Abstract：
:The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed protective effect of melatonin on reperfusion-induced arrhythmias--arrhythmia score was significantly lower as well as the total time of arrhythmias duration was significantly shorter in melatonin group than in controls. On the other hand, post-ischemic recovering of contractility was significantly reduced in melatonin group.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Vazan R,Pancza D,Béder I,Styk Jsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
355-9issue
3eissn
0231-5882issn
1338-4325journal_volume
24pub_type
杂志文章abstract：:A model of activation of muscle contraction has been proposed. It is based on calcium diffusion and binding to specific regulatory sites in a sarcomere. Calcium ions activate interactions of contractile proteins and thus the generation of force. The model quantifies the relation between calcium released from intracell...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Apoptosis (programmed cell death) is an important process participating in the formation of organs and tissues during embryogenesis. Our aim of the work is studying the role of the apoptosis during the human embryonic differentiation. We tend to give acquired findings into the correlation with expression of proteins B...
journal_title：General physiology and biophysics
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更新日期：1999-12-01 00:00:00
abstract：:Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017049
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2015018
更新日期：2016-01-01 00:00:00
abstract：:A simple graphical method is proposed to distinguish between two-state and gradual alterations in DNA conformation from circular dichroic spectra. The method is advantageous particularly to identify two-state conformational isomerizations which exhibit low degree of cooperativity. The usefulness of the method is illus...
journal_title：General physiology and biophysics
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更新日期：1986-08-01 00:00:00
abstract：:Inhibition of angiogenesis involves blocking of tyrosine kinases (TK) implicated in signalling of vascular endothelial growth factor receptors (VEFGR). The inhibition of TK results in a disruption of Ras/Raf/MEK/ERK1/2 and PI3K/Akt signalling pathways. We evaluated recently developed TK inhibitor 22SYM and compared it...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2015055
更新日期：2016-10-01 00:00:00
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journal_title：General physiology and biophysics
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2011_02_154
更新日期：2011-06-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：1991-12-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：2000-09-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：2010-03-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：10.4149/gpb_2013067
更新日期：2013-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2011_04_379
更新日期：2011-12-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2013077
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journal_title：General physiology and biophysics
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更新日期：2018-09-01 00:00:00
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doi：10.4149/gpb_2011_SI1_36
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journal_title：General physiology and biophysics
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doi：10.4149/gpb_2018030
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journal_title：General physiology and biophysics
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doi：
更新日期：2006-06-01 00:00:00
abstract：:Lidocaine, a use-dependent Na(+) channel blocker, paradoxically evokes neural activation in the slowly adapting stretch receptor organ of crayfish at 5-10 mmol/l concentration. For elucidating the underlying mechanisms of this paradoxical effect, a series of conventional electrophysiological experiments were performed...
journal_title：General physiology and biophysics
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doi：
更新日期：2007-03-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2007-06-01 00:00:00
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journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2012_039
更新日期：2012-12-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：2002-12-01 00:00:00
abstract：:Thiamine deficiency (TD) results in lactate acidosis, which is associated with neurodegeneration. The aim of this study was to investigate this alteration in primary rat brain endothelia. Spectrophotometric analysis of culture media revealed that only a higher concentration of pyrithiamine, which accelerates the intra...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:The purpose of this study was to assess the possible protective effects of Artemisia campestris against fenthion-induced nephrotoxicity in adult rats and their progeny. Fenthion was administered orally at a dose of 551 ppm, which represented ¼ of LD50, for 21 consecutive days to pregnant and lactating rats. Oxidative ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2013047
更新日期：2013-12-01 00:00:00
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journal_title：General physiology and biophysics
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doi：
更新日期：2004-09-01 00:00:00
abstract：:Depression is a brain disorder characterized by severe emotional, cognitive, neuroendocrine and somatic dysfunction. Although the latest generation of antidepressant drugs has improved clinical efficacy and safety, the onset of their clinical effect is significantly delayed after treatment commencement, and a large nu...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：10.4149/gpb_2015013
更新日期：2015-10-01 00:00:00
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journal_title：General physiology and biophysics
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doi：10.4149/gpb_2017033
更新日期：2017-12-01 00:00:00
abstract：:Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels. We have cloned and characterized mem...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
