Integrated in silico-in vitro characterization, identification and disruption of the intermolecular interaction between SH3 domain-containing protein kinases and human pituitary tumor-transforming gene 1.

abstract：:Cochlear spiral ganglion neurons provide the only pathway for transmitting sound evoked activity from the hair cells to the central auditory system. Serotonin plays a role in the response properties of central auditory neurons. However, knowledge about the role of serotonin in the peripheral auditory nervous system re...

journal_title：General physiology and biophysics

authors： Yu C,Liu J,Chen Y,Tang Y

更新日期：2013-03-01 00:00:00

abstract：:Inhibition of angiogenesis involves blocking of tyrosine kinases (TK) implicated in signalling of vascular endothelial growth factor receptors (VEFGR). The inhibition of TK results in a disruption of Ras/Raf/MEK/ERK1/2 and PI3K/Akt signalling pathways. We evaluated recently developed TK inhibitor 22SYM and compared it...

journal_title：General physiology and biophysics

authors： Moravčík R,Stebelová K,Boháč A,Zeman M

更新日期：2016-10-01 00:00:00

abstract：:In the present study, we evaluated the antioxidant potential of Artemisia campestris essential oil (ACEO) and the possible protective effects against deltamethrin induced hepatic toxic effects. The ACEO showed radical scavenging activity with IC50 = 47.66 ± 2.51 µg/ml, ferric reducing antioxidant power (FRAP) potentia...

journal_title：General physiology and biophysics

authors： Saoudi M,Ncir M,Ben Ali M,Grati M,Jamoussi K,Allouche N,El Feki A

更新日期：2017-07-01 00:00:00

abstract：:Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...

journal_title：General physiology and biophysics

authors： Parsa H,Faghihi M,Kardar GA,Imani A

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to investigate the ability of the chloroacetanilide herbicide acetochlor to interact with the endocrine system. The modulation of the binding of [3H]estradiol-17beta to protamine sulphate-precipitated uterine nuclear and cytoplasmic estrogen receptors was analysed for this purpose. Two...

journal_title：General physiology and biophysics

authors： Rollerová E,Gáspárová Z,Wsólová L,Urbancíková M

更新日期：2000-03-01 00:00:00

abstract：:Sodium nitroprusside (SNP) is a nitric oxide (•NO) donor in vitro and in vivo. In this paper the time variation of the intracellular water proton nuclear magnetic resonance (NMR) effective relaxation time T'(2a) in SNP-treated human erythrocyte suspensions, containing 10 mM membrane impermeable paramagnetic MnCl2, has...

journal_title：General physiology and biophysics

authors： Lahajnar G,Sobotič B,Sepe A,Jazbinšek V,Pečar S

更新日期：2010-12-01 00:00:00

abstract：:2-3-dimercapto-1-propane sulfonic acid, D-penicillamine and meso-dimercapto succinic acid, drugs widely applied as antidota against metal poisoning, and cysteine and glutathione were studied with respect to their ability to generate and to scavenge superoxide anion radical. Superoxide production and scavenging were te...

journal_title：General physiology and biophysics

authors： Benov LC,Ribarov SR,Monovich OH

更新日期：1992-04-01 00:00:00

abstract：:The hormone leptin, by binding to hypothalamic receptors, suppresses food intake and decreases body adiposity. Leptin receptors are also widely expressed in extra-hypothalamic areas such as hippocampus, amygdala and cerebellum, where leptin modulates synaptic transmission. Here we show that a defective leptin receptor...

journal_title：General physiology and biophysics

authors： Forero-Vivas ME,Hernández-Cruz A

更新日期：2014-01-01 00:00:00

abstract：:Many herbicides employed in agriculture and also some antibiotics bind to a specific site of the reaction centre protein (RC) blocking the photosynthetic electron transport. Crystal structures showed that all these compounds bind at the secondary ubiquinone (QB) site albeit to slightly different places. Different herb...

journal_title：General physiology and biophysics

authors： Husu I,Magyar M,Szabó T,Fiser B,Gómez-Bengoa E,Nagy L

更新日期：2015-04-01 00:00:00

abstract：:CCAAT/enhancer binding proteins (C/EBP) alpha, -beta and -delta play an important role in mediating I interleukin-6 (IL-6) dependent expression of acute-phase protein (APP) genes in liver during acute-phase (AP) response. Based on the presence of type IL-6 responsive element (IL-6 RE) in the rat haptoglobin (Hp) gene ...

