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Structural requirements for inhibitors of poly(ADP-ribose) polymerase.

Abstract：

:The purpose of this study was to examine the structure/activity relationships of a series of substituted benzamides as poly(ADP-ribose) polymerase inhibitors. The experimental approach has involved the use of in vitro and in vivo assays in order to gather information either on the intrinsic activity of the benzamides or on the effect of various pharmacodynamic parameters on the activity in vivo. Although some discrepancies between the data obtained in vivo and in vitro were found in this study, results seem to indicate that most powerful inhibitors were characterized by acylation of the -NH2 function in the 3 position or by substitution in this same position with hydroxy or methoxy groups. The best inhibitors were not cytotoxic under these experimental conditions. Computed calculations of molecular electrostatic potential of these molecules were also performed and a good correlation was found between the similarity index and the experimental inhibitory activity.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Sestili P,Spadoni G,Balsamini C,Scovassi I,Cattabeni F,Duranti E,Cantoni O,Higgins D,Thomson C

doi

10.1007/BF01637083

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

615-22

issue

6

eissn

0171-5216

issn

1432-1335

journal_volume

116

pub_type

杂志文章

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