The effects of acute intermittent hypoxia on cardiovascular parameters in normotensive and chronic hypobaric hypoxia-induced hypertensive rabbits.

Abstract:

:The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13 albino rabbits that divided into CHH and control groups. To develop hypertension, the rabbits were placed in a hypobaric chamber (390 mmHg; 22 hours/day, 30 days). Afterwards, AIH protocol was applied (8% FIO2 (Fraction of Inspired Oxygen) 1 min + 5 min normoxia, 20 cycles, 2 hours) to rabbits anesthetized with urethane and alpha-chloralose. Mean arterial pressure (MAP), heart rate (HR) and hematocrit values have been determined. Also asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), endothelin-1 and norepinephrine values have been analyzed in blood. We developed a model of hypertension in rabbits via exposure to severe CHH and we believe that ADMA is an important parameter in the development and permanence of CHH-induced hypertension. The main finding of this sudy was the depressor effect of AIH on blood pressure and heart rate in CHH- induced hypertension model. Finally, we believe that AIH protocol may be applicable for prevention and treatment of hypertension if properly developed.

journal_name

Gen Physiol Biophys

authors

Yaman MO,Guner I,Uzun H,Sahin G,Yelmen N

doi

10.4149/gpb_2013070

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

243-50

issue

2

eissn

0231-5882

issn

1338-4325

journal_volume

33

pub_type

杂志文章
  • Thrombin-stimulated effects on megakaryocytopoiesis and pulmonary-platelet interactions.

    abstract::The effects of thrombin stimulation on megakaryocytopoiesis and pulmonary-platelet interactions were investigated before and after administration of the compound to 15 mongrel dogs. Each dog served as its own control. Thrombin was given to encourage the traffic of megakaryocytes into the lung and to study the thrombin...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Warheit DB,Salley SO,Barnhart MI

    更新日期:1989-12-01 00:00:00

  • Early detection of myocardial viability by hyperbaric oxygenation in patients with acute myocardial infarction treated with thrombolysis.

    abstract::Hyperbaric oxygen treatment (HBO) could transiently reverse hypoxia during acute myocardial infarction (AMI). In order to evaluate whether early HBO can identify viable segments after AMI, improvement of wall motion score index (WMSI) after HBO was compared to dobutamine stress echocardiography (DSE). Thirty-one patie...

    journal_title:General physiology and biophysics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Dekleva M,Ostojic M,Neskovic A,Mazic S,Vlahovic A,Suzic Lazic J,Dekleva N

    更新日期:2009-01-01 00:00:00

  • Effect of crocin on oxidative stress in recovery from single bout of swimming exercise in rats.

    abstract::Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into e...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2015018

    authors: Altinoz E,Ozmen T,Oner Z,Elbe H,Erdemli ME,Bag HG

    更新日期:2016-01-01 00:00:00

  • Protective effects of Artemisia campestris upon fenthion-induced nephrotoxicity in adult rats and their progeny.

    abstract::The purpose of this study was to assess the possible protective effects of Artemisia campestris against fenthion-induced nephrotoxicity in adult rats and their progeny. Fenthion was administered orally at a dose of 551 ppm, which represented ¼ of LD50, for 21 consecutive days to pregnant and lactating rats. Oxidative ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2013047

    authors: Sefi M,Troudi A,Hamida FB,Soudani N,Boudawara T,Zeghal N

    更新日期:2013-12-01 00:00:00

  • Electrogenic proton pump in Nitella and the effect of calcium.

    abstract::The hyperpolarisation of the membrane potential in Characeae above that of the diffusion potential is explained by the operation of the electrogenic proton pump. We studied the interaction of calcium with the functioning of the pump. The membrane potential was measured using the standard microelectrode technique. An i...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Vuletić M,Vucinić Z,Radenović C

    更新日期:1985-04-01 00:00:00

  • A circular dichroism study of the stability of guanine quadruplexes of thrombin DNA aptamers at presence of K+ and Na+ ions.

    abstract::The effect of K+ and Na+ on the properties of DNA aptamers that selective binds to fibrinogen (FIBRI) and heparin (HEPA) exosites of human alpha-thrombin was studied by circular dichroism (CD). The complexes of FIBRI-K+ were slightly more stable than HEPA-K+. However, lower stability was observed for HEPA-K+ at presen...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Poniková S,Antalík M,Hianik T

    更新日期:2008-12-01 00:00:00

  • Cooperative dynamics of quasi-1D lipid structures and lateral transport in biological membranes.

    abstract::A model for the dynamics of quasi-1D lipid structures in biological membranes is proposed. The model takes into account interactions between the lipid heads and hydro-carbon chains, the description of their relaxation dynamics being based on the phenomenological Ginzburg-Landau approach. It is shown that in lateral li...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Kadantsev VN,Tverdislov VA,Yakovenko LV,Kadantsev VV

    更新日期:1997-12-01 00:00:00

  • The influence of protein coding sequences on protein folding rates of all-β proteins.

