Increased expression of cellular retinol-binding protein 1 in laryngeal squamous cell carcinoma.

abstract：:Some ellipticine derivative salts, including 9-chloro-2-methylellipticinium (CME), have been found to have a marked selectivity against all eight brain tumor cell lines of the U.S. National Cancer Institute's disease-oriented in vitro screen. We initiated in vivo antitumor studies to explore the feasibility for furthe...

journal_title：Journal of cancer research and clinical oncology

authors： Arguello F,Alexander MA,Greene JF Jr,Stinson SF,Jorden JL,Smith EM,Kalavar NT,Alvord WG,Klabansky RL,Sausville EA

更新日期：1998-01-01 00:00:00

abstract：:Stereological point-counting methods were used to determine the volumetric alterations in collagen from the lamina propria immediately beneath the epithelial-connective tissue junction in hamster check-pouch mucosa treated with the chemical carcinogen DMBA. In addition, a non-neoplastic inflammatory control was evalua...

journal_title：Journal of cancer research and clinical oncology

authors： Tarpey SG,White FH

更新日期：1984-01-01 00:00:00

abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the effectiveness and safety of ultrasound guided percutaneous radiofrequency ablation (RFA) of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma. METHODS:54 metastatic LNs confirmed by percutaneous biopsy in 33 patients with previous total thyroidectomy...

journal_title：Journal of cancer research and clinical oncology

authors： Guang Y,Luo Y,Zhang Y,Zhang M,Li N,Zhang Y,Tang J

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

journal_title：Journal of cancer research and clinical oncology

authors： Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Proton therapy could minimize the risk of side effects and, therefore, reduce the possible detrimental effect on health-related quality of life (HRQOL) of re-irradiation. The aim of this study was to determine the effect of re-irradiation with active scanning proton therapy on recurrent glioblastoma (GBM) in te...

journal_title：Journal of cancer research and clinical oncology

authors： Scartoni D,Amelio D,Palumbo P,Giacomelli I,Amichetti M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Clinical trials have reported conflicting results as to whether taxane-based doublet improves outcome over single-agent taxane in patients with advanced breast cancer. METHODS:We performed a meta-analysis comparing primary and secondary end points of taxane-based doublet with single-agent taxane chemotherapy i...

journal_title：Journal of cancer research and clinical oncology

authors： Xu HB,Xu Q,Li L

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:The primary cause of local recurrence and therapeutic failure in the treatment of malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it is known that malignant gliomas infiltrate diffusely into regions of normal brain, it is frequently very difficult to unequivocally ident...

journal_title：Journal of cancer research and clinical oncology

authors： Jung S,Kim HW,Lee JH,Kang SS,Rhu HH,Jeong YI,Yang SY,Chung HY,Bae CS,Choi C,Shin BA,Kim KK,Ahn KY

更新日期：2002-09-01 00:00:00

abstract：:Cases of cancer notified to the Danish Cancer Registry during the period 1970 to 1984 in the age groups 16 to 66 years have been linked to information on employment kept on file in the nationwide Supplementary Pension Fund since 1964. Industrial hygienists classified industrial groups as defined by the Pension Fund wi...

journal_title：Journal of cancer research and clinical oncology

authors： Olsen JH,Møller H,Jensen OM

更新日期：1988-01-01 00:00:00

abstract：:Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkyl...

journal_title：Journal of cancer research and clinical oncology

authors： Wiessler M

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:How could we transfer knowledge about healing plants from other cultures? We analyzed the results of literature search in two exemplary fields-oral mucositis and polyneuropathy. MATERIALS AND METHODS:In both systematic searches of existing literature, we found 57 studies investigating 68 plants from differen...

journal_title：Journal of cancer research and clinical oncology

authors： Büntzel J,Micke O,Büntzel J

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14-16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to further evaluate the prognostic role of age in a homogenously treated patient co...

journal_title：Journal of cancer research and clinical oncology

authors： Berger K,Turowski B,Felsberg J,Malzkorn B,Reifenberger G,Steiger HJ,Budach W,Haussmann J,Knipps J,Rapp M,Hänggi D,Sabel M,Mijderwijk HJ,Kamp MA

更新日期：2021-01-01 00:00:00

abstract：:Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen. N-propyl-N'-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 micrograms/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Ra...

