Aromatase in breast cancer tissue--localization and relationship with reproductive status of patients.

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In ad...

journal_title：Journal of cancer research and clinical oncology

authors： Seidel HJ,Stolz W

更新日期：1984-01-01 00:00:00

abstract：:Methods have been developed in an in vitro system (1) of assessing the number of disseminated tumor cells in peripheral blood and (2) of enriching tumor cells from peripheral blood samples for further characterization. Cells from three human carcinoma lines (E 14, ChaGo, and LEDWiDr) were mixed with leukocytes from no...

journal_title：Journal of cancer research and clinical oncology

authors： Schwartz R,Walk A,Toomes H,Schirrmacher V

更新日期：1985-01-01 00:00:00

abstract：:Disseminated histiocytosis X with cutaneous and lymph node involvement was diagnosed in a 25-year-old women. The diagnosis was established on the basis of a positive cell-surface staining with OKT 6 and typical signs on electron microscopy. Both the specific skin rash and lymph node swelling completely disappeared dur...

journal_title：Journal of cancer research and clinical oncology

authors： Scherbaum WA,Seif FJ

更新日期：1995-01-01 00:00:00

abstract：:The clinical course--and hence the prognosis--of patients suffering from malignant tumors are essentially determined by the capability of tumor cells to metastasize. During the past decade knowledge about genetic aberrations, as well as molecular and cell biological mechanisms which are involved in the regulation of t...

journal_title：Journal of cancer research and clinical oncology

authors： Engers R,Gabbert HE

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:The N-myc downstream regulated gene 1 (NDRG1)/Cap43 is overexpressed in multiple cancer types, including lung cancer. In this study, we investigated the expression of NDRG1/Cap43 in lung cancer tissues and in serum from 90 lung cancer patients and 60 healthy controls. MATERIALS AND METHODS:Ninety patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Wang D,Tian X,Jiang Y

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in protein isoprenylation. Post-translational modification and activation of...

journal_title：Journal of cancer research and clinical oncology

authors： Garnett DJ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To determine the incidence of hepatocellular carcinoma in cirrhosis and to examine the influence of age and sex, and the contribution of etiological factors. METHODS:967 patients with liver cirrhosis and free of hepatocellular carcinoma were enrolled in this longitudinal, retrospective and observational study....

journal_title：Journal of cancer research and clinical oncology

authors： del Olmo JA,Serra MA,Rodríguez F,Escudero A,Gilabert S,Rodrigo JM

更新日期：1998-01-01 00:00:00

abstract：:This article summarizes the various current uses of cytokines, and bone marrow and peripheral blood stem cell transplantation for cancer treatment. Interferons, interleukin-2 and hematopoietic growth factors are extensively used for the treatment of hematopoietic as well as nonhematopoietic malignancies, either as the...

journal_title：Journal of cancer research and clinical oncology

authors： Takaku F

更新日期：1995-01-01 00:00:00

abstract：:Laboratory and clinical data suggest some interactions between cytotoxic agents and tamoxifen. The mechanisms of these interactions differ in estrogen-receptor-negative cell lines. The ability of tamoxifen to modify the effects of epirubicin on the cell-cycle phases of estrogen-receptor-negative Ehrlich's carcinoma as...

journal_title：Journal of cancer research and clinical oncology

authors： Aydiner A,Ridvanogullari M,Anil D,Topuz E,Nurten R,Disci R

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:beta-1,4-Galactosyltransferase (beta-1,4-GalT) I, II, and V are the enzymes responsible for the biosynthesis of N-acetyllactosamine on N-glycans by transferring UDP-galactose to the terminal N-acetylglucosamine (N-GlcNAc) residues with the formation of a beta-1,4-linkage. Neoplasms undergo various changes in th...

journal_title：Journal of cancer research and clinical oncology

authors： Xu S,Zhu X,Zhang S,Yin S,Zhou L,Chen C,Gu J

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. METHODS:IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cell...

journal_title：Journal of cancer research and clinical oncology

authors： Chen X,Chen F,Ren Y,Weng G,Xu L,Xue X,Keng PC,Lee SO,Chen Y

更新日期：2019-06-01 00:00:00

abstract：:A total of 30 inbred Wistar rats were orally administered 70 microgram/ml solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 35 weeks and then tap water for the following 20 to 30 weeks. Four of the 20 females and two of ten males developed carcinoids in the glandular stomach, but no metastasis could be found...

