Dose-dependent effect of trichloropropene oxide on benzo[a]pyrene carcinogenesis.

Abstract:

:The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with B[a]P metabolism was discussed.

authors

Kodama M,Ioki Y,Nagata C

doi

10.1007/BF00413182

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

105-7

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

98

pub_type

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