Induction of antigen-specific immune responses by dendritic cells transduced with a recombinant lentiviral vector encoding MAGE-A3 gene.

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-alpha and PDGFR-beta. Investigations were performed to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation and apoptosis induction were measured with and wi...

journal_title：Journal of cancer research and clinical oncology

authors： Mundhenke C,Weigel MT,Sturner KH,Roesel F,Meinhold-Heerlein I,Bauerschlag DO,Schem C,Hilpert F,Jonat W,Maass N

更新日期：2008-12-01 00:00:00

abstract：:The influence of infusion time and dose on the anticancer efficacy of 5-fluoro-2'-deoxyuridine (FdUrd) was investigated using a locoregional therapy model: Novikoff hepatoma transplanted i.m. into the thigh of Wistar rats and FdUrd infusion via a catheter implanted in the femoral artery. In experiment A the FdUrd dose...

journal_title：Journal of cancer research and clinical oncology

authors： Naser-Hijazi B,Berger MR,Schmähl D,Schlag P,Hull WE

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：:Adenocarcinomas of the lungs show a variable histology. We have subclassified such lesions into five cell types: hobnail, columnar, polygonal, mixed and goblet cell types, and investigated their relationships with K-ras mutations. Codons 12, 13 and 61 of the K-ras gene in 120 surgically resected pulmonary adenocarcino...

journal_title：Journal of cancer research and clinical oncology

authors： Tsuchiya E,Furuta R,Wada N,Nakagawa K,Ishikawa Y,Kawabuchi B,Nakamura Y,Sugano H

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:We compared laparoscopic approach with the conventional laparotomy approach for the treatment of patients with endometrial carcinoma in developing country. METHODS:Two hundred and seventy-two patients with endometrial carcinoma were enrolled in a prospective randomized trial and treated with laparoscopic or la...

journal_title：Journal of cancer research and clinical oncology

authors： Lu Q,Liu H,Liu C,Wang S,Li S,Guo S,Lu J,Zhang Z

更新日期：2013-11-01 00:00:00

abstract：:Twenty-five surgical specimens of malignant human prostate, 3 lymph nodes with metastatic prostate carcinoma, 11 normal human prostates, as well as 3 human prostate cell lines (DU-145, PC3 and LNCaP) were examined for the expression of the human matrix metalloproteinase-7 gene (MMP-7) from the human collagenase family...

journal_title：Journal of cancer research and clinical oncology

authors： Pajouh MS,Nagle RB,Breathnach R,Finch JS,Brawer MK,Bowden GT

更新日期：1991-01-01 00:00:00

abstract：:The carcinogenic effectiveness of nitrosomethyl-n-butylamine,-n-hexylamine and -n-heptylamine was compared by administration to F344 rats at various concentrations in drinking water and by gavage in oil. Nitrosomethylbutylamine induced only tumors of the upper gastrointestinal tract, and was very toxic. Nitrosomethylh...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Reuber MD,Singer GM

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. METHODS:HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic le...

journal_title：Journal of cancer research and clinical oncology

authors： Li Y,Tang Y,Ye L,Liu B,Liu K,Chen J,Xue Q

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

journal_title：Journal of cancer research and clinical oncology

authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

更新日期：2020-01-01 00:00:00

abstract：:In this study we investigated the presence of epidermal growth factor receptors (EGF-R) and the tissue levels of EGF-like factors (EGF-F) in ovarian, endometrial, cervical and breast carcinomas. EGF-R were found in 33/40 (83%) cervical, 15/26 (58%) endometrial, 64/141 (45%) ovarian, and 19/59 (33%) breast carcinomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Bauknecht T,Kohler M,Janz I,Pfleiderer A

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：:Trends in mortality from cancer of the gall-bladder and bile ducts over the period 1965-1989 were analysed for 25 European countries on the basis of official death certifications from the World Health Organization databank. A high-mortality area--i.e. with overall death certification rates, world standard, around or o...

