Abstract：
:A model of activation of muscle contraction has been proposed. It is based on calcium diffusion and binding to specific regulatory sites in a sarcomere. Calcium ions activate interactions of contractile proteins and thus the generation of force. The model quantifies the relation between calcium released from intracellular stores and the elicited force.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Poledna Jsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
81-90issue
2eissn
0231-5882issn
1338-4325journal_volume
8pub_type
杂志文章abstract：:The role of viscosity in coupling between chemical reaction (complex formation) and diffusion in membranes has been investigated. The Fick law was replaced by the momentum balance equation with the viscous term. The irreversible thermodynamics admits coupling of the chemical reaction rate with the gradient of velocity...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed p...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:The paper deals with mathematical modelling of the transients obtained by fitting of delayed fluorescence (DF) induction trace. The transients are in certain, doubtless connection with electrochemical gradient (ECG) formed across thylakoid membranes upon illumination. The fitting of the C and D transients by using con...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Depression is a brain disorder characterized by severe emotional, cognitive, neuroendocrine and somatic dysfunction. Although the latest generation of antidepressant drugs has improved clinical efficacy and safety, the onset of their clinical effect is significantly delayed after treatment commencement, and a large nu...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：10.4149/gpb_2015013
更新日期：2015-10-01 00:00:00
abstract：:Low-conductance chloride channel from skeletal muscle SR vesicles of the crayfish Astacus fluviatilis was incorporated into planar lipid bilayers and its basic characteristics were investigated. The channel has a relatively low unitary conductance of 26 pS in symmetrical 160 mmol/l choline-chloride. The dependence of ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant a...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2012_019
更新日期：2012-06-01 00:00:00
abstract：:The membrane lipid and fatty acid compositions of red blood cells from a paramyotonia patient were investigated. Cholesterol and total phospholipid contents in paramyotonia were not different from control. Only the sphingomyelin content was lower, and thus the molar ratio of phosphatidylcholine/sphingomyelin was highe...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Myosin was isolated from pig atrial and ventricular myocardium during postnatal development and Ca2+-ATPase was determined and myosin light chains were analysed by electrophoresis in sodium dodecylsulfate polyacrylamide gel. During ontogenesis ATPase activity of ventricular myosin remains virtually unchanged, whereas ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:A new theory termed "tunnel-acid-group-potential" (TAGPT), explaining the effect of pHo and pH(i) on ion conductance through different membrane channels, is presented. It is suggested that shifts in pHo and pH(i) lead to changes in values of negative charges generated by acid groups of side chains of some polar (Glu-,...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：1996-10-01 00:00:00
abstract：:Kinase-targeted therapy is a new and promising approach to disease treatment. However, some kinase inhibitors have been observed to cause an off-target adverse risk for skeletal system by influencing the growth of osteoblasts. It is known that the proliferation and differentiation of osteoblasts are essentially regula...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2018030
更新日期：2019-01-01 00:00:00
abstract：:The effects of ryanodine on negative force staircase and potentiated rested-state contraction (RC) in rat myocardium were compared to the action of Ca release stimulator (caffeine) and inhibitors (local anesthetics). Only low ryanodine concentrations (0.1-0.5 mumol/l) were found to reverse anomalous mechanical pattern...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:In the present study, we evaluated the antioxidant potential of Artemisia campestris essential oil (ACEO) and the possible protective effects against deltamethrin induced hepatic toxic effects. The ACEO showed radical scavenging activity with IC50 = 47.66 ± 2.51 µg/ml, ferric reducing antioxidant power (FRAP) potentia...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2016057
更新日期：2017-07-01 00:00:00