    abstract::It is currently believed that the protein folding rate is related to the protein structures and its amino acid sequence. However, few studies have been done on the problem that whether the protein folding rate is influenced by its corresponding mRNA sequence. In this paper, we analyzed the possible relationship betwee...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2011_02_154

    authors: Li RF,Li H

    更新日期:2011-06-01 00:00:00

  • Molecular crowding has no effect on the dilution thermodynamics of the biologically relevant cation mixtures.

    abstract::The ionic composition of intracellular space is rigorously maintained in the expense of high-energy expenditure. It has been recently postulated that the cytoplasmic ionic composition is optimized so the energy cost of the fluctuations of calcium ion concentration is minimized. Specifically, thermodynamic arguments ha...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2016029

    authors: Głogocka D,Przybyło M,Langner M

    更新日期:2017-04-01 00:00:00

  • Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats.

    abstract::This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabeti...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2012_039

    authors: Soufi FG,Vardyani M,Sheervalilou R,Mohammadi M,Somi MH

    更新日期:2012-12-01 00:00:00

  • The role of the apoptosis and the genes regulating apoptosis in the early differentiation of human embryo.

    abstract::Apoptosis (programmed cell death) is an important process participating in the formation of organs and tissues during embryogenesis. Our aim of the work is studying the role of the apoptosis during the human embryonic differentiation. We tend to give acquired findings into the correlation with expression of proteins B...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Lichnovský V,Procházková J,Erdösová B,Nepozitková D,Kolár Z

    更新日期:1999-12-01 00:00:00

  • Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats.

    abstract::Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar ra...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2014033

    authors: Miloradović Z,Mihailović-Stanojević N,Jovović Đ,Ivanov M,Vajić UJ,Karanović D,Grujić Milanović J

    更新日期:2015-01-01 00:00:00

  • Malate dehydrogenases--structure and function.

    abstract::Malate dehydrogenases (MDH, L-malate:NAD oxidoreductase, EC 1.1.1.37), catalyze the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondria...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章,评审

    doi:

    authors: Minárik P,Tomásková N,Kollárová M,Antalík M

    更新日期:2002-09-01 00:00:00

  • Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells.

    abstract::PC12 cells differentiated under the influence of the neuronal growth factor (NGF) serve as a model of both sympathetic neurons and chromaffin cells. NGF-induced differentiation critically depends on elevated intracellular calcium concentration. Main pathway for Ca²⁺ entry in excitable cells is represented by voltage-d...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2014045

    authors: Lichvárová L,Lacinová Ľ

    更新日期:2015-04-01 00:00:00

  • Developmental changes in uncoupling protein 1 and F1-ATPase subunit levels in the golden hamster brown adipose tissue mitochondria as determined by electron microscopy in situ immunocytochemistry.

    abstract::The postnatal developmental changes in mitochondrial uncoupling protein 1 (UCP 1) and F1-ATP synthase (ATPase) subunit levels in the interscapular brown adipose tissue (BAT) were studied in golden Syrian hamsters (Mesocricetus auratus) using electron microscopy in situ immunocytochemistry. The relatively low initial d...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Bednár J,Soukup T

    更新日期:2003-12-01 00:00:00

  • Suppression of natriferic activity of the vasopressin molecule by modifications in positions 1, 2 and 4.

    abstract::The capacity of five synthetic analogs of [8-arginine] vasopressin (AVP) to stimulate frog skin sodium transport (natriferic activity) was characterized electrophysiologically using the method of short-circuit current, and compared to that of synthetic AVP. The analogs used were [8-arginine] vasopressins modified in p...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Bakos P,Ponec J,Alexandrová M,Lichardus B,Lammek B,Rekowski P,Kupryszewski G

    更新日期:1990-12-01 00:00:00

  • Nonreceptor interactions in the pharmacology of blood platelets.

    abstract::On the basis of values corresponding to concentrations exhibiting 50% inhibition of platelet aggregation induced with different stimuli and 50% inhibition of arachidonic acid liberation and thromboxane generation, we compared the antiplatelet effect of two cationic amphiphilic drugs--chloroquine and dithiaden. Compare...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Nosál R,Jancinová V

    更新日期:1999-10-01 00:00:00

  • Lidocaine alters the input resistance and evokes neural activity in crayfish sensory neurons.

    abstract::Lidocaine, a use-dependent Na(+) channel blocker, paradoxically evokes neural activation in the slowly adapting stretch receptor organ of crayfish at 5-10 mmol/l concentration. For elucidating the underlying mechanisms of this paradoxical effect, a series of conventional electrophysiological experiments were performed...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Keceli MB,Purali N

    更新日期:2007-03-01 00:00:00

  • Study of activated oxygen production by some thiols using chemiluminescence.

    abstract::2-3-dimercapto-1-propane sulfonic acid, D-penicillamine and meso-dimercapto succinic acid, drugs widely applied as antidota against metal poisoning, and cysteine and glutathione were studied with respect to their ability to generate and to scavenge superoxide anion radical. Superoxide production and scavenging were te...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Benov LC,Ribarov SR,Monovich OH

