Abstract：
:Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of CO2 therapy on muscle oxidative capacity impaired by streptozotocin (STZ)-induced hyperglycemia. Eight-week-old male Wistar rats were randomly divided into 4 groups: control, CO2 treatment, STZ-induced hyperglycemia, and STZ-induced hyperglycemia treated with CO2. STZ-induced hyperglycemia resulted in a decrease of muscle oxidative capacity and decreased PGC-1α and cytochrome c oxidase subunit 4 (COX-4) expression levels; while, application of transcutaneous CO2 attenuated this effect, and enhanced the expression levels of endothelial nitric oxide synthesis (eNOS). These results indicate that transcutaneous CO2 improves impaired muscle oxidative capacity via enhancement of eNOS and PGC-1α-related signaling in the skeletal muscle of rats with hyperglycemia.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Matsumoto T,Tanaka M,Nakanish R,Takuwa M,Hirabayashi T,Ono K,Ikeji T,Maeshige N,Sakai Y,Akisue T,Kondo H,Ishihara A,Fujino Hdoi
10.4149/gpb_2018048subject
Has Abstractpub_date
2019-05-01 00:00:00pages
237-244issue
3eissn
0231-5882issn
1338-4325journal_volume
38pub_type
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