TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population.

abstract：PURPOSE:We studied the antitumor activity of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reactions of 2-amino-5-methylphenol with bovine hemoglobin, on human B cell lymphoblastoid cell lines, P3HR-1 and Raji derived from African Burkitt's lymphoma, and the human T...

journal_title：Journal of cancer research and clinical oncology

authors： Koshibu-Koizumi J,Akazawa M,Iwamoto T,Takasaki M,Mizuno F,Kobayashi R,Abe A,Tomoda A,Hamatake M,Ishida R

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:In advanced ovarian cancers (OCs), p53 mutations are frequently observed. The objective of this study was to explore the value of the p53 mutational status, using four different techniques, in advanced OC patients as a predictive marker for responsiveness to platinum-based chemotherapy. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Bauerschlag DO,Schem C,Weigel MT,Von Kaisenberg C,Strauss A,Bauknecht T,Maass N,Meinhold-Heerlein I

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Serrated adenomas (SAs), which include a wide spectrum of lesions, can be broadly divided into two subtypes: type I, closely mimicking hyperplastic polyps (HPs), and type II, unequivocal adenomatous tumor. Our preliminary findings showed clinicopathologic differences between them. The present study was conducte...

journal_title：Journal of cancer research and clinical oncology

authors： Mitomi H,Sada M,Kobayashi K,Igarashi M,Mori A,Kanazawa H,Nishiyama Y,Ihara A,Otani Y

更新日期：2003-08-01 00:00:00

abstract：:A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MD...

journal_title：Journal of cancer research and clinical oncology

authors： Verbeek W,Wörmann B,Koch P,Aul C,Hinrichs HF,Balleisen L,Rowe JM,Bennett J,Haase D,Fonatsch C,Heinecke A,Büchner T,Hiddemann W

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. METHODS:We conducted a population study based on the Taiwan National Health Insurance da...

journal_title：Journal of cancer research and clinical oncology

authors： Chao CT,Wang CY,Lai CF,Huang TM,Chen YY,Kao TW,Chu TS,Chang CH,Wu VC,Ko WJ,Chen L,Wu KD,National Taiwan University Study Group on Acute Renal Failure.

更新日期：2014-04-01 00:00:00

abstract：:Antiproliferative effects of free retinoic acid (RA) and liposome-encapsulated RA (RAlp) were compared in a squamous carcinoma system using both monolayer cells and multicellular tumor spheroids (MTS), an in-vivo-like model with three-dimensional histological structure. Initial studies examined the effect of lipid com...

journal_title：Journal of cancer research and clinical oncology

authors： Sacks PG,Oke V,Mehta K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC s...

journal_title：Journal of cancer research and clinical oncology

authors： Rinaldetti S,Wirtz R,Worst TS,Hartmann A,Breyer J,Dyrskjot L,Erben P

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

journal_title：Journal of cancer research and clinical oncology

authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

更新日期：2020-12-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells are a group of pluripotent stem cells artificially derived from non-pluripotent cells typically by a forced expression of specific transcription factors. Generation of cancer-specific iPS cells, also called induced pluripotent cancer (iPC) cells, provides valuable experimental plat...

journal_title：Journal of cancer research and clinical oncology

authors： Sun C,Liu YK

更新日期：2011-01-01 00:00:00

abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

journal_title：Journal of cancer research and clinical oncology

authors： Schweinsberg F,Kouros M,Manncke K

更新日期：1979-10-01 00:00:00

abstract：:The primary objective of this study was to determine the response rate of patients with metastatic colorectal cancer to combined therapy with 5-fluorouracil (5-FU), leucovorin, and intravenous azidothymidine (AZT), a thymidine nucleoside analog. By itself, AZT has limited antineoplastic efficacy. However, experimental...

journal_title：Journal of cancer research and clinical oncology

authors： Clark J,Sikov W,Cummings F,Browne M,Akerley W,Wanebo H,Weitberg A,Kennedy T,Cole B,Bigley J,Beitz J,Darnowski J

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

journal_title：Journal of cancer research and clinical oncology

authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare...

journal_title：Journal of cancer research and clinical oncology

authors： Sehouli J,Tomè O,Dimitrova D,Camara O,Runnebaum IB,Tessen HW,Rautenberg B,Chekerov R,Muallem MZ,Lux MP,Trarbach T,Gitsch G

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：:The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greate...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukahara T,Tamura M,Yamazaki H,Kurihara H,Matsuzaki S

更新日期：1992-01-01 00:00:00

abstract：:The subsets and functions of lymphocytes were investigated in patients with nasopharyngeal carcinoma (NPC). The patients were divided into two groups comprising tumor-bearing patients and those in remission. There was no difference in the proportion of T cells among tumor-bearing, remission and healthy control groups....

journal_title：Journal of cancer research and clinical oncology

authors： Tsukuda M,Sawaki S,Yanoma S

更新日期：1993-01-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：:Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen. N-propyl-N'-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 micrograms/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Ra...

journal_title：Journal of cancer research and clinical oncology

authors： Matsukura N,Itabashi M,Kawachi T,Hirota T,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

journal_title：Journal of cancer research and clinical oncology

authors： Almendral AC

更新日期：1984-01-01 00:00:00

abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

journal_title：Journal of cancer research and clinical oncology

authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

更新日期：1991-01-01 00:00:00

abstract：:Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progres...

journal_title：Journal of cancer research and clinical oncology

authors： Dass CR,Ek ET,Choong PF

更新日期：2007-03-01 00:00:00

abstract：:1,1,2-Triphenylbut-1-enes substituted with 3- or 4-acetoxy (OAc) groups on one, two, or three phenyl rings were tested for their estrogen receptor affinities, their estrogenic and antiestrogenic properties in the immature mouse, and their effect on the growth of the hormone-dependent MXT mammary tumor of the mouse. Th...

journal_title：Journal of cancer research and clinical oncology

authors： Schneider MR

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS:This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we t...

journal_title：Journal of cancer research and clinical oncology

authors： Melling N,Bachmann K,Hofmann B,El Gammal AT,Reeh M,Mann O,Moebius C,Blessmann M,Izbicki JR,Grupp K

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Since 1997, several monoclonal antibodies (mAbs) targeting the same receptor or its ligand have been approved for use in oncology. However, no studies have summarized head-to-head trials of these mAbs. METHODS:Systematic search of the biomedical literature and ClinicalTrials.gov for randomized studies compa...

journal_title：Journal of cancer research and clinical oncology

authors： Luo J,Nishikawa G,Prasad V

更新日期：2019-09-01 00:00:00

abstract：:Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in ten primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carcinomas with trabecular and tubula...

journal_title：Journal of cancer research and clinical oncology

authors： Szendröi M,Lapis K

更新日期：1985-01-01 00:00:00

abstract：:Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and i...

journal_title：Journal of cancer research and clinical oncology

authors： Wiltschke C,Kindas-Muegge I,Steininger A,Reiner A,Reiner G,Preis PN

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Within hypoxic tumor regions anaerobic dissimilation of glucose is the sole source of energy generation. It yields only 5% of the ATP that is normally gained by means of oxidative glucose catabolism. The increased need for glucose may aggravate cancer cachexia. We investigated the impact of recombinant human...

journal_title：Journal of cancer research and clinical oncology

authors： van Halteren HK,Bongaerts GP,Verhagen CA,Kamm YJ,Willems JL,Grutters GJ,Koopman JP,Wagener DJ

更新日期：2004-04-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00