Sequential studies on the histopathogenesis of gastric carcinoma in rats by a weak gastric carcinogen, N-propyl-N'-nitro-N-nitrosoguanidine.

abstract：:This study compares the level of DNA-DNA interstrand crosslinking in murine bone marrow with the decrease in mean number of blood progenitor cells in mice treated with chloroethylnitrosoureas. Male C57BL6 X C3HF1 mice were treated with single IP injections of 1-(2-chloroethyl)-1-nitroso-3-(methylene-carboxamido)-urea ...

journal_title：Journal of cancer research and clinical oncology

authors： Bedford P,Berger MR,Eisenbrand G,Schmähl D

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To investigate the relationship between microvessel density, expression of vascular endothelial growth factor A (VEGF-A) and micrometastases in peripheral blood of patients with breast cancer. METHOD:Microvessel density (MVD) and expression of VEGF-A were detected by immunohistochemistry S-P. Nested RT-PCR was...

journal_title：Journal of cancer research and clinical oncology

authors： Xie XD,Qu SX,Liu ZZ,Zhang F,Zheng ZD

更新日期：2009-03-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：:The subsets and functions of lymphocytes were investigated in patients with nasopharyngeal carcinoma (NPC). The patients were divided into two groups comprising tumor-bearing patients and those in remission. There was no difference in the proportion of T cells among tumor-bearing, remission and healthy control groups....

journal_title：Journal of cancer research and clinical oncology

authors： Tsukuda M,Sawaki S,Yanoma S

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Oral cancer (OC) patients are at high risk to develop recurrent disease or secondary primary cancers with no available biomarkers to detect these events until a visible lesion is readily present and diagnosed by biopsy. Exosomes secreted by cancer cells are involved in tumor growth, invasion and metastasis. We ...

journal_title：Journal of cancer research and clinical oncology

authors： Zlotogorski-Hurvitz A,Dayan D,Chaushu G,Salo T,Vered M

更新日期：2016-01-01 00:00:00

abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

journal_title：Journal of cancer research and clinical oncology

authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To analyse hepcidin serum and urine levels during radiotherapy for prostate cancer. METHODS:In 18 patients undergoing radiotherapy for prostate cancer, blood, plasma, and urine samples were taken before and during radiotherapy. Complete blood cell count, pro-hepcidin-, ferritin-, transferrin-, IL-1beta-, IL-6-...

journal_title：Journal of cancer research and clinical oncology

authors： Christiansen H,Saile B,Hermann RM,Rave-Fränk M,Hille A,Schmidberger H,Hess CF,Ramadori G

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. METHODS:IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cell...

journal_title：Journal of cancer research and clinical oncology

authors： Chen X,Chen F,Ren Y,Weng G,Xu L,Xue X,Keng PC,Lee SO,Chen Y

更新日期：2019-06-01 00:00:00

abstract：:Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Kovatch RM,Knutsen GL

更新日期：1985-01-01 00:00:00

abstract：:Differentiation of the rat myelomonocytic leukemia cell line (c-WRT-7) was investigated, by co-culture with a rat embryonic bone marrow preadipose cell line (REC A16). Co-cultivation with REC A16, or with conditioned medium from REC A16 cultures (REC-CM), induced differentiation of c-WRT-7 cells to macrophages. A solu...

journal_title：Journal of cancer research and clinical oncology

authors： Tanaka T,Okamura S,Yasumoto S,Takeichi N,Kobayashi H,Niho Y

更新日期：1993-01-01 00:00:00

abstract：:The effects of three non-myelotoxic cancer drugs on the growth of neuroblastoma cells were investigated in vitro and in vivo: dihydroxyphenylalanine (L-dopa, a drug with selective toxicity for melanoma cells), DL-buthionine sulphoximine (BSO, a drug with radiosensitizing effects), and tamoxifen (a drug used in the tre...

journal_title：Journal of cancer research and clinical oncology

authors： Busse E,Bartsch O,Kornhuber B

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

journal_title：Journal of cancer research and clinical oncology

authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

更新日期：2020-01-01 00:00:00

abstract：:The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with ...

journal_title：Journal of cancer research and clinical oncology

authors： Kodama M,Ioki Y,Nagata C

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS:Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 wh...

journal_title：Journal of cancer research and clinical oncology

authors： Aragaki M,Hida Y,Kato T,Fujiwara-Kuroda A,Kaga K,Wakasa S

更新日期：2020-11-05 00:00:00

abstract：:Soft-agar clonogenicity of L1210 mouse leukemia cells and of xenografts of a human melanoma and a carcinoma of the cervix was studied sectionally by the sizes of the colonies grown under hypoxic gradients and aerobic condition. Soft-agar plating efficiency was increased in cultured L1210 cells with decreasing oxygen c...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Fan S,Morgan LR

更新日期：1984-01-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activate...

journal_title：Journal of cancer research and clinical oncology

authors： Grothey A,Voigt W,Schöber C,Müller T,Dempke W,Schmoll HJ

更新日期：1999-01-01 00:00:00

abstract：:Three human cell lines derived from Ewing's sarcoma (RM-82, VH-64, and WE-68) were investigated to establish the influence of recombinant human interferon gamma (rhIFN gamma) and tumour necrosis factor alpha (rhTNF alpha) on cell proliferation and survival and to characterize IFN gamma and TNF alpha receptor expressio...