journal_title：Journal of cancer research and clinical oncology

authors： Tahara E,Ito H,Nakagami K,Shimamoto F

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage...

journal_title：Journal of cancer research and clinical oncology

authors： Du J,Li Y,Lv S,Wang Q,Sun C,Dong X,He M,Ulain Q,Yuan Y,Tuo X,Batchu N,Song Q,Li Q

更新日期：2016-12-01 00:00:00

abstract：:Soft-agar clonogenicity of L1210 mouse leukemia cells and of xenografts of a human melanoma and a carcinoma of the cervix was studied sectionally by the sizes of the colonies grown under hypoxic gradients and aerobic condition. Soft-agar plating efficiency was increased in cultured L1210 cells with decreasing oxygen c...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Fan S,Morgan LR

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:With the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models. METHODS:A retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate ca...

journal_title：Journal of cancer research and clinical oncology

authors： Veen KM,de Angst IB,Mokhles MM,Westgeest HM,Kuppen M,Groot CAU,Gerritsen WR,Kil PJM,Takkenberg JJM

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix. METHODS:Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using t...

journal_title：Journal of cancer research and clinical oncology

authors： Horn LC,Höhn AK,Hentschel B,Fischer U,Bilek K,Brambs CE

更新日期：2019-02-01 00:00:00

abstract：:The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greate...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukahara T,Tamura M,Yamazaki H,Kurihara H,Matsuzaki S

更新日期：1992-01-01 00:00:00

abstract：:The aim of our work was to investigate whether DNA topoisomerase II participates in the repair-specific incision of UV-irradiated genomic DNA. Therefore, the influence upon DNA incision of the topoisomerase II inhibitors (nalidixic and oxolinic acid, novobiocin and coumermycin A1) as well as the intercalating agent qu...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Popanda O,Edler L

更新日期：1991-01-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Melanoma antigen gene A3 (MAGE-A3) is aberrantly expressed in a number of cancer types. Because of its high specificity, MAGE-A3 has shown to be a promising candidate for cancer immunotherapy. Dendritic cells (DCs) have emerged as the natural agents for antigen delivery. DCs transduced with antigen may increase...

journal_title：Journal of cancer research and clinical oncology

authors： Lin L,Wei J,Chen Y,Huang A,Li KK,Zhang W

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of a novel low dose chemotherapy as a remission induction regimen for elderly de novo AML patients ineligible for intensive chemotherapy. METHOD:Fifty consecutive patients, aged 60 to 85, with untreated de novo AML were enrolled. Patients with poor PS or defined non-hematolo...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Kanemura N,Hara T,Kasahara S,Yamada T,Sawada M,Oyama M,Moriwaki H

更新日期：2007-08-01 00:00:00

abstract：:A phase II trial of etoposide (100 mg/m2) on days 4, 5, 6, doxorubicin (Adriamycin, 20 mg/m2) on days 1, 7, and cisplatin (30 mg/m2) on days 2, 8 (EAP) was carried out in order to reduce toxicity associated with a full-dose EAP regimen for advanced and/or metastatic gastric adenocarcinoma. Out of 21 evaluable patients...

journal_title：Journal of cancer research and clinical oncology

authors： Gebbia V,Valenza R,Testa A,Sciume C,Longo A,Cipolla C,Borsellino N,Leo P,Latteri M,Florena M

更新日期：1994-01-01 00:00:00

abstract：:Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascula...

journal_title：Journal of cancer research and clinical oncology

authors： Pautu V,Mellinger A,Resnier P,Lepeltier E,Martin L,Boussemart L,Letournel F,Passirani C,Clere N

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Lee HC,Kim JG,Chae YS,Sohn SK,Kang BW,Moon JH,Jeon SW,Lee MH,Lim KH,Park JY,Choi GS,Jun SH

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

journal_title：Journal of cancer research and clinical oncology

authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

journal_title：Journal of cancer research and clinical oncology

authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00

abstract：:Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelat...

journal_title：Journal of cancer research and clinical oncology

authors： Francis P,Markman M,Hakes T,Reichman B,Rubin S,Jones W,Lewis JL Jr,Curtin J,Barakat R,Phillips M

更新日期：1993-01-01 00:00:00