Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide.

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：:Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

journal_title：Journal of cancer research and clinical oncology

authors： Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To investigate the relationship between microvessel density, expression of vascular endothelial growth factor A (VEGF-A) and micrometastases in peripheral blood of patients with breast cancer. METHOD:Microvessel density (MVD) and expression of VEGF-A were detected by immunohistochemistry S-P. Nested RT-PCR was...

journal_title：Journal of cancer research and clinical oncology

authors： Xie XD,Qu SX,Liu ZZ,Zhang F,Zheng ZD

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:The primary cause of local recurrence and therapeutic failure in the treatment of malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it is known that malignant gliomas infiltrate diffusely into regions of normal brain, it is frequently very difficult to unequivocally ident...

journal_title：Journal of cancer research and clinical oncology

authors： Jung S,Kim HW,Lee JH,Kang SS,Rhu HH,Jeong YI,Yang SY,Chung HY,Bae CS,Choi C,Shin BA,Kim KK,Ahn KY

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：:The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 patients with HCC who became alpha-fetoprotein-(AFP)-negative after resection between 1975 and 1991. By March 199...

journal_title：Journal of cancer research and clinical oncology

authors： Zhou XD,Tang ZY,Yu YQ,Yang BH,Lu JZ,Lin ZY,Ma ZC,Zhang BH

更新日期：1994-01-01 00:00:00

abstract：:Three human cell lines derived from Ewing's sarcoma (RM-82, VH-64, and WE-68) were investigated to establish the influence of recombinant human interferon gamma (rhIFN gamma) and tumour necrosis factor alpha (rhTNF alpha) on cell proliferation and survival and to characterize IFN gamma and TNF alpha receptor expressio...

journal_title：Journal of cancer research and clinical oncology

authors： van Valen F,Winkelmann W,Burdach S,Göbel U,Jürgens H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：:Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and i...

journal_title：Journal of cancer research and clinical oncology

authors： Wiltschke C,Kindas-Muegge I,Steininger A,Reiner A,Reiner G,Preis PN

更新日期：1994-01-01 00:00:00

abstract：:Multicellular tumor spheroids (MCTS) grown from the bladder cancer cell line RT112 and from the prostate cancer cell line PCA were exposed to 200 or 800 electromagnetically generated focused ultrasound shock waves. RT112 cells showed a distinct but transient decrease in proliferation whereas the effect of PCA cells wa...

journal_title：Journal of cancer research and clinical oncology

authors： Nicolai H,Steinbach P,Knuechel-Clarke R,Grimm D,Roessler W,Wieland WF,Hofstaedter F

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To explore lymph node-related risk factors and investigate the benefit of different adjuvant therapy strategies in hypopharyngeal squamous-cell carcinoma (HPSCC) patients with nodal metastasis (N +). METHODS:We conducted a retrospective review covering 266 HPSCC patients with nodal metastasis. Kaplan-Meier cur...

journal_title：Journal of cancer research and clinical oncology

authors： Lin H,Wang T,Heng Y,Zhu X,Zhou L,Zhang M,Shi Y,Cao P,Tao L

更新日期：2020-07-29 00:00:00

abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

journal_title：Journal of cancer research and clinical oncology

authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Constructed from a theoretical framework, the coordinated undermining of survival paths in glioblastoma (GBM) is a combination of nine drugs approved for non-oncological indications (CUSP9; aprepitant, auranofin, captopril, celecoxib, disulfiram, itraconazole, minocycline, quetiapine, and sertraline) combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Skaga E,Skaga IØ,Grieg Z,Sandberg CJ,Langmoen IA,Vik-Mo EO

