) demonstrated the most conspicuous emissio...

journal_title：General physiology and biophysics

authors： Dotta BT,Buckner CA,Cameron D,Lafrenie RF,Persinger MA

更新日期：2011-09-01 00:00:00

abstract：:The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed p...

journal_title：General physiology and biophysics

authors： Vazan R,Pancza D,Béder I,Styk J

更新日期：2005-09-01 00:00:00

abstract：:Although high-intensity electric fields (HEF) application is currently the only effective therapy available to terminate ventricular fibrillation, it may cause injury to cardiac cells. In this study we determined the relation between HEF pulse length and cardiomyocyte lethal injury. We obtained lethality curves by sur...

journal_title：General physiology and biophysics

authors： Prado LN,Goulart JT,Zoccoler M,Oliveira PX

更新日期：2016-04-01 00:00:00

abstract：:The voltage dependent ionic currents in cultured embryonic skeletal myocytes at stages of development ranging from 1 to 6 day were studied using the whole-cell patch clamp technique. Sodium (INa) and calcium (ICa) inward and potassium (IK) outward currents were observed at all stages. INa did not differ from that desc...

journal_title：General physiology and biophysics

authors： Lukyanenko VI,Katina IE,Nasledov GA,Lonsky AV

更新日期：1993-06-01 00:00:00

abstract：:The plasma membrane H(+)-ATPase of Neurospora has been reconstituted into planar lipid bilayer membranes by means of the vesicle-fusion technique described by Finkelstein and his collaborators (Zimmerberg et al., 1980; Cohen et al., 1980, 1984; Akabas et al., 1984). Enzyme was first transferred from isolated plasma me...

journal_title：General physiology and biophysics

authors： Ziegler W,Slayman CL,Cartwright CP

更新日期：1993-10-01 00:00:00