abstract：:Fusion of neuraminidase or trypsin pretreated human erythrocytes and untreated cells was performed. The obtained doublets had a permanent dipole moment which disappeared as a function of time. Since the dipole moment disappearance is due to protein interdiffusion the lateral diffusion constant may be determined. This ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:Liposomes and proteoliposomes obtained from rat brain were used; structural changes induced by Vc5 cytotoxin (CT) from Central Asia cobra venom have been studied by the EPR method using spin probes (5-, 10-, or 12-doxylstearic acid). The addition of CT to liposome samples, containing spin probes resulted in the appear...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:The effect of membrane composition on ethanol partitioning into lipid bilayers was assessed by headspace gas chromatography. A series of model membranes with different compositions have been investigated. Membranes were exposed to a physiological ethanol concentration of 20 mmol/l. The concentration of membranes was 2...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2009_02_140
更新日期：2009-06-01 00:00:00
abstract：:Currents through DPI 201-106 modified single cardiac sodium channels in guinea pig ventricular cells were measured using the patch clamp technique in the cell-free configuration to control the sodium concentrations on both sides of the patch membrane. Current-voltage relationships of the single channels were obtained ...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The capacity of five synthetic analogs of [8-arginine] vasopressin (AVP) to stimulate frog skin sodium transport (natriferic activity) was characterized electrophysiologically using the method of short-circuit current, and compared to that of synthetic AVP. The analogs used were [8-arginine] vasopressins modified in p...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:The existence of a high-conductance voltage sensitive chloride channel in BC3H1 myoblasts is documented. The conductance of the channel in symmetrical 150 mmol/l sodium chloride is around 400 pS. The probability of the channel being in the open state decreases with increasing of the imposed voltage from holding potent...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Recent research has supported a potential role of immune pathology in the etiopathogenesis of schizophrenic. In the CNS various viruses were identified in the brains of schizophrenic patients. Pro-inflammatory cytokines were found to be associated with the stage of disease. Microglial cells were reported to be activat...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2013070
更新日期：2014-01-01 00:00:00
abstract：:The voltage dependent ionic currents in cultured embryonic skeletal myocytes at stages of development ranging from 1 to 6 day were studied using the whole-cell patch clamp technique. Sodium (INa) and calcium (ICa) inward and potassium (IK) outward currents were observed at all stages. INa did not differ from that desc...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels. We have cloned and characterized mem...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
abstract：:The aim of the study was to compare the effect of hemophane and polysulfone membranes on the phagocyte-derived production of reactive oxygen species (ROS) as well as on neutrophil CD11b and CD62L expression in patients undergoing regular hemodialysis. The effects of hemodialysis membranes were also studied in in vitro...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into e...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2015018
更新日期：2016-01-01 00:00:00
abstract：:Malate dehydrogenases (MDH, L-malate:NAD oxidoreductase, EC 1.1.1.37), catalyze the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondria...
journal_title：General physiology and biophysics
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:Somatostatin analogues are currently used to treat various disorders such as hypersecretion and different neuroendocrine tumors. In this study we examined the effects on the adrenal cortex of somatostatin (SRIH-14) and octreotide administered subcutaneously twice daily for 5 days to adult male rats. Control rats recei...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Lignin, the structural polymer of the plant cell walls, is produced by free radical polymerization of phenolic alcohols, catalyzed by different peroxidases. The mechanism and the structural organization of lignin in the cell have not been completely understood. In this study we applied fractal analysis to images of li...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2017049
更新日期：2018-05-01 00:00:00
abstract：:The interactions between haematoporphyrin (HP) and bilayer lipid membranes (BLM) were studied. A weak effect of HP on BLM conductivity was observed at HP concentrations ranging between 10(-6) and 3 x 10(-5) mol/l. Modulus of elasticity in the direction normal to the membrane plane (E perpendicular) and dynamic viscosi...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Although high-intensity electric fields (HEF) application is currently the only effective therapy available to terminate ventricular fibrillation, it may cause injury to cardiac cells. In this study we determined the relation between HEF pulse length and cardiomyocyte lethal injury. We obtained lethality curves by sur...
journal_title：General physiology and biophysics
pub_type： 杂志文章
doi：10.4149/gpb_2015047
更新日期：2016-04-01 00:00:00
