Novel treatment of ovarian cancer cell lines with Imatinib mesylate combined with Paclitaxel and Carboplatin leads to receptor-mediated antiproliferative effects.

abstract：OBJECTIVE:The aim of this study was to identify novel genes following genomic DNA copy number changes using a genome-wide array-based comparative genomic hybridization (array-CGH) analysis in uterine leiomyosarcoma (ULMS). METHODS:Genomic DNA copy number changes were analyzed in 15 cases of ULMS from St Mary's Hospita...

journal_title：Journal of cancer research and clinical oncology

authors： Raish M,Khurshid M,Ansari MA,Chaturvedi PK,Bae SM,Kim JH,Park EK,Park DC,Ahn WS

更新日期：2012-07-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma ( n=20; age range 16-49 years) and chondrosarcoma ( n=15; age range 18-70 y...

journal_title：Journal of cancer research and clinical oncology

authors： Açil Y,Springer I,Behrens P,Ullrich KP,Hedderich J,Bruns J

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:The aim of this study is to investigate whether GDF3 is related to the progression of human breast cancer and the effects of GDF3 on breast cancer cells. METHODS:The expression of GDF3 in 24 breast cancer specimens paired with corresponding neighboring nontumorous tissue was studied by Western blot. Breast can...

journal_title：Journal of cancer research and clinical oncology

authors： Li Q,Ling Y,Yu L

更新日期：2012-06-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：:The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greate...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukahara T,Tamura M,Yamazaki H,Kurihara H,Matsuzaki S

更新日期：1992-01-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The aim of our study was to identify factors which influence survival in patients with disseminated seminoma in the good prognostic group according to IGCCCG, as well as to evaluate the impact of treatment intensification in patients with negative prognostic factors. METHODS:We analyzed the database of the pat...

journal_title：Journal of cancer research and clinical oncology

authors： Fedyanin M,Tryakin A,Bulanov A,Vybarava A,Tjulandina A,Chekini D,Sekhina O,Figurin K,Garin A,Tjulandin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta1 (TGF-beta1) and its receptor II (TGF-betaRII) are two key components of TGF-beta signaling and play an important role in carcinogenesis. Several functional polymorphisms were identified in TGFB1 and TGFBR2 and associated with elevated serum or plasma level of TGF-beta1 and enhan...

journal_title：Journal of cancer research and clinical oncology

authors： Jin G,Deng Y,Miao R,Hu Z,Zhou Y,Tan Y,Wang J,Hua Z,Ding W,Wang L,Chen W,Shen J,Wang X,Xu Y,Shen H

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:We performed deep sequencing of target genes in head and neck squamous cell carcinoma (HNSCC) tumors to identify somatic mutations that are associated with induction chemotherapy (IC) response. METHODS:Patients who were diagnosed with HNSCC were retrospectively identified. Patients who were treated with IC wer...

journal_title：Journal of cancer research and clinical oncology

authors： Ock CY,Son B,Keam B,Lee SY,Moon J,Kwak H,Kim S,Kim TM,Jeon YK,Kwon SK,Hah JH,Lee SH,Kwon TK,Kim DW,Wu HG,Sung MW,Heo DS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Approximately 5% of patients with cutaneous squamous cell carcinoma (CSCC) may develop recurrent or metastatic disease. The management of such cases is challenging and requires multi-disciplinary care. Immunotherapy using PD-1 inhibition was approved to treat unresectable or metastatic CSCC in 2018. Given limit...

journal_title：Journal of cancer research and clinical oncology

authors： In GK,Vaidya P,Filkins A,Hermel DJ,King KG,Ragab O,Tseng WW,Swanson M,Kokot N,Lang JE,Menendez L,DeClerck B,Kim G,Hu JC,Terando A,Jadvar H,Ricker C,Miller KA,Peng DH,Wysong A

更新日期：2020-11-18 00:00:00

abstract：PURPOSE:Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and development. The purpose of this study was to examine the involvement of stat...

journal_title：Journal of cancer research and clinical oncology

authors： Xi W,Rui W,Fang L,Ke D,Ping G,Hui-Zhong Z

更新日期：2009-06-01 00:00:00

abstract：:Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymp...

