Abstract:
:Nucleosome sliding and nucleosome digestion are two main ways for regulating gene transcription. We constructed three characteristic parameters (CP) based on the information of CG0, CG1 and CG2 motifs, and used these parameters to analyze the sliding trend of -1 and +1 nucleosomes around TSS of genes with NFR in yeast. The CP distribution was used to describe the features of nucleosome sequences, and the slope of fit line of CP distribution curve was used to represent the potential energy of nucleosome sequences. Results show that nucleosome sliding trend could be reflected by CG0 and CG2 CP distributions, and CG0 CP distribution has a good correlation with nucleosome sliding trend. In addition, the sliding trend of nucleosomes is different in various expression level genes. For high expression gene, sliding trend of -1 nucleosome is weaker and that of +1 nucleosome is stronger.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Meng H,Li H,Yang Z,Si Ydoi
10.4149/gpb_2020002subject
Has Abstractpub_date
2020-05-01 00:00:00pages
269-276issue
3eissn
0231-5882issn
1338-4325journal_volume
39pub_type
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