journal_title：General physiology and biophysics

authors： Milosavljević T,Lazić T,Uskoković A,Petrović M,Grigorov I

更新日期：2003-06-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal L cells upon nutrients ingestion, and is currently used for treating diabetes mellitus. It plays an important role in receptor modulation and cross talk with insulin at the coronary endothelium (CE) and cardiomyocytes (CM) in diabetic type...

journal_title：General physiology and biophysics

authors： Barakat GM,Nuwayri-Salti N,Kadi LN,Bitar KM,Al-Jaroudi WA,Bikhazi AB

更新日期：2011-03-01 00:00:00

abstract：:The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...

journal_title：General physiology and biophysics

authors： Yaman MO,Guner I,Uzun H,Sahin G,Yelmen N

更新日期：2014-01-01 00:00:00

abstract：:Diabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was ...

journal_title：General physiology and biophysics

authors： Donmez BO,Ozturk N,Sarikanat M,Oguz N,Sari R,Ozdemir S

更新日期：2014-01-01 00:00:00

abstract：:The passive mechanical properties of whole muscle in active and nonactive states are compared. The experimental results are presented as stress-strain curves, which are analyzed in the framework of the current theoretical background [viz. the freely-jointed chain model (FJCM) and the worm-like chain model (WLCM)] in a...

journal_title：General physiology and biophysics

authors： Muñiz J,Marín JL,Huerta M,Del Rio J,Larios A,Trujillo X

更新日期：1999-06-01 00:00:00

abstract：:The role of C-type natriuretic peptide (CNP) in the gastrointestinal tract is still unclear. This study was designed to investigate the effect of CNP on barium current (I(Ba)) through the L-type calcium channel in gastric antral myocytes of guinea pigs. The whole-cell patch clamp technique was performed in gastric ant...

journal_title：General physiology and biophysics

authors： Sun JB,Huang X,Xu HY,Li XL,Gao L,Kim YC,Xu WX

更新日期：2006-12-01 00:00:00

abstract：:The fibroblast growth factor receptors (FGFRs) and Ras/mitogen activated protein (RAS/MAP) signalling cascades are the main molecular pathways involved in breast carcinogenesis. This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphism...

journal_title：General physiology and biophysics

authors： Dankova Z,Zubor P,Grendar M,Kapinova A,Zelinova K,Jagelkova M,Gondova A,Dokus K,Kalman M,Lasabova Z,Danko J

更新日期：2017-12-01 00:00:00

abstract：:The hyperpolarisation of the membrane potential in Characeae above that of the diffusion potential is explained by the operation of the electrogenic proton pump. We studied the interaction of calcium with the functioning of the pump. The membrane potential was measured using the standard microelectrode technique. An i...

journal_title：General physiology and biophysics

authors： Vuletić M,Vucinić Z,Radenović C

更新日期：1985-04-01 00:00:00

abstract：:Although high-intensity electric fields (HEF) application is currently the only effective therapy available to terminate ventricular fibrillation, it may cause injury to cardiac cells. In this study we determined the relation between HEF pulse length and cardiomyocyte lethal injury. We obtained lethality curves by sur...

journal_title：General physiology and biophysics

authors： Prado LN,Goulart JT,Zoccoler M,Oliveira PX

更新日期：2016-04-01 00:00:00

abstract：:A model for the dynamics of quasi-1D lipid structures in biological membranes is proposed. The model takes into account interactions between the lipid heads and hydro-carbon chains, the description of their relaxation dynamics being based on the phenomenological Ginzburg-Landau approach. It is shown that in lateral li...

journal_title：General physiology and biophysics

authors： Kadantsev VN,Tverdislov VA,Yakovenko LV,Kadantsev VV

更新日期：1997-12-01 00:00:00

abstract：:The purpose of this study was to assess the possible protective effects of Artemisia campestris against fenthion-induced nephrotoxicity in adult rats and their progeny. Fenthion was administered orally at a dose of 551 ppm, which represented ¼ of LD50, for 21 consecutive days to pregnant and lactating rats. Oxidative ...