journal_title：Journal of cancer research and clinical oncology

authors： Matsukura N,Itabashi M,Kawachi T,Hirota T,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:Metastasis remains one of the major challenges before hepatocellular carcinoma (HCC) is finally conquered. This paper summarized a decade's studies on HCC metastasis at the Liver Cancer Institute of Fudan University. We have established a stepwise metastatic human HCC model system, which included a metastatic HCC mode...

journal_title：Journal of cancer research and clinical oncology

authors： Tang ZY,Ye SL,Liu YK,Qin LX,Sun HC,Ye QH,Wang L,Zhou J,Qiu SJ,Li Y,Ji XN,Liu H,Xia JL,Wu ZQ,Fan J,Ma ZC,Zhou XD,Lin ZY,Liu KD

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:A high proportion of cancer patients use complementary and alternative medicine (CAM). In oncology, risks of CAM are side effects and interactions. OBJECTIVE:Our aim was to conduct a survey on professionals in palliative care regarding attitudes toward CAM. DESIGN AND SUBJECTS:An internet-based survey with...

journal_title：Journal of cancer research and clinical oncology

authors： Conrad AC,Muenstedt K,Micke O,Prott FJ,Muecke R,Huebner J

更新日期：2014-07-01 00:00:00

abstract：:Trends in mortality from cancer of the gall-bladder and bile ducts over the period 1965-1989 were analysed for 25 European countries on the basis of official death certifications from the World Health Organization databank. A high-mortality area--i.e. with overall death certification rates, world standard, around or o...

journal_title：Journal of cancer research and clinical oncology

authors： Zatonskí W,La Vecchia C,Levi F,Negri E,Lucchini F

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The high comorbidity in patients with head and neck cancer (HNC) is mainly caused by the high incidence of tobacco and alcohol abuse and has direct impact on overall survival. We investigated whether HNC and its comorbidity also influence routine laboratory values and whether these values have influence on over...

journal_title：Journal of cancer research and clinical oncology

authors： Peter F,Wittekindt C,Finkensieper M,Kiehntopf M,Guntinas-Lichius O

更新日期：2013-01-01 00:00:00

abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

journal_title：Journal of cancer research and clinical oncology

authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level. TOPICS AND METHODS: Biochemical and biological studies of green tea cate...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Imai K,Nakachi K,Shimizu M,Moriwaki H,Suganuma M

更新日期：2012-08-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：:The XP cell strain XP29MA, its malignant counterpart XP29MAmal and a normal human fibroblast strain were tested for colony-forming ability after treatment with HECNU in the presence of m6G, m6Gua, and he7G. In XP29MAmal, inhibition of post-HECNU colony-forming ability was 35% when 0.25 mM of either m6G or m6Gua were p...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Edler L,Müller N,Eisenbrand G

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To evaluate the pattern of recurrence of breast cancer according to its biological subtype in a large cohort of patients treated with therapy representative of current practice. PATIENTS AND METHODS:Patients treated between 2000 and 2016 with known biological subtype were eligible. Data were prospectively coll...

journal_title：Journal of cancer research and clinical oncology

authors： Ignatov A,Eggemann H,Burger E,Ignatov T

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

journal_title：Journal of cancer research and clinical oncology

authors： Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Proteins involved in the aberrant regulation of signaling pathways and their downstream effectors are promising targets for cancer therapy. Survivin is an anti-apoptotic and cell cycle-promoting protein, which is consistently overexpressed in cancer cells. In normal cells, its expression is tightly controlle...

journal_title：Journal of cancer research and clinical oncology

authors： Weiss A,Brill B,Borghouts C,Delis N,Mack L,Groner B

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Cholangiocarcinoma is defined as a chronic liver disease with altered estrogen metabolism and could result in estrogen retention. Estrogenic response was known as a promoting factor in progression of some cancer. In this study, we determined the significant increase of estrogen level in cholangiocarcinoma patie...

journal_title：Journal of cancer research and clinical oncology

authors： Hunsawong T,Singsuksawat E,In-chon N,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-in S,Thuwajit P

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vit...

journal_title：Journal of cancer research and clinical oncology

authors： Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Melanoma antigen gene A3 (MAGE-A3) is aberrantly expressed in a number of cancer types. Because of its high specificity, MAGE-A3 has shown to be a promising candidate for cancer immunotherapy. Dendritic cells (DCs) have emerged as the natural agents for antigen delivery. DCs transduced with antigen may increase...

journal_title：Journal of cancer research and clinical oncology

authors： Lin L,Wei J,Chen Y,Huang A,Li KK,Zhang W

更新日期：2014-02-01 00:00:00