journal_title：Journal of cancer research and clinical oncology

authors： Averdunk R,Bippus PH,Günther T,Merker HJ

更新日期：1982-01-01 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To investigate the clinicopathological features and survival outcomes between young and old patients with gastric cancer (GC), and further determine the role of young age in the prognosis of GC. METHODS:Patients with stage I-III gastric adenocarcinomas undergoing curative surgery were enrolled, divided into yo...

journal_title：Journal of cancer research and clinical oncology

authors： Cheng L,Chen S,Wu W,Kuo ZC,Wei Z,Meng S,Chen C,Zhang C,He Y

更新日期：2020-11-01 00:00:00

abstract：:The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor c...

journal_title：Journal of cancer research and clinical oncology

authors： Laursen ML

更新日期：1980-01-01 00:00:00

abstract：:The association of Epstein-Barr virus (EBV) with gastric medullary carcinoma with lymphoid infiltration (GMCL) was investigated. The presence of GMCL exhibited a 2/1 male-to-female ratio and a 1/2 early-to-advanced cancer ratio, predominantly located in the cardia and corpus of the stomach (90%). The presence of EBV D...

journal_title：Journal of cancer research and clinical oncology

authors： Takano Y,Kato Y,Sugano H

更新日期：1994-01-01 00:00:00

abstract：:The role of different cytogenetic changes has been extensively evaluated in patients with acute myeloid leukemia (AML), and cytogenetic analysis of AML blasts is essential to form prognostic subgroups in order to stratify for the extent of therapy. Nevertheless, 40-45% of AML patients lack such cytogenetic markers, i....

journal_title：Journal of cancer research and clinical oncology

authors： Scholl S,Fricke HJ,Sayer HG,Höffken K

更新日期：2009-04-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：:The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. In vitro in the sulphorhodamine B cell-viability assay the cytotoxicity of epidoxorubicin was increased approximately 15-fold...

journal_title：Journal of cancer research and clinical oncology

authors： Van de Vrie W,Schellens JH,Loss WJ,Kolker HJ,Verwey J,Stoter G,Durante NM,Eggermont AM

更新日期：1996-01-01 00:00:00

abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

journal_title：Journal of cancer research and clinical oncology

authors： Hemminki K,Försti A,Mustonen R,Savela K

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To study the effects of surgery and timing of radiotherapy on patient survival in grade 2 gliomas. METHODS:One hundred and eighty-nine patients with diffuse astrocytomas, oligoastrocytomas, and oligodendrogliomas, World Health Organization grade 2, treated between 1982 and 2000 were identified. The impact of t...

journal_title：Journal of cancer research and clinical oncology

authors： Ribom D,Smits A,Hartman M,Persson L,Blomquist E

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Apatinib, a third-line or later treatment for advanced gastric cancer (aGC), was shown to improve overall survival and progression-free survival (PFS) compared with placebo in the phase III trial. Given the modest benefit with high costs, we further evaluated the cost-effectiveness of apatinib for patients w...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HD,Zhou J,Wen F,Zhang PF,Zhou KX,Zheng HR,Yang Y,Li Q

更新日期：2017-02-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：:Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkyl...

journal_title：Journal of cancer research and clinical oncology

authors： Wiessler M

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Signalling through the insulin-like growth factor 1 receptor (IGF-1R) is implicated in carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. The purpose of this study was to investigate the prognostic role of IGF-1R expression in surgically resected non-small-cell lung cancer (NSCLC), and re...

journal_title：Journal of cancer research and clinical oncology

authors： Agulló-Ortuño MT,Díaz-García CV,Agudo-López A,Pérez C,Cortijo A,Paz-Ares L,López-Ríos F,Pozo F,de Castro J,Cortés-Funes H,López Martín JA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:The functional relationship between promoter hypermethylation and gene inactivation has been demonstrated for few genes only. We examined the promoter methylation status of two important tumor suppressor genes APAF-1 and DAPK-1 in bladder cancer as well as the mRNA expression pattern of these two genes for poss...

journal_title：Journal of cancer research and clinical oncology

authors： Christoph F,Hinz S,Kempkensteffen C,Weikert S,Krause H,Schostak M,Schrader M,Miller K

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00