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On the issue of early and aggressive treatment in grade 2 gliomas.

Abstract：

PURPOSE:To study the effects of surgery and timing of radiotherapy on patient survival in grade 2 gliomas. METHODS:One hundred and eighty-nine patients with diffuse astrocytomas, oligoastrocytomas, and oligodendrogliomas, World Health Organization grade 2, treated between 1982 and 2000 were identified. The impact of treatment given and clinical parameters were studied in univariate- and multivariate survival analyses. RESULTS:Median survival for the whole patient sample was 6.4 years and the 5-year survival rate was 60%. Macroscopic total resection was beneficial in the univariate analysis (P=0.03) but not when adjusting for confounders. Early subtotal resection did not prolong survival. Early radiotherapy was associated with a shorter survival time compared to delayed or no irradiation (P=0.004). However, this difference was mainly due to an unequal distribution of prognostic factors and was not significant in the multivariate analysis. The most important predictors for long survival time were young age ( P<0.001), oligodendroglioma histology ( P<0.001), and small tumour size ( P=0.02). CONCLUSIONS:Early conventional treatment with surgery and radiotherapy had no positive effect on patient survival. This opens up the possibility of trying and evaluating other first-line treatment regimens in this disease.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Ribom D,Smits A,Hartman M,Persson L,Blomquist E

doi

10.1007/s00432-003-0423-0

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

154-60

issue

3

eissn

0171-5216

issn

1432-1335

journal_volume

129

pub_type

杂志文章

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