journal_title：General physiology and biophysics

authors： Sefi M,Troudi A,Hamida FB,Soudani N,Boudawara T,Zeghal N

更新日期：2013-12-01 00:00:00

abstract：:The aim of the study was to examine the effects of epidermal growth factor (EGF) on ram sperm traits following hypothermic storage. Fresh ram ejaculates were diluted in Triladyl extender, pooled and divided into groups according to EGF doses added (0, 100, 200 or 400 ng/ml). Following 72-96 h storage at 4ºC, the sperm...

journal_title：General physiology and biophysics

authors： Makarevich AV,Spalekova E,Olexikova L,Lukac N,Kubovicova E,Hegedusova Z

更新日期：2011-01-01 00:00:00

abstract：:A possible mechanism is put forward to explain the sliding of thin filaments during muscle contraction. In our model, repulsion due to electrostatic forces is the mechanism which triggers crossbridges to cause the thin filaments to slide. The mechanism proposed could operate regardless of whether the myosin heads rota...

journal_title：General physiology and biophysics

authors： Muñiz J,Marin JL,Yeomans L,Acuña H,Del Castillo LF,Cruz SA,Trujillo X,Huerta M

更新日期：1996-12-01 00:00:00

abstract：:In P-gp-positive cell variants obtained from L1210 cells either by selection with vincristine (L1210/R) or by transfection with the human gene encoding P-gp (L1210/T), we have previously described cross-resistance to tunicamycin (TNM), a protein N-glycosylation inhibitor. Here we studied whether this cross-resistance ...

journal_title：General physiology and biophysics

authors： Pavlikova L,Seres M,Imrichova D,Hano M,Rusnak A,Zamorova M,Katrlik J,Breier A,Sulova Z

更新日期：2016-10-01 00:00:00

abstract：:Effects of six thiol reagents with different physico-chemical properties were tested on the Na+-dependent 45Ca2+ transport into the rat brain microsomal membrane vesicles. The mercurials p-chlormercuribenzoate and Mersalyl effectively inhibited 45Ca2+ uptake with IC50 values in the order of 10(-4) mol X l-1 in the med...

journal_title：General physiology and biophysics

authors： Orlický J,Ruscák M,Juhász O,Zachar J

更新日期：1987-04-01 00:00:00

abstract：:In this study, we investigated the role of AMP-activated protein kinase (AMPK) and the importance of reactive oxygen species (ROS) in apoptosis induction associated with cell cycle arrest induced by sulforaphane in AGS human gastric cancer cells. Our results demonstrated that sulforaphane inhibited proliferation of AG...

journal_title：General physiology and biophysics

authors： Choi YH

更新日期：2018-03-01 00:00:00

abstract：:Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of...

journal_title：General physiology and biophysics

authors： Matsumoto T,Tanaka M,Nakanish R,Takuwa M,Hirabayashi T,Ono K,Ikeji T,Maeshige N,Sakai Y,Akisue T,Kondo H,Ishihara A,Fujino H

更新日期：2019-05-01 00:00:00

abstract：:Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into e...

journal_title：General physiology and biophysics

authors： Altinoz E,Ozmen T,Oner Z,Elbe H,Erdemli ME,Bag HG

更新日期：2016-01-01 00:00:00

abstract：:It is currently believed that the protein folding rate is related to the protein structures and its amino acid sequence. However, few studies have been done on the problem that whether the protein folding rate is influenced by its corresponding mRNA sequence. In this paper, we analyzed the possible relationship betwee...

journal_title：General physiology and biophysics

authors： Li RF,Li H

更新日期：2011-06-01 00:00:00

abstract：:125I-labelled o-iodobenzoate (OIB) was prepared by means of an isotopic exchange reaction; its distribution and excretion were determined and its pharmacokinetic parameters in rats were calculated. The calculated value of the half-life of OIB elimination was 38.7 +/- 0.7 min, the distribution volume was 278.2 +/- 53.5...

journal_title：General physiology and biophysics

authors： Láznícek M,Kvĕtina J,Srámek B,Kronrád L,Hradílek P

更新日期：1983-08-01 00:00:00

abstract：:This study investigated the noradrenergic contribution during the cutaneous vasoconstrictor response to local cooling in the leg and forearm. On each limb, one site was perfused with Yoh/Prop to block the postsynaptic adrenoceptors and another with Lactated Ringer's (control) using microdialysis. Blood flow was measur...

journal_title：General physiology and biophysics

authors： Al-Horani RA,Mohammad M

更新日期：2018-01-01 00:00:00