    更新日期:1992-04-01 00:00:00

  • Effect of vitamin E-deficiency on the activity of some lysosomal and non-lysosomal proteases in rabbit muscles.

    abstract::The activity of different cathepsins and neutral proteinases was measured in normal and vitamin E-deficient rabbit muscles using specific substrates. Among the changes of enzyme activities in dystrophy caused by vitamin E-deficiency the increase in the activity of cathepsin B is the most striking. The activity of cath...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Katona G,Székessy-Hermann V,Guba F,Sohár I

    更新日期:1991-10-01 00:00:00

  • Tetraphenylphosphonium-selective electrode as a tool for evaluating mitochondrial permeability transition pore function in isolated rat hepatocytes.

    abstract::The changes in mitochondrial membrane potential (Deltapsi(m)) were used as an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that in situ mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncou...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Lábajová A,Kofránek J,Kriváková P,Cervinková Z,Drahota Z

    更新日期:2006-09-01 00:00:00

  • Voltage-dependent calcium channels.

    abstract::Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels. We have cloned and characterized mem...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章,评审

    doi:

    authors: Lacinová L

    更新日期:2005-06-01 00:00:00

  • Phospholipase A2 and cobra venom cytotoxin Vc5 interactions and membrane structure.

    abstract::The hydrolytic activity and interaction of acidic and neutral phospholipase A2 (PLA2) with large unilamellar liposomes treated with cobra venom cytotoxin Vc5 (CT Vc5) were studied to more fully understand the modulating effects of cationic membrane-active peptides on PLA2. Studies were done by fluorescence displacemen...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Gasanov SE,Gasanov NE,Rael ED

    更新日期:1995-04-01 00:00:00

  • Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis.

    abstract::Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章,评审

    doi:10.4149/gpb_2013067

    authors: Krizova L,Kollar B,Jezova D,Turcani P

    更新日期:2013-12-01 00:00:00

  • High-conductance chloride channels in BC3H1 myoblasts.

    abstract::The existence of a high-conductance voltage sensitive chloride channel in BC3H1 myoblasts is documented. The conductance of the channel in symmetrical 150 mmol/l sodium chloride is around 400 pS. The probability of the channel being in the open state decreases with increasing of the imposed voltage from holding potent...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Hurnák O,Zachar J

    更新日期:1993-04-01 00:00:00

  • Graphical analysis of circular dichroic spectra distinguishes between two-state and gradual alterations in DNA conformation.

    abstract::A simple graphical method is proposed to distinguish between two-state and gradual alterations in DNA conformation from circular dichroic spectra. The method is advantageous particularly to identify two-state conformational isomerizations which exhibit low degree of cooperativity. The usefulness of the method is illus...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Kypr J,Vorlícková M

    更新日期:1986-08-01 00:00:00

  • Redistribution of intracellular Ca2+ in mitogen-stimulated human peripheral blood lymphocytes.

    abstract::The fluorescent probe chlortetracycline (CTC) was used to investigate redistribution of intracellular Ca2+ in concanavalin A (Con A)-stimulated human peripheral blood lymphocytes. The addition of the mitogen to CTC-equilibrated lymphocytes induced (within 10 to 15 minutes) a Con A-concentration dependent decrease in C...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Gukovskaya AS,Zinchenko VP,Ryabichenko VV,Astashkin EI

    更新日期:1983-10-01 00:00:00

  • Inhibitory effects of pentacaine and some related local anaesthetics on rat hepatic adenylate cyclase.

    abstract::In the present study effects of a new local anaesthetics, pentacaine (trans-2-pyrolidinocyclohexylester of 3-pentyloxyphenylcarbamic acid), and of some chemically related compounds on rat hepatic adenylate cyclase activity were studied under various experimental conditions. As compared with tetracaine, the local anaes...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Hynie S,Wenke M,Klenerová V

    更新日期:1985-10-01 00:00:00

  • Cross-reacting material 197 (CRM197) affects actin cytoskeleton of endothelial cells.

    abstract::CRM197, cross-reacting material 197, is a mutant of diphtheria toxin (DTx). CRM197 is used in pharmacology as a carrier protein. It has been recently shown that CRM197 causes breakdown in actin filaments. In order to show intracellular localization of CRM197 and visualize cell structure via actin cytoskeleton, endothe...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2017006

    authors: Özerman Edis B,Varol B,Hacıosmanoğlu E,Ünlü A,Bektaş M

    更新日期:2017-10-01 00:00:00

  • Blockade of sodium and potassium channels in the node of Ranvier by ajmaline and N-propyl ajmaline.

    abstract::The inhibition of sodium and potassium currents in frog myelinated fibres by ajmaline (AM) and its quaternary derivative, N-propyl ajmaline (NPA), depends on voltage-clamp pulses and the state of channel gating mechanisms. The permanently charged NPA and protonated AM interact only (or mainly) with open channels, whil...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Khodorov BI,Zaborovskaya LD

    更新日期:1983-08-01 00:00:00