更新日期：2019-06-01 00:00:00

abstract：:The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

journal_title：Journal of cancer research and clinical oncology

authors： Schuller HM,Orloff M,Reznik GK

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Evidence shows that exon 19 deletions (19del) and exon 21 Leu858Arg point mutation (L858R) of EGFR are different in response to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in advanced lung cancers. However, the impact of the two mutational types in the early stage lung adenocarcinoma is unknown. MET...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang Y,Ma Y,Li Y,Shen X,Yu Y,Pan Y,Zhang Y,Yu S,Zheng D,Zhao Y,Hu H,Sun Y,Zhang Y,Xiang J,Chen H

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To calculate the accuracy of the Tokuhashi score (TS) in recent patients with vertebral metastasis (VM), candidates or not to surgical treatment, and thus to assess the external validity of TS. METHODS:Retrospective analysis of prospectively collected data from 90 patients (55 men, 35 women) with VM between 20...

journal_title：Journal of cancer research and clinical oncology

authors： Hernandez-Fernandez A,Vélez R,Lersundi-Artamendi A,Pellisé F

更新日期：2012-09-01 00:00:00

abstract：:In this summary, J. Konietzko (Mainz) stressed the exceptional position of occupational cancer, which is due to the long latent period between exposure to specific carcinogens and cancer manifestation. Obviously, this long latent period of years to decades poses problems in the search for the etiology of occupational ...

journal_title：Journal of cancer research and clinical oncology

authors： Berger MR

更新日期：1994-01-01 00:00:00

abstract：:In order to evaluate a possible significance of the expression of proliferating cell nuclear antigen (PCNA) as clinically useful prognostic parameter, we retrospectively investigated a series of 40 glioblastomas by means of immunohistochemistry and compared the results to patient survival. All glioblastomas included i...

journal_title：Journal of cancer research and clinical oncology

authors： Figge C,Reifenberger G,Vogeley KT,Messing M,Roosen N,Wechsler W

更新日期：1992-01-01 00:00:00

abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

journal_title：Journal of cancer research and clinical oncology

authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:De novo malignancy is a worrying complication after kidney transplantation; the type of which may vary due to factors such as the prevalence of viral infection and race. Kaposi sarcoma used to be the most common malignancy among our patients constituting more than one-third of cancers. Nevertheless, we notic...

journal_title：Journal of cancer research and clinical oncology

authors： Donia AF,Fouda MA,Ghoneim ME,Refaie AF,Ali-El-Dein B

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

更新日期：2020-01-01 00:00:00

abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

journal_title：Journal of cancer research and clinical oncology

authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Explore molecular monitoring patterns of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitors therapy in China and identify variables associated with monitoring patterns. METHODS:Non-interventional, cross-sectional study using questionnaires distributed to persons with CML and answered an...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Gale RP

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To explore the appropriate method of mediastinal lymph node dissection for selected clinical stage IA (cIA) non-small cell lung cancer (NSCLC). METHODS:From 1998 through 2002, the curative-intent surgery was performed to 105 patients with cIA NSCLC who had been postoperatively identified as pathologic-stage T1...

journal_title：Journal of cancer research and clinical oncology

authors： Ma K,Chang D,He B,Gong M,Tian F,Hu X,Ji Z,Wang T

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is the second most common leading cause of cancer-related death. Cancer stem cell (CSC) with the mark of CD44 played an important role in GC. rMETase was wildly exploited as chemotherapeutic option for GC. Polymers synthetic nanoparticle drug delivery systems have been commonly used for c...

journal_title：Journal of cancer research and clinical oncology

authors： Li YF,Zhang HT,Xin L

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

journal_title：Journal of cancer research and clinical oncology

authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

更新日期：2020-12-01 00:00:00

abstract：:Protein extracted from conventional formalin-fixed and paraffin-embedded tissue sections of human gliomas was examined for immunoblot analysis using antibody against the placental form of glutathione S-transferase (GST-pi). Four benign astrocytomas, five anaplastic astrocytomas and four glioblastomas were used in this...

journal_title：Journal of cancer research and clinical oncology

authors： Hara A,Sakai N,Yamada H,Yoshimi N,Tanaka T,Mori H

更新日期：1993-01-01 00:00:00