journal_title：Journal of cancer research and clinical oncology

authors： van Valen F,Winkelmann W,Burdach S,Göbel U,Jürgens H

更新日期：1993-01-01 00:00:00

abstract：:A total of 30 inbred Wistar rats were orally administered 70 microgram/ml solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 35 weeks and then tap water for the following 20 to 30 weeks. Four of the 20 females and two of ten males developed carcinoids in the glandular stomach, but no metastasis could be found...

journal_title：Journal of cancer research and clinical oncology

authors： Tahara E,Ito H,Nakagami K,Shimamoto F

更新日期：1981-01-01 00:00:00

abstract：:A total of 45 cases of bone tumors and tumor-like lesions were studied in order to determine the expression of an HLA-DR antigen by the monoclonal antibody 910-D-7, and its possible correlation with histology, using the indirect immunoperoxidase method on frozen sections. The pattern of antigen expression was nearly c...

journal_title：Journal of cancer research and clinical oncology

authors： Petzsch M,Vassallo J,Roessner A,Zwadlo G,Sorg C,Vollmer E,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：:Altered and deregulated cellular oncogenes were found in many human solid tumors. Except for a few types of tumors that consistently exhibited specific altered proto-oncogenes, the majority of tumors are associated with a number of transcriptionally activated cellular oncogenes. In the heterologous group of non-small-...

journal_title：Journal of cancer research and clinical oncology

authors： Kiefer PE,Wegmann B,Bacher M,Erbil C,Heidtmann H,Havemann K

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Tobacco exposure remains the main etiologic factor for lung cancer (LC). Interactions between environment and individual genetic profile are particularly important for this disease. The aim of this study was to evaluate the contribution of CYP1A1*2A, CYP1A1*2C, CYP2D6*4, GSTP1, GSTM1, GSTT1 and NAT2 polymorp...

journal_title：Journal of cancer research and clinical oncology

authors： Mota P,Silva HC,Soares MJ,Pego A,Loureiro M,Cordeiro CR,Regateiro FJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). METHODS:A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this re...

journal_title：Journal of cancer research and clinical oncology

authors： Wang WT,Zhu HY,Wu YJ,Xia Y,Wu JZ,Wu W,Liang JH,Wang L,Fan L,Li JY,Xu W

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To determine the incidence of hepatocellular carcinoma in cirrhosis and to examine the influence of age and sex, and the contribution of etiological factors. METHODS:967 patients with liver cirrhosis and free of hepatocellular carcinoma were enrolled in this longitudinal, retrospective and observational study....

journal_title：Journal of cancer research and clinical oncology

authors： del Olmo JA,Serra MA,Rodríguez F,Escudero A,Gilabert S,Rodrigo JM

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its...

journal_title：Journal of cancer research and clinical oncology

authors： Sasahira T,Nishiguchi Y,Kurihara-Shimomura M,Nakashima C,Kuniyasu H,Kirita T

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes of action, expressi...

journal_title：Journal of cancer research and clinical oncology

authors： Bracht K,Kiefer T,Dölken G,Bednarski PJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

journal_title：Journal of cancer research and clinical oncology

authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

更新日期：2001-07-01 00:00:00

abstract：:The chemotherapeutic action of tegafur (FT) against adenocarcinoma 755 in mice was markedly potentiated by oral administration of L-cysteine and L-cystine without increasing its toxicity. In particular, the combination of FT at 200 mg/kg per day (maximum dose) and 1000 mg/kg per day of L-cystine markedly inhibited tum...

journal_title：Journal of cancer research and clinical oncology

authors： Iigo M,Hoshi A,Kitagawa H

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Apatinib, a third-line or later treatment for advanced gastric cancer (aGC), was shown to improve overall survival and progression-free survival (PFS) compared with placebo in the phase III trial. Given the modest benefit with high costs, we further evaluated the cost-effectiveness of apatinib for patients w...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HD,Zhou J,Wen F,Zhang PF,Zhou KX,Zheng HR,Yang Y,Li Q

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Tumour cells killing by cytotoxic therapies largely depends on triggering the intrinsic apoptosome-mediated caspase activation pathway but it had never been evaluated whether the expression of transcripts encoding the core components of apoptosome pathway is altered in non-small cell lung carcinoma (NSCLC). ME...

journal_title：Journal of cancer research and clinical oncology

authors： Krepela E,Procházka J,Fiala P,Zatloukal P,Selinger P

更新日期：2006-01-01 00:00:00

abstract：:Female rats aged 3 months and 15 months each received a single i.v. administration of N-nitrosomethylurea (NMU) at one of three doses: 10, 20, and 50 mg/kg. The rats exposed to NMU at the age of 3 months developed neoplasms of all sites examined, including mammary carcinomas and tumors of the kidney, ovaries and colon...

journal_title：Journal of cancer research and clinical oncology

authors： Anisimov VN

更新日期：1988-01-01 00:00:00