journal_title：Journal of cancer research and clinical oncology

authors： Zatonskí W,La Vecchia C,Levi F,Negri E,Lucchini F

更新日期：1993-01-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：:We measured an estrogen-receptor-associated protein (ER-D5), estrogen and progesterone receptors (ER; PgR) in samples obtained from 28 female patients with primary breast carcinoma. A correlation of r = 0.79 was found between ER-D5 and ER values and between ER-D5 and PgR values in premenopausal woman. In postmenopausa...

journal_title：Journal of cancer research and clinical oncology

authors： Navarro MA,Guardia M,Arranz B,Bonnin MR,Rosel P

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes of action, expressi...

journal_title：Journal of cancer research and clinical oncology

authors： Bracht K,Kiefer T,Dölken G,Bednarski PJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:As previously described, SPC/myc transgenic mice developed bronchioloalveolar adenocarcinomas derived from alveolar type II (AT II) cells within 10-14 months, whereas SPC/IgEGF transgenic mice developed hyperplasias. Our purpose was to determine the potential interplay of environmental and genetic factors in lu...

journal_title：Journal of cancer research and clinical oncology

authors： Ehrhardt A,Bartels T,Klocke R,Paul D,Halter R

更新日期：2003-02-01 00:00:00

abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

journal_title：Journal of cancer research and clinical oncology

authors： Bohr VA

更新日期：1990-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperative...

journal_title：Journal of cancer research and clinical oncology

authors： Gimm O,Sutter T,Dralle H

更新日期：2001-01-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To examine the associations between modifiable health-related factors, such as smoking, low physical activity and higher body mass index (BMI), and annual health care visits and expenditures among adult cancer survivors in the United States. METHODS:Using data from the 2010-2014 Medical Expenditures Panel Su...

journal_title：Journal of cancer research and clinical oncology

authors： Kaul S,Avila JC,Jupiter D,Rodriguez AM,Kirchhoff AC,Kuo YF

更新日期：2017-12-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) exerts cytotoxic and antiproliferative effects on neoplastic cells. It has been used as a therapeutic agent for solid tumours and haematological malignancies. We report on the ex vivo determination of the effect of recombinant human rhuTNF alpha on bone marrow aspirates by a br...

journal_title：Journal of cancer research and clinical oncology

authors： Kleine HD,Wagner U,Poliwoda H,Freund M

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lympho...

journal_title：Journal of cancer research and clinical oncology

authors： Chobrutskiy BI,Zaman S,Diviney A,Mihyu MM,Blanck G

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To investigate the relationship between microvessel density, expression of vascular endothelial growth factor A (VEGF-A) and micrometastases in peripheral blood of patients with breast cancer. METHOD:Microvessel density (MVD) and expression of VEGF-A were detected by immunohistochemistry S-P. Nested RT-PCR was...

journal_title：Journal of cancer research and clinical oncology

authors： Xie XD,Qu SX,Liu ZZ,Zhang F,Zheng ZD

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The optimal interval between neoadjuvant chemoradiotherapy (CRT) and surgery has yet to be established. Additionally, it is unknown whether patients with different pathologic stages or chemoradiation responses should undergo different intervals between CRT and surgery. Therefore, the purpose of this study wa...

journal_title：Journal of cancer research and clinical oncology

authors： You KY,Huang R,Zhang LN,Ding PR,Xiao WW,Qiu B,Chang H,Zeng ZF,Pan ZZ,Gao YH

更新日期：2015-04-01 00:00:00

abstract：:The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor c...

journal_title：Journal of cancer research and clinical oncology

authors： Laursen ML

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

journal_title：Journal of cancer research and clinical oncology

authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:The feasibility of radioimmunotherapy (RAIT) combined with 5-fluorouracil (5-FU) was examined in colon cancer xenografts. The mode of interaction of the two treatments was also investigated. METHODS:Mice bearing human colon cancer were treated with a combination of 4.63 MBq (L-RAIT) or 9.25 MBq (H-RAIT) (131)I...

journal_title：Journal of cancer research and clinical oncology

authors： Kinuya S,Yokoyama K,Tega H,Hiramatsu T,Konishi S,Watanabe N,Shuke N,Aburano T,Takayama T,Michigishi T,Tonami N

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00